Environmental Mutagenesis & Genomics Society
49th Annual Meeting, San Antonio, Texas
September 22-26, 2018 - Hyatt Regency San Antonio
Maintaining Genomic Integrity in the Face of Environmental Insult
EMGS 2018
Meeting Microsite
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Welcome
The EMGS welcomes members and attendees from across the US and around the world. Our diversity is essential to our success, and as your national professional society, we are committed to providing a safe and supportive forum for the communication of world-class science. The EMGS Diversity and Inclusion committee sends a special welcome to members of the LGBT community. Please reach out to any member of the EMGS Diversity and Inclusion Committee with your comments or concerns.
View Past Annual Meeting abstracts.
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Announced in: San Antonio, TX
2018 EMGS Annual Meeting
Maintaining Genomic Integrity in the Face of Environmental Insult
Tuesday, September 25, 2018
6:30- 7:00 AM
Breakfast for SIG/Committee meeting attendees
7:00- 8:15 AM
SIG Meeting
Risk Assessment
Regency East 2
SIG Meeting
Transgenics & In Vivo Mutagenesis
Regency East 1
Committee Meeting
Annual Meeting Publicity
Regency East 3
8:30- 9:30 AM
Plenary Lecture
EMGS Award Winner
Xeroderma pigmentosum – When the lifeguard for the gene pool goes on strike
Kenneth Kraemer, National Cancer Institute
Regency West
10:00- 12:00 PM
Symposium 8: Environmental Exposure, Genotoxicity and Cancer Risk in Whales
Chairpersons: John Pierce Wise Sr. and Daniel Martineau
10:00-10:40
A Whale of Tale: Metals and Genotoxicity in Great Whales from a One Health Approach
John Pierce Wise, University of Louisville
10:40-11:20
High Rates of Cancers in the Human and the Beluga Whale Populations of Saguenay Lac Saint-Jean, Quebec, both Extensively Exposed to PAHs, Exemplify the One Health Concept
Daniel Martineau, University of Montreal
11:20-12:00
UV-induced Damage and Photoprotection in Whales
Blanca Morales-Guerrero
Regency West 4/5
Symposium 9: Defining the spectrum of human germline variability, and exploring its environmental stimulation
Chairpersons: J. Lucas Argueso and Lizzie Ngo
10:00-10:35
Clinical incidence of germline mutations in humans
James Lupski, Baylor College of Medicine
10:35-11:10
Global patterns of germline mutagenesis in eukaryotes
Michael Lynch, Arizona State University
11:10-11:35
Absence of selection against ENU-induced point mutations in male germ cells during transmission to the next generation
Kenichi Masumura, National Institute of Health Sciences
11:35-12:00
Panel Discussion
Regency West 6
Platform 4: Mutagenesis
Chairpersons: Daniel Roberts and Page McKinzie
10:00-10:20
Missense mutations in TDP-43 and its adverse effects on genome damage repair: Implications in neurodegenerative disorders
Joy Mitra, Houston Methodist Research Institute
10:20-10:40
A systematic evaluation of the mutagenic properties of 8-oxoguanine as a function of trinucleotide sequence context
Bogdan I Fedeles, Massachusetts Institute of Technology
10:40-11:00
Genomic profiling of high-grade serous ovarian cancer cases reveals potential drivers of chromosomal instability
Irina Kovtun, Mayo Clinic
11:00-11:20
Genome-wide mutational signature of glycidamide observed in human cancers using PCAWG data
Maria M. Zhivagui, International Agency for Research on Cancer
11:20-11:40
Quantification of Actionable Cancer-Driver Mutations in African American Normal Breast and Breast Cancers, Including Triple Negative Breast Cancer
Meagan Myers, US FDA/NCTR
11:40-12:00
Methodological and Computational Approaches to using NGS for Mutation Quantitation
Page B. McKinzie, National Center for Toxicological Research
Regency East 3
12:00- 1:30 PM
SIG Meeting
Environmental Genetic Toxicology
Regency East 1
SIG Meeting
Molecular Epidemiology
Regency East 2
SIG Meeting
DNA Repair
Regency East 3
1:30- 3:30 PM
Symposium 10: Assessing, Understanding and Managing the Risks Posed by Carcinogenic PAH Mixtures
Chairpersons: Margaret Pratt and Paul White
1:30-1:35
Introduction
1:35-1:55
PAH Mixtures Cancer Risk Estimation: Implementing Peer Review Recommendations and Looking Ahead
Margaret Pratt, US EPA
1:55-2:15
The Good, the Bad, and the Ugly: Polycyclic Aromatic Hydrocarbon Screening and Testing
Cynthia Rider, NTP/NIEHS
2:15-2:35
Genetic Toxicity of Complex Mixtures of Polycyclic Aromatic Hydrocarbons: Evaluating Dose-Additivity in a Transgenic Mouse Model
Alexandra Long, Health Canada
2:35-2:55
Improving Evaluation of Carcinogenic Risk for Mixtures with Systems Biology Data
Susan Tilton, Oregon State University
2:55-3:15
Remediation of a PAH-contaminated Former MGP (Manufactured Gas Plant) Site
Stephen Pinto, QM Environmental
3:15-3:30
Questions and Discussion
Regency West 4/5
Symposium 11: The Power and Promise of in vitro 3D Models for Toxicological Testing
Chairpersons: Malathi Banda and Marilyn Aardema
1:30-1:35
Introduction
1:35-2:00
Review of the Use of 3D Skin Tissue models for Genotoxicity Testing
Stefan Pfuhler, Proctor and Gamble
2:00-2:20
3D Skin Micronucleus and Comet Assay for genetox positive compound: A Case Study
Shambhu Roy, MilliporeSigma
2:20-2:40
Latest Developments in Genotoxicity Testing in Non-Skin 3D Tissue Models
Jan van Benthem, National Institute for Public Health and the Environment, The Netherlands
2:40-3:00
Airway Model for Testing Inhaled Chemicals
Xuefei Cao, National Center for Toxicological Testing, US FDA
3:00-3:20
Establishing a Primary Lung Cancer Model to Identify Mutant Subpopulations That Cause Resistance to Molecularly- Targeted Cancer Therapies
Malathi Banda, Covance Laboratories Inc.
3:20-3:30
Questions/Discussion
Regency West 6
Platform 5: DNA Repair 1
Chairpersons: Leslyn Hanakahi and Shobhan Gaddameedhi
1:30-1:50
Promotion of error-free transcriptional bypass of DNA lesions is essential for Rad26 to facilitate transcription coupled DNA repair
Kathiresan Selvam, Louisiana State University
1:50-2:10
Role of DNA Repair Proteins in Promoting Formation of Chromosomal Translocation
Anindita Ghosh, University of North Carolina at Charlotte
2:10-2:30
TDP-43 as a novel adjuvant target for radioimmunotherapeutic treatment of B16 melanoma
Juan Rodrigo Trujillo, Rice University
2:30-2:50
A guardian residue hinders insertion of a Fapy•dGTP analogue by modulating the open-closed DNA polymerase transition
Bret David Freudenthal, University of Kansas Medical Center
2:50-3:10
Regulation of BRCA1 by SIRT2
Elizabeth Minten, Emory University
3:10-3:30
Single-strand break end resection in genome integrity: from concept to mechanism
Shan Yan, University of North Carolina at Charlotte
Regency East 3
3:45- 4:45 PM
Plenary Lecture
Young Scientist Award Winner
Structural and biochemical studies to assess protein interactions and classify VUSs
Aishwarya Prakash, Mitchell Cancer Institute