EMS 2010 Annual Meeting

Tuesday, October 26, 2010
7:00 AM–5:00 PM
	Registration	Texas Ballroom Foyer
7:00 AM–8:30 AM
	Breakfast Meetings
	Executive Board Meeting	Sundance 4
	Heritable Mutation and Disease Special Interest Group Leaders: Carole Yauk, Health Canada and Francesco Marchetti, Lawrence Berkeley National Laboratory	Sundance 3
	Risk Assessment Special Interest Group Leaders: David A. Eastmond, University of California, Riverside and Nagu Keshava, U.S. Environmental Protection Agency	Sundance 2
8:30 AM–11:30 AM
	Posters and Exhibits Last chance to view posters and exhibits!	Texas Ballroom E
8:30 AM–9:30 AM
	Plenary Lecture 3 Keap1 Eye on NRF2: Targets for Disease Prevention Chairperson: Patricia L. Opresko, University of Pittsburgh Lecturer: Thomas Kensler, University of Pittsburgh	Texas Ballroom F
9:45 AM–12:15 PM
	Symposium 10 Inflammation: From Molecules to Human Populations Chairpersons: Leona D. Samson, Massachusetts Institute of Technology	Texas Ballroom F
9:45 AM–10:10 AM	Processing and Consequences of Oxidative DNA Damage Susan S. Wallace, University of Vermont
10:10 AM–10:35 AM	Etiologic Linkage of Mitochondrial Genome Damage to Inflammation Sankar Mitra, University of Texas, Galveston
10:35 AM–11:00 AM	Role of DNA Repair in Suppressing Inflammation-Induced Disease Leona D. Samson, Massachusetts Institute of Technology
11:00 AM–11:15 AM	Break
11:15 AM–11:40 AM	The Role of 8-oxoG in Eliciting an Inflammatory Response Istvan Boldogh, University of Texas Medical Branch
11:40AM–12:05 PM	Chemopreventive Efficacy of Agents that Interact with the Antioxidant Response Element and Agents that Induce the Ah Receptor Ronald A. Lubet, National Cancer Institute, NIH
12:05 PM–12:15 PM	Discussion
9:45 AM–12:15 PM
	Symposium 11 Biomarkers of Exposure Chairperson: Matthew A. Coleman, Lawrence Livermore National Laboratory and Paul T. Henderson, University of California, Davis (Presenting author is underlined)	Texas Ballroom G
9:45 AM–10:00 AM	Models and Confounding Factors in Biomarker Development Matthew A. Coleman, Lawrence Livermore National Laboratory
10:00 AM–10:30 AM	Next Generation Biomarkers and the Exposome Joe Shuga, University of California, Berkeley
10:30 AM–11:00 AM	Phosphorylation of Smc1 Can be Used to Measure Activation of the DNA Damage Response and to Detect Human Richard Ivey. Fred Hutchinson Cancer Research Center
11:00 AM–11:15 AM	Break
11:15 AM–11:45 AM	Magneto-Nano Chips for Ultrasensitive and Multiplex Detection of Biomarkers of Tumor and Exposure Shan Wang; Stanford University
11:45 AM–12:00 NOON	TP-53 Mutational Signature of an Environmental Carcinogen Grollman AP, Moriya M, Jelakovic B, Slade N, Brdar B, Medverec Z, Wu L, Zavadil J, Hatchwell E, Wu X-R, Fernandes A, Dickman K, Chen C-H, Pu Y-S
12:00 NOON–12:15 PM	Epigenetic Markers of Hepatotoxicity: A Nevirapine Story Pereira SA, Tryndyak VP, Pogribny IP, FA Beland FA
12:15 PM–2:00 PM
	Lunch on your own
12:30 PM–2:00 PM
	WEMS Luncheon The Leaky Pipeline of Women in Science: Patching the Pipe or Rebuilding the Infrastructure? Chairpersons: Brinda Mahadevan, Abbott Laboratories and Marilyn Aardema—Marilyn Aardema Consulting LLC Primary Sponsor: Research Corporation for Science Advancement Lecturer: Carrie D. Wolinetz, Association of American Universities	Sundance 2
12:45 PM–2:00 PM
	Hollaender Commttee Meeting (Lunch on your own)	Sundance 3
2:15 PM–4:45 PM
	Symposium 12 DNA Repair, Epigenetics and Genomic Stability Chairperson: Bevin P. Engelward, Massachusetts Institute of Technology and Mitchell S. Turker, Oregon Health and Science University Organized by the Epigenetics Special Interest Group Supported in Part by: Integrated Laboratory Systems	Texas Ballroom F
2:15 PM–2:20 PM	Introduction Bevin P. Engelward, Massachusetts Institute of Technology
2:20 PM–2:45 PM	Epigenetic Changes Promote Mutations Alfonso Bellacosa, Fox Chase Cancer Center
2:45 PM–3:10 PM	Histone Methylation: The Link between Chromatin Structure and DNA Repair Brendan D. Price, Dana-Farber Cancer Institute
3:10 PM–3:35 PM	Exploring the DNA Repair-Chromatin Remodeling Interface Sandeep Burma, UT Southwestern Medical Center, Dallas
3:35 PM–4:00 PM	Short Term Changes in Gene Expression Can Lead to Long Term Epigenetic Reprogramming Mitchell S. Turker, Oregon Health and Science University
4:00 PM–4:15 PM	Discussion
2:15 PM–4:15 PM
	Platform Session 2 Heritable Mutations/Cancer Chairpersons: Jessica L. Lyon, New York University School of Medicine and Antoine M. Snijders, Lawrence Berkeley National Laboratories Organized by the Heritable Mutation and Disease Special Interest Group (Presenting author is underlined)
