In their November 2021 EMM Editor’s Choice article, Mittelstaedt et al. demonstrate a tissue-specific, life-stage effect in EMS-induced genotoxicity between gpt-delta mice treated as adults and neonates.
In their August 2021 EMM Editor’s Choice article, Wang et al. demonstrate lead exposure in occupationally-exposed humans is associated with genotoxicity, and epigenetic mechanisms play a role in the lead-mediated genotoxicity.
In their July 2021 Editor’s Choice article, “Design of a digital-PCR assay to quantify fragmented human mitochondrial DNA,” Mosquera et al. describe an assay for the quantification of mtDNA copy number and DSBs resulting from biological processes or exposure to potential mitochondrial toxicants.