EMGS Workshops

Heritable Hazards of Smoking: Applying the “Clean Sheet” Framework to Further Science and Policy

Co-Chairs: Francesco Marchetti, Health Canada, Jill Escher, Escher Fund for Autism, Young Investigator Co-chair: Abigail Bline, UCLA

Organizing Committee: Abigail Bline, UCLA, Kerry Dearfield, Retired (formerly at USDA and EPA), David DeMarini, US EPA, Jill Escher, Francesco Marchetti, Carole Yauk, Health Canada

Room: Statler

8:45-9:00 AM
Welcome, Opening Remarks, and Introductions
Jill Escher, Escher Fund for Autism

9:00-9:20 AM
The Clean Sheet Initiative and Its Potential to Identify the Risks of Heritable Consequences of Tobacco Smoke Exposures
Kerry L. Dearfield, Retired (formerly at USDA and EPA), Burke, VA

9:20-9:40 AM
Rationale for This Workshop: Growing Concern Regarding Heritable and Intergenerational Effects from Environmental Exposures
Carole L. Yauk, Health Canada

9:40-10:00 AM
The Potentially Vulnerable Periods of Exposure to the Male and Female Germline
Jacquetta Trasler, McGill University, Montreal, ON, Canada

10:00-10:20 AM
Break

10:20-10:40 AM
Tobacco Smoke Exposure: Hazardous Components of Tobacco and Related products; Broad Overview of Known Health Effects; Tobacco-Induced Male Germ Cell and Heritable Effects
Francesco Marchetti, Health Canada

10:40-11:00 AM
Male-Mediated Heritable Epigenetic Effects
Jacquetta Trasler, McGill University, Montreal, ON, Canada

11:00-11:20 AM
Overview of Asthma and Allergy Epidemiology: Epigenetic Studies of Transgenerational Effects of Smoking
John Holloway, University of Southhampton, UK

11:20-11:40 AM
Multigenerational Transmission of Hyperactivity/ADHD
Pradeep Bhide, Florida State University, Tallahassee, FL, USA

11:40-11:50
Grandmaternal Smoking and Risk for ADHD
Gyeyoon Yim, ScD candidate, Harvard T.H. Chan School of Public Health, MA, USA

11:50-12:10 PM
The RHINESSA Cohort, a Three-Generation Study on the Association of Tobacco Smoking with Asthma
Cecillie Svanes, University of Bergen, Norway

12:10-12:30 PM
Panel Discussion of the Evidence

12:30-1:30 PM
Lunch (provided)

1:30-2:00 PM
Toxicology of E-cigarettes
Ilona Jaspers, University of North Carolina, NC, USA

2:00-2:30 PM
Discussants
Implications for Bioethics
Anne Le Goff, Institute for Society and Genetics, UCLA, CA, USA
Implications for Public Health Advocacy
Laurent Huber, Executive Director, ASH, Washington, DC, USA

2:30-3:30 PM
Directed Discussion and Consensus Opinion
Methods and data to study intergenerational effects of these products and how to apply the Clean Sheet Framework. Is there a need for regulatory policy to emphasize germ cell risk in addition to somatic cell risk? Next steps?