Environmental Mutagenesis & Genomics Society

50th Annual Meeting, Washington DC

September 19-23, 2019 - Capital Hilton Washington DC

Environmental Mutagenesis and Genomics: The Next Fifty Years

Special Symposium

 Important Dates


3/4/19-Registration is now Open
7/27/19-Early Bird Registration Ends
8/19/19-Advanced Registration Ends


2/22/19-Abstract Submission is now Open
5/15/19-Abstract Submission Deadline
8/29/19-Late Abstracts Deadline

Travel Awards

Travel Award Form Available
5/15/19-Travel Award Deadline

Hotel Information

2/27/19-Reservations Open
8/21/19-Reservation Deadline

Young Scientist Award

EMGS Welcomes You

The EMGS welcomes members and attendees from across the US and around the world. Our diversity is essential to our success, and as your national professional society, we are committed to providing a safe and supportive forum for the communication of world-class science. The EMGS Diversity and Inclusion committee sends a special welcome to members of the LGBT community.  Please reach out to any member of the EMGS Diversity and Inclusion Committee with your comments.

EMGS Workshops

September 19th, 2019

3:00 PM - 5:00 PM

Council Meeting
Room: Massachusetts

8:00 AM - 12:00 PM

Scientific and Regulatory Updates on Non-Mutagenic and Mutagenic Impurities in Pharmaceuticals

Chair: Patricia Escobar, Merck Inc. and Brinda Mahadevan, Abbot

Room: Pan American

8:00-8:10 AM
Brinda Mahadevan, Abbott Healthcare Pvt. Ltd, Mumbai, India

8:10-8:40 AM
Update of IQ Consortium – Non Mutagenic Impurities (NMI)

Joel Bercu, Gilead USA

8:40-9:10 AM
Considerations for Deriving Non-Mutagenic (NMI) Exposure Limits

Mark Powley, Merck & Co., Inc., USA 

9:10-9:40 AM
Regulatory perspective on Non-mutagenic impurities (NMI) 

Tim McGovern, FDA

9:40-10:00 AM

10:00-10:30 AM
Update on the DrugSafe IQ consortium on mutagenic Impurities (QSAR review of impurities)

John Nicolette, AbbVie USA

10:30-11:00 AM
ICH M7 and Biotherapeutics: Out of Scope but Relevant
Zhanna Sobol, Pfizer USA

11:00-11:30 AM
Regulatory Perspective on Mutagenic Impurities and ICH M7

Roland Frotschl, EMA, bfarm, Germany

11:30-11:50 AM
Q&A followed by a panel discussion

8:45 AM - 3:30 PM

Heritable Hazards of Smoking: Applying the “Clean Sheet” Framework to Further Science and Policy

Co-Chairs: Francesco Marchetti, Health Canada, Jill Escher, Escher Fund for Autism, Young Investigator Co-chair: Abigail Bline, UCLA

Organizing Committee: Abigail Bline, UCLA, Kerry Dearfield, Retired (formerly at USDA and EPA), David DeMarini, US EPA, Jill Escher, Francesco Marchetti, Carole Yauk, Health Canada

Room: Statler

8:45-9:00 AM
Welcome, Opening Remarks, and Introductions
Jill Escher, Escher Fund for Autism

9:00-9:20 AM
The Clean Sheet Initiative and Its Potential to Identify the Risks of Heritable Consequences of Tobacco Smoke Exposures
Kerry L. Dearfield, Retired (formerly at USDA and EPA), Burke, VA

9:20-9:40 AM
Rationale for This Workshop: Growing Concern Regarding Heritable and Intergenerational Effects from Environmental Exposures
Carole L. Yauk, Health Canada

9:40-10:00 AM
The Potentially Vulnerable Periods of Exposure to the Male and Female Germline
Jacquetta Trasler, McGill University, Montreal, ON, Canada

10:00-10:20 AM

10:20-10:40 AM
Tobacco Smoke Exposure: Hazardous Components of Tobacco and Related products; Broad Overview of Known Health Effects; Tobacco-Induced Male Germ Cell and Heritable Effects
Francesco Marchetti, Health Canada

10:40-11:00 AM
Male-Mediated Heritable Epigenetic Effects
Jacquetta Trasler, McGill University, Montreal, ON, Canada

11:00-11:20 AM
Overview of Asthma and Allergy Epidemiology: Epigenetic Studies of Transgenerational Effects of Smoking
John Holloway, University of Southhampton, UK

11:20-11:40 AM
Multigenerational Transmission of Hyperactivity/ADHD
Pradeep Bhide, Florida State University, Tallahassee, FL, USA

Grandmaternal Smoking and Risk for ADHD
Gyeyoon Yim, ScD candidate, Harvard T.H. Chan School of Public Health, MA, USA

11:50-12:10 PM
The RHINESSA Cohort, a Three-Generation Study on the Association of Tobacco Smoking with Asthma
Cecillie Svanes, University of Bergen, Norway

12:10-12:30 PM
Panel Discussion of the Evidence

12:30-1:30 PM
Lunch (provided)

1:30-2:00 PM
Toxicology of E-cigarettes
Ilona Jaspers, University of North Carolina, NC, USA

2:00-2:30 PM
Implications for Bioethics
Anne Le Goff, Institute for Society and Genetics, UCLA, CA, USA
Implications for Public Health Advocacy
Laurent Huber, Executive Director, ASH, Washington, DC, USA

2:30-3:30 PM
Directed Discussion and Consensus Opinion
Methods and data to study intergenerational effects of these products and how to apply the Clean Sheet Framework. Is there a need for regulatory policy to emphasize germ cell risk in addition to somatic cell risk? Next steps?

12:00 - 4:30 PM

OECD Assessment of Miniaturized Ames Assays: Results and Recommendations

Co-chairs: Birgit Mertens, Sciensano, Brussels, Belgium, Leon F. Stankowski, Jr. Charles River Laboratories, Skokie, IL, USA

Room: New York

12:00-12:15 PM
Pick up Box Lunch (provided)

12:15-12:30 PM
Overview of OECD Process to Evaluate Miniaturized Ames Assays 
Birgit Mertens, Sciensano, Brussels, Belgium

12:30-1:00 PM
The 6-Well Ames Assay
John Nicolette, AbbVie, North Chicago, IL, USA

1:00-1:30 PM
The 24-Well Ames Assay
Leon F. Stankowski, Jr., Charles River Laboratories, Skokie, IL, USA

1:30-2:00 PM
The Ames II/MPF Assay
Kamala Pant, BioReliance, Rockville, MD, USA

2:00-2:30 PM
Technical Comparisons Among Assays
Birgit Mertens, Sciensano, Brussels, Belgium

2:30-3:00 PM
Coffee Break

3:00-3:45 PM
Qualitative and Quantitative Comparisons of Assays
Paul White, Health Canada

3:45-4:30 PM
Discussion and Closing Summary
Birgit Mertens, Sciensano, Brussels, Belgium

5:30 PM - 6:45 PM

EMGS President's Reception
Room: Congressional

7:00 PM - 8:00 PM

EMGS Presidential Keynote Address

The Fidelity of Eukaryotic Nuclear DNA Replication
Thomas A. Kunkel, NIH Distinguished Investigator

Room: Presidential Ballroom