50th Anniversary of the Environmental Mutagenesis and Genomics Society Special Issue
Historical Highlights, Current Issues, and the Future of Environmental Mutagenesis
Concept: The foundational work in mutagenesis, leading to the creation of the EMGS, was based on mutation (primarily germ cell mutations) as the endpoint of regulatory concern. With the invention of the Ames assay, and the recognition of mutation as a driving event in carcinogenesis, regulatory agencies shifted to mutagenesis for hazard ID for potential carcinogens, with risk assessment based on probability of cancer as the outcome. However, we have now come full circle. It has become clear that mutation is associated with much more than just cancer, and as a result there is a renaissance in the idea that mutation, in and of itself, should be an endpoint of regulatory concern. This Special Issue will cover the evolution of the EMGS, current issues, and the future (including expansion beyond purely genetic effects).
Check back for more papers, which will appear on this page as they publish.
Guest Editors: Carole Yauk, Robert Heflich, David DeMarini