In their October 2021 EMM Editor's Choice, Revollo and colleagues optimized PacBio Single-Molecule, Real-Time (PB SMRT) sequencing (background mutation rate ≤ 1 × 10−7 mutations per base pair) and successfully measure rare substitution mutations in E. coli cultures exposed to EMS and ENU.
Of time, space, and linear models—In their April 2022 EMM Editor's Choice, Nwanaji-Enwerem and colleagues attempted to quantify the genomic wear-and-tear effect of being exposed to space radiation. The question the authors asked is: “How much faster do cells age when exposed to space radiation?”
In their March 2022 EMM Editor’s Choice article, Cho et al. present an AOP network that links oxidative damage to induce mutations and chromosomal aberrations.
In their January 2022 EMM Editor’s Choice article, Waters et al. propose that the genotoxicity of molnupiravir (MOV), an antiviral with emergency use authorization for COVID-19 treatment, should be further investigated using human-centric methods before final FDA approval.
In their November 2021 EMM Editor’s Choice article, Mittelstaedt et al. demonstrate a tissue-specific, life-stage effect in EMS-induced genotoxicity between gpt-delta mice treated as adults and neonates.
