This work by Hernández et al. compared the benchmark dose that caused a 10% increase in endpoint response for in vivo genotoxicity and organ-matched carcinogenicity, and demonstrated a correlation between the endpoints.
The research article by Drs. McKinzie and Parsons is unique, in that it directly measures induction of a mutation with established importance in the azoxymethane rat colon cancer model (K-Ras codon 12 GAT mutation) only one week after exposure.
Abraham and Brooks show for the first time that 8-oxo-7,8-dihydro-2’-deoxyadenosine (8-oxo-dA), within the appropriate target sequences, increased the binding of two transcription factors (NF-kappa B and CREB).