Environmental Mutagenesis & Genomics Society
48th Annual Meeting, Raleigh, North Carolina
September 9-13, 2017 - Raleigh Convention Center
Environmental Health Sciences Bridging the Gap between
Exposure, Mechanism and Public Health
Welcome
The EMGS welcomes members and attendees from across the US and around the world. Our diversity is essential to our success, and as your national professional society, we are committed to providing a safe and supportive forum for the communication of world-class science. The EMGS Diversity and Inclusion committee sends a special welcome to members of the LGBT community. Please reach out to any member of the EMGS Diversity and Inclusion Committee with your comments or concerns.
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Agenda Overview
Environmental Health Sciences Bridging the Gap between Exposure, Mechanism and Public Health
EMGS President: Thomas E. Wilson
Program Chair: Robert W. Sobol
New Investigator Co-Chair: Natalie Gassman
Sunday, September 10, 2017
6:30 AM
Breakfast for SIGs
Outside SIG Rooms
7:00 AM–6:00 PM
Registration Open
(1:00 PM-1:30 PM Closed for Lunch)
(1:00 PM-1:30 PM Closed for Lunch)
Main Lobby
7:00 AM–6:00 PM
Speaker Ready Room Open
(1:00 PM-1:30 PM Closed for Lunch)
(1:00 PM-1:30 PM Closed for Lunch)
Room 307
7:00 AM-8:15 AM
Special Interest Group (SIG) Meetings:
Joint meeting: Applied Genetic Toxicology & Risk Assessment
Room 305AB
Applied Genetic Toxicology Leaders: Rosalie K. Elespuru, US Food and Drug Administration, Chair; Carolina Garcia-Canton, British America Tobacco, Co-Chair; and Julie Cox, University of Ottawa, Young Investigator Co-Chair Risk Assessment Leaders: Catherine Gibbons, US EPA, Chair; and Nikolai Chepelev, Health Canada, New Investigator Co-Chair
Heritable Mutation and Disease SIG
Room 306B
Leaders: Lucas Argueso, Co-Chair; Michael D. Waters, Co-Chair; and Marc Beal, Health Canada/Carleton University, New Investigator Co-Chair
Molecular Epidemiology SIG
Room 306A
Leaders: Ainsley Weston, The National Institute for Occupational Safety and Health, CDC, Chair; Margaret Pratt, Co-Chair; and Karen Yuen Northcote, University of California, Berkeley, Young Investigator Co-Chair
8:30 AM–9:30 AM
Keynote Speaker 2
Ins and Outs of Base Excision Repair
Samuel H. Wilson, NIEHS
Ins and Outs of Base Excision Repair
Samuel H. Wilson, NIEHS
Room Ballroom A
9:30 AM–10:00 AM
Coffee Break
Outside Poster Room
10:00 AM–12:15 PM
Symposium 1:
Molecular Insight during DNA Damage Processing
Molecular Insight during DNA Damage Processing
Room 301AB
Chairpersons: Bennett Van Houten, University of Pittsburgh Cancer Institute and Bret David Freudenthal, University of Kansas Medical Center
-10:00 AM
Mechanisms Regulating Poly(ADP-ribose) Polymerase Enzymes in the Cellular Response to DNA Damage
John Pascal, University of Montreal
John Pascal, University of Montreal
-10:30 AM
DNA Methylation Pattern at BRCA1 Gene is Disrupted by Environmentally-Induced Oxidative DNA Damage via DNA Base Excision Repair
Yuan Liu, Florida International University
Yuan Liu, Florida International University
-10:50 AM
Molecular Mechanisms of Double Strand Break Repair
Scott Williams, NIEHS/NIH
Scott Williams, NIEHS/NIH
-11:20 AM
APE1 Cleavage Mechanisms During DNA Repair
Amy M. Whitaker, University of Kansas Medical Center
Amy M. Whitaker, University of Kansas Medical Center
-11:40 AM
Watching PARP1 and APE1 Collaborate to Remove Abasic Sites at the Single Molecule Level
