In their July 2021 Editor’s Choice article, “Design of a digital-PCR assay to quantify fragmented human mitochondrial DNA,” Mosquera et al. describe an assay for the quantification of mtDNA copy number and DSBs resulting from biological processes or exposure to potential mitochondrial toxicants.
In their March 2021 Editor’s Choice article, Mehta et al. demonstrate DHA exposure can occur through use of sunless tanning products and e-cigarettes, and millimolar doses of the compound are genotoxic, cytotoxic and can induce metabolic reprogramming.
In their January 2021 Editor's Choice article, "A promising Ames battery for mutagenicity characterization of new dyes,” Umbuzeiro et al. propose a tiered approach for mutagenicity testing of low-quantity dyes utilizing a miniaturized Ames battery.
In their February 2021 Editor's Choice article, Allemang et al. compare classical and 21st century genotoxicity tools for a proof-of-concept combinatorial approach to genotoxicity risk assessment.
In their November 2020 Editor's Choice article, “Quantification of cancer driver mutations in human breast and lung DNA using targeted, error-corrected CarcSeq,” Harris et al. demonstrate spontaneously-occurring CDMs may serve as quantitative reporters of clonal expansion and carcinogenic effect.