2:15 PM–2:30 PM	Mainstream and Sidestream Tobacco Smoke Induce Mutations in Male Germ Cells But Not Micronuclei in Erythrocytes in the Mouse Marchetti F, Polyzos A, William A, Bishop J, Yauk C
2:30 PM–2:45 PM	Prenatal and Postnatal Cigarette Smoke Exposures Increase Susceptibility to Adult Disease Lyon JL, Gordon T
2:45 PM–3:00 PM	Early and Persistent Low Dose Damage Response Pathways in the Mouse Mammary Gland Depends on Genotype, Tissue Compartment and Exposure Regimen Marchetti F, Snijders AM, Bhatnagar S, Parvin B, Han J, Lenburg M, Wyrobek AJ
3:00 PM–3:15 PM	Normal Tissue Injury Responses in Mammary Glands after Low Doses of Ionizing Radiation Snijders AM, Marchetti F, Bhatnagar S, Pendem SV, Bjornstad K, Mao JH, Blakely E, Cooper PK, Wyrobek AJ
3:15 PM–3:30 PM	Reduction in Telomerase Activity and Telomere Length - An Early Event in Carcinogenesis by PCBs? Perumal Kuppusamy S, Jacobus J, Klingelhutz AJ, Lehmler HJ, Robertson LW, Ludewig G
3:30 PM–3:45 PM	Role of von-Hippel Lindau Tumor Suppressor Gene Mutations in the Modulation of Susceptibility to Environmental Carcinogens DeSimone MC, Rathmell WK, Threadgill DW
3:45 PM–4:00 PM	Mechanisms of Chromosomal Instability in Melanoma Kaufmann W, Carson C, Zhou Y, Simpson D, Omolo B, Chu H, Ibrahim J, Shields J, Thomas NE
4:00 PM–4:15 PM	Automated Classification of Human Metaphase Chromosomes: Optimization of an Adaptive Computerized Scheme and Recognition of the Philadelphia Chromosome Mulvihill JJ, Wang X, Zheng B, Li S, Liu H
2:15 PM–4:15 PM
	Platform Session 3 Toxicology Chairpersons: Matthew J. LeBaron, The Dow Chemical Company and Lya G. Hernandez, The National Institute for Public Health and the Environment (RIVM) Organized by the Transgenic and In Vivo Mutagenesis Special Interest Group and the Risk Assessment Special Interest Group (Presenting author is underlined)	Texas Ballroom I
2:15 PM–2:30 PM	*Comparison of Carcinogenic Potency Estimates to In Vivo* Genotoxic Potencies from the Micronucleus, Transgenic Rodent Mutation and Comet Assay using the Benchmark Dose Approach** Hernandez LG, Slob W, van Steeg H, van Benthem
2:30 PM–2:45 PM	Xenoantiandrogens: Risk Factors for Androgen Receptor Mutation in Hypospadias Jyothy A, Sharma V, Venkateshwari A, Munshi A, Sujatha M, Singh R, Thangaraj K
2:45 PM–3:00 PM	Reticulocyte Ratios Estimated by Manual and Flow-Based Methods in the Mammalian Micronucleus Test: A Need to Update the Guideline? LeBaron MJ, Schisler MR, Torous DK, Dertinger SD, Gollapudi BB
3:00 PM–3:15 PM	Novel Mechanism-Based Reporter Cell Systems for Assessment of Genotoxicity and Oxidative Stress Induction Hendriks G, Atallah M, Morolli B, van de Water B, Vrieling H
3:15 PM–3:30 PM	Metabolism and Genotoxicity of Food Contaminants: Description of a New Genotoxic Assay Audebert M, Riu A, Jacques C, Hillenweck A, Jamin E, Zalko D, Cravedi JP
3:30 PM–3:45 PM	Activating Chemical Carcinogens by Expressing Cytochrome P450 Polymorphisms in Budding Yeast Fasullo MT
3:45 PM–4:00 PM	The Genotoxicity of Titanium Dioxide and Cerium Dioxide Nanoparticles in Human Respiratory Epithelial Cells Prasad RY, Tennant AH, Kligerman AD, Blackman CF, DeMarini DM
4:00 PM–4:15 PM	*Particle Size Does Not Impact Genotoxic Properties of Nanomaterials In Vivo* in the Comet or Micronucleus Assays** Pfuhler S, Downs T, Jester J, Lynch M, Reeder R, Sarlo K
4:15 PM–4:30 PM
	Break	Texas Ballroom Foyer
4:30 PM–5:45 PM
	Symposium 13 Cytogenetics and EMS: The Shelly Wolff Legacy Chairperson: Shelia M. Galloway, Merck Research Laboratories	Texas Ballroom F
4:30 PM–4:45 PM	Introduction: Sheldon Wolff and His Continuing Influence on Cytogenetics and Environmental Sciences Shelia M. Galloway, Merck Research Laboratories
4:45 PM–5:05 PM	Chromosome Structure and Repair: The Early Years John Heddle, York University
5:05 PM–5:25 PM	SCE, and ABCW: The Language of Environmental Science William F. Morgan, Pacific Northwest National Laboratory
5:25 PM–5:45 PM	Low Dose Effects: The Final Frontier Jeffrey L. Schwartz, University of Washington
6:15 PM–7:15 PM
	EMS Award Lecture Base Excision Repair and Environmental Mutagenesis Award Recipient: Samuel H. Wilson, National Institute of Health Sciences	Texas Ballrom F
7:30 PM–11:00 PM
	EMS Banquet Awards Presentation by Michael Plewa	Texas Ballrom E
	Alexander Hollaender Award
	EMS Service Award
	Student Education Award
	Student and New Investigator Travel Awards
	Dancing to the Music of The Genotones