Environmental and Molecular Mutagenesis Editor's Choice - June 2015
The Editor's Choice for June is "Structural Variation Mutagenesis of the Human Genome: Impact on Disease and Evolution” by James R. Lupski.
Copy Number Variants (CNV), defined as deletions or duplications of ~100bp to over a megabase, represent one of the most common modes of genetic variation. Surprisingly, it has only been recently that the clinical importance of CNV has been appreciated. Dr. Lupski, a pioneer in the field of CNV and genomic disorders, has written a very clear and complete review of what is known about how CNV’s develop, their role in gene evolution, their effects on human health, and their potential contribution to environmental mutagenesis and genomics research. Dr. Lupski’s review article is sure to become required reading for everyone who studies CNV. This important publication was highlighted as the Editor’s Choice article in the June edition of Environmental and Molecular Mutagenesis. Environ. Mol. Mutagen. 56:419-436,2015. © 2015 Wiley Periodicals, Inc.