Bennett Van Houten, University of Pittsburgh Cancer Institute
Bennett Van Houten, University of Pittsburgh Cancer Institute
10:00 AM–12:15 PM
Symposium 2:
New Approaches and Considerations for Assessing Chemical Safety in a Computational and a High-Throughput in Vitro Toxicology World
New Approaches and Considerations for Assessing Chemical Safety in a Computational and a High-Throughput in Vitro Toxicology World
Room 303
Chairpersons: Russell Thomas, National Center for Computational Toxicology, US EPA and Warren Casey, National Institute of Environmental Health Sciences
-10:00 AM
Application of High-Throughput Transcriptomic Approaches for Identifying Chemical Mode-of-Action
Imran Shah, U.S. EPA
Imran Shah, U.S. EPA
-10:30 AM
Retrofitting High-Throughput in vitro Assays for Metabolic Competence
Steve Simmons, U.S. EPA Office of Research and Development
Steve Simmons, U.S. EPA Office of Research and Development
-10:50 AM
Development of Organotypic Culture Systems to Link Pathway Perturbations with Phenotypic Responses
Stephen Ferguson, NIH
Stephen Ferguson, NIH
-11:20 AM
Systematic Approaches to Biological/Chemical Read-Across for Hazard Identification
Grace Patlewicz, U.S. EPA
Grace Patlewicz, U.S. EPA
-11:40 AM
Computational Approaches for Identifying AOPs
Steve Edwards, U.S. EPA
Steve Edwards, U.S. EPA
10:00 AM–12:15 PM
Symposium 3:
The Unique Vulnerability of the Germline Epigenome: Towards Evidence of Transgenerational Inheritance? (Sponsored by Escher Fund for Autism)
The Unique Vulnerability of the Germline Epigenome: Towards Evidence of Transgenerational Inheritance? (Sponsored by Escher Fund for Autism)
Room 304
Chairpersons: Caren Weinhouse, Duke University and Patrick Allard, UCLA
-10:00 AM
Chromatin and Transcription Dynamics in Germline Stem Cells and Spermatogenesis
Sue Hammoud, University of Michigan
Sue Hammoud, University of Michigan
-10:30 AM
Ancestral and multi-generational consumption of the total Western diet in mice promotes colitis-associated colorectal cancer in third-generation offspring.
Sumira Phatak, Utah State University
Sumira Phatak, Utah State University
-10:50 AM
Altered Chromatin Structure and Transcription Underlies the Meiotic Arrest Seen in BRG1 Deficient Spermatocytes
Debashish Menon, UNC Chapel Hill
Debashish Menon, UNC Chapel Hill
-11:20 AM
Characterizing the impact of maternal vitamin D deficiency on epigenetic programming in the male germline
Folami Y. Ideraabdullah, UNC Chapel Hill
Folami Y. Ideraabdullah, UNC Chapel Hill
-11:40 AM
Environment and Gametic Epigenetic Reprogramming
Susan Murphy, Duke University Medical Center
Susan Murphy, Duke University Medical Center
10:00 AM–7:00 PM
Poster Hall Open
Room 302ABC
12:15 PM–1:45 PM
Lunch on Your Own
12:15 PM–1:45 PM
Student and New Investigator Luncheon
Dara Wilson-Grant, University of North Carolina at Chapel Hill
Sponsored by the Genetics and Environmental Mutagenesis Society of North Carolina (GEMS)
Dara Wilson-Grant, University of North Carolina at Chapel Hill
Sponsored by the Genetics and Environmental Mutagenesis Society of North Carolina (GEMS)
Room 306A
12:15 PM–1:45 PM
Environmental and Molecular Mutagenesis Editorial Board Meeting
Room 306C
1:45 PM–4:00 PM
Symposium 4:
Linking DNA Adducts with Mutational Signatures
Linking DNA Adducts with Mutational Signatures
Room 301AB
Chairperson: Arthur P. Grollman, Stony Brook University
-1:45 PM
