Environmental and Molecular Mutagenesis Editor's Choice - July 2015
The Editor's Choice for July is “DNA Damage Foci: Meaning and Significance” by Kai Rothkamm, Stephen Barnard, Jayne Moquet, Michele Ellender, Zohaib Rana, and Susanne Burdak-Rothkamm."
DNA repair proteins accumulate and/or are modified at DNA double-strand breaks (DSBs), where they can be visualized within cells as “DNA damage foci.” In their Editor’s Choice review article, Rothkamm et al. describe succinctly the approaches being used to visualize and quantify DNA damage foci. They explain how the analysis of such foci has been integral for elucidating mechanisms of DSB repair and they go on to describe other areas of investigation made possible by this technology. Foci in peripheral blood cells are being used to identify individuals with DNA repair syndromes. Foci are being developed as biomarkers of genotoxic stress, used in monitoring the efficacy of anticancer therapies and predicting individual responses to radiation therapy. Rothkamm et al. describe ongoing efforts to standardize the measurement of radiation-induced foci, to enable biodosimetry following radiation exposure. Chemical exposures can also induce DSBs, directly or indirectly, and DNA damage foci are being exploited to assess the genetic impact of chemical exposures. Thus, the Environmental and Molecular Mutagenesis July 2015 Editor’s Choice review of “DNA Damage Foci: Meaning and Significance” will be useful for readers seeking a concise introduction, update, or reference on the state of science in the field of DNA damage foci. Environ. Mol. Mutagen. 56:491-504, 2015 © 2015 Wiley Periodicals, Inc.