The February 2018 Editor's Choice article is "Quantitative differentiation of whole smoke solution-induced mutagenicity in the mouse lymphoma assay,” Xiaoqing Guo, Robert H. Heflich, Stacey L. Dial, Mamata De, Patricia A. Richter, and Nan Mei.
Additional scientific evidence can determine the negative public health impact of different tobacco products. Specifically, an approach to reliably quantify the mutagenicity of tobacco smoke, which has been classified by the International Agency for Research on Cancer as a human carcinogen, would be useful. In their Editor’s Choice Article, Guo et al. report using the mouse lymphoma assay (MLA) to evaluate the mutagenicity of WSSs from two types of cigarettes, with and without S9 activation. A variety of analytic approaches were used to interpret the results, including determination of benchmark dose (BMD) and no observable genotoxic effect level. The different analytic approaches gave similar rank order of mutagenic potency, which was correlated with cigarette tar content. This work demonstrates that the mouse lymphoma assay combined with data analysis using the BMD approach is a useful method for quantifying the mutagenic potency of different WSSs.