The March 2017 Editor's Choice article, "Tumor-Associated APE1 Variant Exhibits Reduced Complementation Efficiency, But Does Not Promote Cancer Cell Phenotypes" exemplifies the importance of the base excision repair protein APE1 in the preservation of cellular homeostasis and genomic integrity.
The January 2017 Editor's Choice article, "Developmental Programming: Interaction Between Prenatal BPA and Postnatal Overfeeding on Cardiac Tissue Gene Expression in Female Sheep" by Koneva et al., reveals a complex relationship between intrauterine BPA exposure and postnatal diet in sheep.
In their December 2016 Editor's Choice article, entitled "Human T Lymphocytes Bioactivate Heterocyclic Aromatic Amines by Forming DNA Adducts," Bellamri et al. report important new information that will inform the public about cancer risk associated with heterocyclic aromatic amines.
The October 2016 Editor's choice article is "Transcriptional benchmark dose modeling: Exploring how advances in chemical risk assessment may be applied to the radiation field" by Vinita Chauhan, Byron Kuo, James P. McNamee, Ruth C. Wilkins and Carole L. Yauk.
This Editor's Choice article by Dr. Myron Goodman, the 2015 EMGS Award Winner, discusses a historical and evolutionary perspective on the benefits of hypermutation and the stringent control mechanisms that regulate their occurrence in bacteria and humans.