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Agenda Overview

Complex Systems in Biology and Risk Assessment

EMS President: Michael J. Plewa
Program Chair: Jeffrey L. Schwartz

(information subject to change)

Friday | Saturday | Sunday | Monday | Tuesday | Wednesday

Saturday, October 23, 2010
8:00 AM–6:00 PM
  Registration Texas Ballroom Foyer
8:00 AM–12:15 PM
 

Advancements in Applied Genetic Toxicology Workshop

Chairpersons:
Patricia A. Escobar, Boehringer Ingelheim Pharmaceuticals and
Krista L. Dobo, Pfizer Global R&D

Organized by the Applied Genetic Toxicology Special Interest Group

Contributing Sponsors: MolTox, Pfizer Inc., and sanofi aventis

Sponsored in part by: BioReliance Corporation

Texas Ballroom F

8:00 AM–8:10 AM Introduction
Patricia Escobar, Boehringer Ingelheim Pharmaceuticals 
 
Developing a Better Understanding of Structure Activity Relationships
8:10 AM–8:40 AM

Structure Activity Relationships Associated with Genotoxic Impurities of Pharmaceuticals
Michelle Kenyon, Pfizer Inc.

 
8:40 AM–9:10 AM Evaluating Genotoxicity SAR: Experience from Analysis of Pharmaceutical Impurities
Joel P. Bercu, Amgen Inc.
 
Alternative In Vitro Models for Genotoxicity Assessment  
9:10 AM–9:40 AM Novel In Vitro Genotoxicity Assays Using Reconstructed Human Tissues
Gladys Ouedraogo-Arras, L’Oreal
 
9:40 AM–10:10 AM Challenges of an Automated In Vitro MN in Mammalian Cell Lines
Jing Shi, BioReliance Corporation
 
10:10 AM–10:30 AM Break  
10:30 AM–11:00 AM Gamma-H2AX As a Biomarker of DNA Damage Induced by Genotoxic Agents
Asako J. Nakamura, National Cancer Institute, NIH
 
In Vivo Genotoxicity Testing
11:00 AM–11:30 AM Multi-Tissue, Multi-Endpoint Assessment of Genotoxicity Using an Integrated Study Design
Maik J. Schuler, Pfizer Global R & D
 
11:30 AM–12:00 NOON Assessment of Micronucleated Erythrocytes: From Mouse to Man
Jeffrey Bemis, Litron Laboratories
 
12:00 NOON–12:15 PM Boxed Lunch Pick-Up  
9:00 AM–12:00 NOON
  EMS Executive Board Meeting Sundance 1
9:30 AM–4:30 PM
 

Career Development Workshop

Chairpersons:
Meredith Crosby, Yale University, and
Jennifer Hobin, Federation of American Societies for Experimental Biology (FASEB)

Contributing Sponsors: Federation of American Societies for Experimental Biology (FASEB) and Research Corporation for Science Advancement

Texas Ballroom G

9:30 AM–9:50 AM Introduction and Overview
Meredith Crosby, Yale University
 
9:50 AM–10:30 AM Individual Development Plans
Jennifer Hobin, Federation of American Societies for Experimental Biology (FASEB)
 
10:30 AM–12:30 PM Roundtable Discussion 1: Research, Teaching, Administration, and Industry  
12:30 PM–1:30 PM Lunch on Your Own  
1:30 PM–3:30 PM Roundtable Discussion 2: Science Policy, Consulting, Journalism, Law, and Marketing  
3:30 PM–4:30 PM

Available Resources and Wrap-Up

 
12:15 PM–5:00 PM
 

Genotoxicity of Nanomaterials: Refining Strategies and Tests for Hazard Identification Workshop

Chairpersons:
Stefan J. Pfuhler, The Procter & Gamble Company and
Rosalie K. Elespuru, U.S. Food and Drug Administration

Organized by the ILSI/HESI Nanogenetox Working Group and the EMS Regulatory Task Force

Primary Sponsor: The Procter & Gamble Company
Contributing Sponsors: ILSI-HESI IVGT Project Committee and sanofi aventis

Texas Ballroom F

12:15 PM–12:30 PM Boxed Lunch Pick-Up  
12:30 PM–12:40 PM Introduction
Stefan Pfuhler, The Procter & Gamble Company
 
12:40 PM–1:05 PM Approaches and Caveats to Investigating the Genotoxicity of Nanomaterials
Shareen H. Doak, Swansea University
 
1:05 PM–1:30 PM Testing for Genotoxic Effects of Nanomaterials In Vitro and In Vivo
Robert Lansiedel, BASF
 
1:30 PM–1:50 PM Developing a Coordinated International Research Effort in Nano-Genotoxicology
Tim Singer, Health Canada
 
1:50 PM–2:00 PM Regulatory Issues Related to Genotoxicity Safety Assessment of Nanomaterials
Rosalie K. Elespuru, U.S. Food and Drug Administration
 
2:00 PM–2:10 PM The Principal Approaches to Genotoxic Hazard Assessment of Nanomaterials in Japan
Masamitsu Honma, National Institute of Health Sciences, Tokyo
 
2:15 PM–3:30 PM

Break-Out Groups:

 
  Group 1: Standard In Vitro Assays: Assessment/Strategy Development           
Leaders:
Marilyn J. Aardema, Marilyn Aardema Consulting LLC and Shareen H. Doak, Swansea University
Sundance 1
  Group 2: Standard In Vivo Assays: Assessment/Strategy Development
Leaders:
E. Maria Donner,
Dupont Haskell Laboratory and
Mugimane Manjanatha, National Center for Toxicological Research, U.S. FDA
Sundance 2
  Group 3: Integration of New Technologies: Which Ones and When are They Needed?
Leaders:
Micheline Kirsch-Volders, Vrije Universiteit Brussel and Masamitsu Honma, NIHS Japan
Texas Ballroom F
3:30 PM–3:45 PM Break  
3:45 PM–5:00 PM Break-Out Group Summaries, General Discussion and Consensus Development Texas Ballroom F
12:30 PM–4:00 PM
  EMS Council Meeting Stockyards 1
4:30 PM–6:30 PM
 

Welcome Reception and Student/New Investigator Poster Session

Sponsored in part by: Genetic Toxicology Association

Texas Ballroom E