This work by Hernández et al. compared the benchmark dose that caused a 10% increase in endpoint response for in vivo genotoxicity and organ-matched carcinogenicity, and demonstrated a correlation between the endpoints.
This work by Stiborová et al. provides a new level of understanding regarding the molecular mechanisms underlying the activation of aristolochic acid I, an important human carcinogen.
The research article by Drs. McKinzie and Parsons is unique, in that it directly measures induction of a mutation with established importance in the azoxymethane rat colon cancer model (K-Ras codon 12 GAT mutation) only one week after exposure.
Abraham and Brooks show for the first time that 8-oxo-7,8-dihydro-2’-deoxyadenosine (8-oxo-dA), within the appropriate target sequences, increased the binding of two transcription factors (NF-kappa B and CREB).
The article stresses the importance of using a weight of evidence approach, as well as considering multiple types of data, and not just genotoxicity data.
