Environmental and Molecular Mutagenesis (EMM) Editor's Choice - May 2012
The Editor's Choice for May is "Persistent Genomic Instability in Peripheral Blood Lymphocytes FromHodgkin Lymphoma Survivors" by C. Salas, A. Niembro, V. Lozano, E. Gallardo, B. Molina, S. Sánchez, S. Ramos, A. Carnevale, P. Pérez-Vera, R. Rivera Luna, and S. Frias.
As cure rates for Hodgkin lymphoma have increased, increased numbers of survivors are living with the long-term consequences of their anticancer treatments. Consequently, Salas and co-authors elected to investigate the effects of anticancer therapy (specifically MOPP therapy; nitrogen mustard, Oncovin, procarbazine, and prednisone) on genomic instability. To accomplish this, they examined chromosome instability, measured as aneuploidy, and gross chromosomal rearrangements in peripheral blood lymphocytes from Hodgkin lymphoma survivors treated with MOPP therapy, with and without radiation or additional chemotherapy. They compared treated Hodgkin lymphoma patients to patients before treatment and to healthy donors. Significant increases in structural chromosomal damage and gross chromosomal rearrangements were observed in the MOPP-treated patients, even though they may have been treated years before their lymphocytes were assessed. Thus, Salas and colleagues obtained evidence that genomic instability persists many years after therapy, and could be responsible for the secondary tumors that are observed in survivors of Hodgkin lymphoma. Environ. Mol. Mutagen. 53:271–280 Published 2012 Wiley Periodicals, Inc.