Environmental and Molecular Mutagenesis Editor's Choice - January 2015
The Editor's Choice for January is “Recognition and repair of chemically heterogeneous structures at DNA ends” by Sara N. Andres, Matthew J. Schellenberg, Bret D. Wallace, Percy Tumbale, and R. Scott Williams.
This Editor’s Choice article reviews the biochemistry that underlies how cells identify and repair spontaneous, radiation- and chemically-induced DNA damage that occurs at DNA ends. Such damage is complex in nature and their repair is similarly complex. The authors begin with a discussion of the sources of modified DNA termini. These include well know sources of damage such as radiation and reactive oxygen species as well as less appreciated sources such as genomic RNA-derived intermediates. Next the authors describe direct reversal and nucleolytic processing pathways that resolve these DNA end alterations, and how cells coordinate these different pathways. The well-referenced review highlights the complexity of DNA damage processes that lead to structural alterations at DNA ends, as well as the diverse array of pathways that recognize and repair this damage. The information in this review will impact investigations into cell responses to stress, evolutionary biology, neurology, aging, and oncology. Environ. Mol. Mutagen., 2014. © 2014 Wiley Periodicals, Inc.