In their October 2017 Editor's Choice article, "Perinatal lead (Pb) exposure results in sex and tissue-dependent adult DNA methylation alterations in murine IAP transposons," Luke Montrose and colleagues shed light on potential developmental origins of disease.
In their August 2017 Editor's Choice article, "Applying the erythrocyte Pig-a assay concept to rat epididymal sperm for germ cell mutagenicity evaluation," Zhiying Ji and Matthew LeBaron describe the potential of the sperm Pig-a assay for detecting germ cell mutagens using two case study chemicals.
The June 2017 Editor's Choice article, "Next Generation Testing Strategy for Assessment of Genomic Damage: A Conceptual Framework and Considerations" by Dearfield et al., proposes the future direction for genomic damage assessment.
In the April 2017 issue of Environmental and Molecular Mutagenesis, Yan Sha and coworkers at the Oregon Health & Science University and Vanderbilt University examined the impact of local sequence context and anomeric conformation (α or β) on Fapy-dG adduct-induced mutagenesis.
The March 2017 Editor's Choice article, "Tumor-Associated APE1 Variant Exhibits Reduced Complementation Efficiency, But Does Not Promote Cancer Cell Phenotypes" exemplifies the importance of the base excision repair protein APE1 in the preservation of cellular homeostasis and genomic integrity.