Hanssen-Bauer and colleagues developed a model including three modes of base excision, according to which three distinct complexes form through recruitment of different base excision repair proteins onto an XRCC1 core complex.
This work by Hernández et al. compared the benchmark dose that caused a 10% increase in endpoint response for in vivo genotoxicity and organ-matched carcinogenicity, and demonstrated a correlation between the endpoints.
This work by Stiborová et al. provides a new level of understanding regarding the molecular mechanisms underlying the activation of aristolochic acid I, an important human carcinogen.
The research article by Drs. McKinzie and Parsons is unique, in that it directly measures induction of a mutation with established importance in the azoxymethane rat colon cancer model (K-Ras codon 12 GAT mutation) only one week after exposure.
Abraham and Brooks show for the first time that 8-oxo-7,8-dihydro-2’-deoxyadenosine (8-oxo-dA), within the appropriate target sequences, increased the binding of two transcription factors (NF-kappa B and CREB).
