The mission of the Epigenomics Special Interest Group (SIG) is to provide a forum for discussion on epigenetics and epigenomics, a place for EMGS members interested in this topic to meet and share with one another, and an organized effort to promote epigenomics content at all EMGS meetings. The epigenome is the dynamic regulatory framework that controls the use of genomic information during development and tissue differentiation and governs the response of cells, tissues, organs, and individuals to their environment. Epigenetic modifications occur without a change to the underlying DNA sequence, and yet they are mitotically and in some cases meiotically heritable. Epigenetic mechanisms include but are not limited to DNA modifications (primarily cytosine methylation) and post-translational histone tail modifications (the ‘histone code’). This SIG seeks to represent all aspects of epigenomics from the targeted scale (i.e. DNA methylation of imprinted genes) to the full genome scale (i.e., genome-wide changes in chromatin accessibility) with a particular emphasis on how chemical and non-chemical environmental exposures alter the epigenome, thus influencing phenotype, health, aging and disease.