Environmental Mutagenesis & Genomics Society

48th Annual Meeting, Raleigh, North Carolina

September 9-13, 2017 - Raleigh Convention Center

Environmental Health Sciences Bridging the Gap between
Exposure, Mechanism and Public Health



The EMGS welcomes members and attendees from across the US and around the world. Our diversity is essential to our success, and as your national professional society, we are committed to providing a safe and supportive forum for the communication of world-class science. The EMGS Diversity and Inclusion committee sends a special welcome to members of the LGBT community.  Please reach out to any member of the EMGS Diversity and Inclusion Committee with your comments or concerns.

View our EMGS Young Scientist video presentations

Agenda Overview

Environmental Health Sciences Bridging the Gap between Exposure, Mechanism and Public Health

EMGS President: Thomas E. Wilson
Program Chair: 
Robert W. Sobol
New Investigator Co-Chair:
Natalie Gassman

Monday, September 11, 2017

6:30 AM
Breakfast for SIGs
Outside SIG Rooms

7:00 AM–5:00 PM
Registration Open
(1:00 PM-1:30 PM Closed for Lunch)
Main Lobby

7:00 AM–5:00 PM
Speaker Ready Room Open
(1:00 PM-1:30 PM Closed for Lunch)
Room 307

7:00 AM-8:15 AM
Special Interest Group (SIG) Meetings:

DNA Repair & Mutagenic Mechanisms SIG
Room 305AB
Leaders: Natalie Gassman, University of South Alabama, Chair; and Zachary Nagel, Harvard School of Public Health, Young Investigator Co-Chair

Environmental Genetic Toxicology SIG
Room 306B
Leaders: Jeffrey Wickliffe, Tulane University, Chair; Mark Wilson, Tulane University

New Technologies SIG
Room 306A
Leaders: Patricia Escobar, Merck Research Laboratories, Chair; Stephanie L. Smith-Roe, National Toxicology Program, Co-Chair; Raymond R. Tice, RTice Consulting, Co-Chair; Le Ngo, MIT, Student Co-Chair

8:00 AM–7:00 PM
Poster Hall Open
Room 302ABC

8:30 AM–9:30 AM
Keynote Speaker 3
Alternative Recombination Mechanisms Control ALTernative Telomere Length Maintenance
Roger Greenberg, University of Pennsylvania
Room Ballroom A

9:30 AM–10:00 AM
Coffee Break
Outside Poster Room

10:00 AM–12:15 PM
Symposium 7:
Cross Talk between Telomere Biology and DNA Repair: from Molecules to Humans
Room 301AB
Chairpersons: Patricia L. Opresko, University of Pittsburgh and Joann B. Sweasy, Yale University School of Medicine
-10:00 AM
Visualizing Telomere Structure and Architecture
Jack Griffith, University of North Carolina
-10:30 AM
Unreaveling Secrets of Telomeres: One Molecule at a Time
Hong Wang, North Carolina State University
-10:50 AM
Oxidative DNA Damage and Repair at Telomeres
Patricia L. Opresko, University of Pittsburgh
-11:20 AM
A Single Amino Acid Mutation in the N-terminal Domain of the Human DNA Glycosylase NTHL1 Reveals Novel Role in Telomere Maintenance
Carolyn Marsden, University of VermontUniversity
-11:40 AM
Telomere Syndromes and Telomere Dysfunction in Human Disease
Sharon Savage, NIEHS/NIH

10:00 AM–12:15 PM
Symposium 8:
Mosaic Mutations in Humans and Risk for Disease
Room 303
Chairpersons: George R. Douglas, Health Canada and Francesco Marchetti, Health Canada
-10:00 AM
Somatic Gene Mutation and Human Disease Other than Cancer
Robert Erickson, University of Arizona
-10:30 AM
In Utero Exposure to Benzo(a)pyrene Induces Somatic and Germ Cell Mosacism in the Mouse
Francesco Marchetti, Health Canada
-10:50 AM
Understanding the Mechanisms of Human Genomic Rearrangements Using Phenotypic Extremes
Pengfei Liu, Baylor College of Medicine
-11:20 AM
Clock-like and Mosaic Mutational Processes in Human Somatic Cells
Ludmil B Alexandrov, Los Alamos National Laboratory
-11:40 AM
Mutation Load and Mutation Signatures in Human Somatic Cells
Dimitry Gordenin, NIEHS NIH

