Genetic Mutation That Leads To Lupus In Mice

Genetic mutation causes lupus in mice


Joann Sweasy, longtime EMGS member and previous SIG leader, is one of the Yale researchers who identified a genetic mutation that leads to lupus in mice. The discovery could open the way for development of therapies that target the mutation. The study appears in Cell Reports.

Systemic Lupus Erythematosus (SLE) is an autoimmune disease that causes widespread inflammation in internal organs as well as joints and the nervous system. It affects five million people around the world. The first sign of lupus may be severe joint pain or a butterfly-shaped rash on the face. There is no cure.

The research team focused on a gene known as POL B, which functions to repair breaks in DNA. Decreased POL B expression, which results in weakened DNA repair, has been linked to SLE.

To test whether this was true, researchers constructed mouse models with mutated POL B. They exhibited decreased expression and much slower DNA synthesis. The mice subsequently developed disease characteristics that strongly resemble SLE, including dermatitis and renal disease.

This finding implicates abnormal DNA repair as one of the causes of lupus in people. This mouse model of SLE will be useful to study how abnormal DNA repair is linked to lupus and to identify new drugs to treat this disease.

Senior author is Joann Sweasy, professor of therapeutic radiology and genetics at Yale School of Medicine. 

Other authors are Alireza G. Senejani1, Yanfeng Liu, Dawit Kidane, Stephen Maher, Caroline J Zeiss, Michael Kashgarian, Jennifer McNiff, Daniel Zelterman, and Alfred Bothwell of Yale; Hong-Jae Park of Janyang University, Seoul, Republic of Korea.

The study was supported by a grant from the National Institute of Environmental Health Sciences (grant number ES019179).




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