Emerging Mass Spectrometric-based Technologies Designed to Measure DNA Adducts of Carcinogens in Humans
Robert Turesky, University of Minnesota
Robert Turesky, University of Minnesota
-2:15 PM
Genome-Wide Imprints of Human Carcinogens: Experimental Modeling in Support of Molecular Cancer Epidemiology
Jiri Zavadil, International Agency for Research on Cancer
Jiri Zavadil, International Agency for Research on Cancer
-2:35 PM
Mutational Signatures as Records of Carcinogen Exposure: Assigning Roles in Cancer Etiology
Thomas Allen Rosenquist, Stony Brook University
Thomas Allen Rosenquist, Stony Brook University
-3:05 PM
Translesion DNA Synthesis, A Key Factor In Determining Mutational Signatures In Human Cancer
Masaaki Moriya, Stony Brook University
Masaaki Moriya, Stony Brook University
-3:25 PM
Translesional Synthesis of Alkylated DNA Lesions in Cells
Yinsheng Wang, University of California at Riverside
Yinsheng Wang, University of California at Riverside
1:45 PM–4:00 PM
Symposium 5:
Novel Genomic Editing: CRISPR-Cas9 Application in Toxicology and Mechanistic Discovery
Novel Genomic Editing: CRISPR-Cas9 Application in Toxicology and Mechanistic Discovery
Room 303
Chairpersons: Luoping Zhang, University of California Berkeley and Rodolphe Barrangou, NCSU
-1:45 PM
CRISPR-Cas Systems: from Adaptive Immunity to Genome Editing Revolution
Rodolphe Barrangou, NCSU
Rodolphe Barrangou, NCSU
-2:15 PM
Functional Toxicogenomics of Exposures to Environmental Toxins by CRISPR
Christopher Vulpe, University of Florida
Christopher Vulpe, University of Florida
-2:35 PM
Introducing ToxCRISPR: A New Tool to Screen Toxic Chemicals
Quan Lu, Harvard University
Quan Lu, Harvard University
-3:05 PM
Application of Zinc Finger Nuclease Genome-Editing Therapy in Human Disease
Kathleen Meyer, Sangamo Therapeutics, Inc.
Kathleen Meyer, Sangamo Therapeutics, Inc.
-3:25 PM
Emerging Application of CRISPR-Cas9 in Toxicology and Environmental Health Sciences
Luoping Zhang, University of California Berkeley
Luoping Zhang, University of California Berkeley
1:45 PM–4:00 PM
Symposium 6:
Whole Exome Sequencing in Clinical and Environmental Disease
Whole Exome Sequencing in Clinical and Environmental Disease
Room 304
Chairpersons: Kristine L. Witt, NIEHS, NIH and B. Alex Merrick, NIEHS, NIH
-1:45 PM
Exome-seq for CVD Risk Variants
Donald Bowden, Wake Forest School of Medicine
Donald Bowden, Wake Forest School of Medicine
-2:15 PM
A Reporter System for Screening Environmental and Genetic Risk Factors for Non-Recurrent CNV Formation.
Martin Arlt, University of Michigan
Martin Arlt, University of Michigan
-2:35 PM
Genomic Bioinformatics in Disease: Analytical/Visual Methods Development, Experimental Design, and Software Implementation to Distill Useful Information from Epidemiological Studies of Human Health
David Reif, NC State University
David Reif, NC State University
-3:05 PM
Frequent Mutational Signature of Aristolochic-acid Derivatives in Hepatocellular Carcinomas in Asia and Taiwan
Steven G. Rozen, Duke-NUS Medical School
Steven G. Rozen, Duke-NUS Medical School
-3:25 PM
Tumor Profiling via Next Generation Sequencing to Help Determine Options for Targeted Therapy and Inform Prognosis; Molecular Genetic Pathology
Nirali Patel, University of North Carolina at Chapel Hill
Nirali Patel, University of North Carolina at Chapel Hill
4:00 PM–4:30 PM
Flash Talks
Room 301AB
4:30 PM–6:30 PM
Poster Session 1
Room 302ABC
6:30 PM–10:00 PM
Crank Arm Brewing