This work by Stiborová et al. provides a new level of understanding regarding the molecular mechanisms underlying the activation of aristolochic acid I, an important human carcinogen.
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The research article by Drs. McKinzie and Parsons is unique, in that it directly measures induction of a mutation with established importance in the azoxymethane rat colon cancer model (K-Ras codon 12 GAT mutation) only one week after exposure.
Abraham and Brooks show for the first time that 8-oxo-7,8-dihydro-2’-deoxyadenosine (8-oxo-dA), within the appropriate target sequences, increased the binding of two transcription factors (NF-kappa B and CREB).