Abraham and Brooks show for the first time that 8-oxo-7,8-dihydro-2’-deoxyadenosine (8-oxo-dA), within the appropriate target sequences, increased the binding of two transcription factors (NF-kappa B and CREB).
The article stresses the importance of using a weight of evidence approach, as well as considering multiple types of data, and not just genotoxicity data.
Interviews with interested candidates will be conducted to further the search for the next EIC of EMM.
The Division of Extramural Research and Training (DERT) and the National Toxicology Program (NTP) are seeking input into key research areas for evaluating the combined effects of multiple environmental exposures (“mixtures”).
Environmental and Molecular Mutagenesis (EMM) Editor's Choice - March 2011