Environmental and Molecular Mutagenesis (EMM) Editor’s Choice - April 2011
The Editor’s Choice for April is “Follow-up actions from positive results of in vitro genetic toxicity testing” by Kerry L. Dearfield, Veronique Thybaud, Michael C. Cimino, Laura Custer, Andreas Czich, James S. Harvey, Susan Hester, James H. Kim, David Kirkland, Dan D. Levy, Elisabeth Lorge, Martha M. Moore, Gladys Ouédraogo-Arras, Maik Schuler, Willi Suter, Kevin Sweder, Kirk Tarlo, Jan van Benthem, Freddy van Goethem, and Kristine L. Witt.
This review by Dr. Dearfield et al. communicates the recommendations developed during two International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) workshops conducted in May 2008 and February 2009 by a review subgroup tasked with clarifying interpretation of positive in vitro genotoxicity tests and identifying appropriate follow-up actions. This comprehensive review identifies potentially confounding factors related to in vitro genotoxicity tests and includes a table, which summarizes the strengths and weakness of various genotoxicity testing methods.
The major thrust of the review, however, is aimed at communicating a six-step “decision process” for follow-up of clear in vitro positive test results. The article stresses the importance of using a weight of evidence approach, as well as considering multiple types of data, and not just genotoxicity data. Because this article captures the wisdom of international leaders in genetic toxicology and describes many “best practices” for genotoxicity testing, this review is required reading and a valuable resource for anyone working in this area. Environ. Mol. Mutagen. 52:177-204 (2011) ©2010 Wiley-Liss, Inc.