10:00 AM–12:15 PM
Symposium 9:
Integrated Genotoxicity Testing Strategies: Practical Applications of Toxicogenomics (Sponsored by MilliporeSigma BioReliance(R) Services)
Room 304
Chairperson: Carole L. Yauk, Health Canada
-10:00 AM
Case Studies on the Integration of Toxicogenomics Biomarkers into Genetic Toxicology Assesment
Carole L. Yauk, Health Canada
-10:30 AM
Predicting Genotoxic Mode of Action Using Connectivity Mapping (CMap): Impact of Gene Array Platform and Dose Selection
Ashley Allemang, The Procter & Gamble Company
-10:50 AM
Technological Advances in the Genetic Toxicology Gene Expression Biomarkers: Today, Tomorrow, and Beyond
Heng Hong Li, Georgetown University
-11:20 AM
SWOT Analysis of Toxicogenomics Approaches to Identify Genotoxic Modes of Action in Mammalian Cells: An ILSI-HESI Workshop Report
Laura L. Custer, Bristol-Myers Squibb
-11:40 AM
The HESI TGx-28.65 Genomic Biomarker to Detect DNA Damage-Inducing Agents: Development and Validation Status
Jiri Aubrecht, Pfizer

12:15 PM–1:45 PM
Lunch on Your Own

12:15 PM–1:45 PM
Women in the EMGS Luncheon
My Career: A Winding Path
Linda Birnbaum, NIEHS & NTP
Room 306A

1:45 PM–3:30 PM
Platform Session 1:
Effects of Environmental Exposures on Mitochondria
Room 301AB
Chairpersons: Joel N. Meyer, Duke University and Tess C Leuthner, Duke University
-1:45 PM
Mitochondrial function changes the epigenetic landscape and regulates gene transcription
Janine Santos, NIEHS, NIH
-2:10 PM
Human trichloroethylene exposure is associated with increased blood buffy-coat derived mitochondrial DNA damage
Laurie Sanders, Duke University Medical Center
-2:35 PM
Adaptation to cadmium reveals mechanism and susceptibility to mitochondrial genotoxicity
Tess Leuthner, Duke University
-3:00 PM
Structure and dynamics of DNA unwinding in mitochondria
Parminder Kaur, North Carolina State University

1:45 PM–3:30 PM
Platform Session 2:
Epigenetics and DNA Repair Dynamics
Room 303
Chairpersons: Brian Chorley, US EPA and Mercedes E. Arana, NIEHS
-1:45 PM
SIRT2 Directs DNA-PKcs in the DNA Damage Response
PamelaSara Elbaz Head, Emory University
-2:10 PM
The Lysine Demethylase KDM2B Enhances the DNA Damage Response to Ionizing Radiation
Alyssa Bernanke, Duke University
-2:35 PM
Genome-wide Analysis of Oxidative Stress-induced Mutation in the Context of Nucleosome Composition
Richard Nathan Keith, Indiana University
-3:00 PM
Chronic exposure to particulate chromate induces altered growth parameters and chromosome instability in human lung cells
Sandra Wise, University of Louisville

1:45 PM–3:30 PM
Platform Session 3:
Advances in Metabolic Activation for Genetic Toxicity Testing
Room 304
Chairpersons: Stephanie L. Smith-Roe, National Toxicology Program
-1:45 PM
Hepatocytes As A Metabolic Activating System And Target Organ For Genotoxicity Testing
Martin Blake Phillips, ScitoVation, LLC 
-2:10 PM
Organotypic In Vitro Models and High-throughput Transcriptomics in Genetic Toxicology Research
Sreeni Ramaiahgari, National Toxicology Program
-2:35 PM
Metabolically Competent HepaRG™ Cells Are a Viable Human Hepatocyte Model for In Vitro Genetic Toxicity Testing
Carol Swartz, Integrated Laboratory Systems
-3:00 PM
High Information Content Flow Cytometry-Based Rat Liver Micronucleus Assay—Simultaneous Assessment of Cytogenetic Damage and Hepatocyte Proliferation
Stephen D. Dertinger, Litron Laboratories

3:45 PM–4:30 PM
2017 Young Scientist Award Winner Plenary Lecture
The Impact of Environmental and Endogenous Damage on Human Somatic Mutation Load
Natalie Saini, National Institute of Environmental Health Sciences
Room 301AB

4:30 PM–6:30 PM
Poster Session 2
Room 302ABC