Environmental Mutagenesis & Genomics Society

50th Annual Meeting, Washington DC

September 19-23, 2019 - Capital Hilton Washington DC

Environmental Mutagenesis and Genomics: The Next Fifty Years

Special Symposium
Registration

 Important Dates

Registration

3/4/19-Registration is now Open
7/27/19-Early Bird Registration Ends
8/19/19-Advanced Registration Ends

Abstracts

2/22/19-Abstract Submission is now Open
5/15/19-Abstract Submission Deadline
8/29/19-Late Abstracts Deadline

Travel Awards

Travel Award Form Available
5/15/19-Travel Award Deadline

Hotel Information

2/27/19-Reservations Open
8/21/19-Reservation Deadline

Young Scientist Award


EMGS Welcomes You

The EMGS welcomes members and attendees from across the US and around the world. Our diversity is essential to our success, and as your national professional society, we are committed to providing a safe and supportive forum for the communication of world-class science. The EMGS Diversity and Inclusion committee sends a special welcome to members of the LGBT community.  Please reach out to any member of the EMGS Diversity and Inclusion Committee with your comments.

Saturday, September 21, 2019

7:00 AM - 8:15 AM

Special Interest Group Meeting

Epigenomics
Room: Pan American
Special Interest Group Meeting

Applied Genetic Toxicology
Room: Statler
Committee Meeting

Membership and Professional Development/Education, Student and New Investigator Affairs
Room: New York

8:30 - 9:30 AM

Keynote Address:

Translational Research to Prevent Environmental Threats to Children’s Developing Brains

Frederica Perera, Columbia University, New York City, NY USA

Room: Presidential Ballroom

10:00 AM - 12:00 PM

Early Life Vulnerabilities to Environmental Exposures: From Molecular Mechanisms to Regulatory Efforts

Co-chairs: Nina Holland, University of California, Berkeley, CA, USA, Andres Cardena, Harvard University, Cambridge, MA, USA

Room: Presidential Ballroom


10:00-10:25 AM   
Chromatin Vulnerabilities of Early Germ Cells
Victor Corces, Emory University

10:25-10:50 AM   
DNA Methylation and Health Outcomes in Birth Cohorts

Nina Holland, University of California, Berkeley, United States

10:50-11:15 AM  
Prenatal Environmental Exposures, Epigenetics and Child Neurodevelopment

Andres Cardenas, Harvard University

11:15-11:35 PM
piRNA Expression in the Soma and its Potential Association with Perinatal Lead Exposure
Bamberandage Pinithi Perera, University of Michigan

11:35-12:00 PM   
Research and Regulatory Implications of Germline, Fetal, and Early Life Vulnerabilities to Drugs and Chemicals
Jill Escher, Escher Fund for Autism

 

Weeding out DNA Damage in a Garden of Six Billion Bases: Advances in Understanding Lesion Detection

Co-Chairs: Stephanie L. Smith-Roe, National Toxicology Program/NIEHS, Research Triangle Park, NC, USA, Bennett Van Houten, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA

Room: South American AB


10:00-10:30 AM
Teaching an Old Dog New Tricks: Novel Role of UV-DDB in Base Excision Repair
Bennett Van Houten, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

10:30-11:00 AM
FeS-Containing DNA Repair Proteins: Chewing their Way through the Genome
Sheila S. David, University of California, Davis, CA, USA

11:00-11:30 AM
Monkey Business: How to Move in the DNA Jungle 
Karolin Luger, University of Colorado Boulder, and Howard Hughes Medical Institute

11:30-11:45 AM
Identifying DNA and Enzyme Structural Features Necessary for MutY Glycosylase Detection of Specific DNA Damage Sites Using Single Molecule Fluorescence Microscopy
Andrea Lea, University of Vermont, Burlington, Vermont

11:45-12:00 PM
Characterizing the APE1 DNA Intercalating Loop During DNA Sculpting
Nicole Hoitsma, University of Kansas Medical Center, Kansas City, KS
 

Platform 2: DNA Damage & Environmental Disease Risk

Co-Chairs: Rosalie Elespuru, US Food and Drug Administration; and Caren Weinhouse, Oregon Health & Science University

Room: Federal AB


10:00-10:15 AM
Mutational Imprints of Cobalt Exposure: A Genome-Scale Multi-system
 Approach
Jiri Zavadil, International Agency for Research on Cancer, Lyon, France

10:15-10:30 AM
Bioflavonoids induce DNA Double-Strand Breaks by Topoisomerase II-dependent and –independent Mechanisms
Donna Alice Goodenow, University of North Carolina at Charlotte

10:30-10:45 AM
Mutational Signature Analysis for Molecular Cancer Epidemiology: The Example of Aristolochic Acid
Steven George Rozen, Duke-NUS Medical School

10:45-11:00 AM
A Roadmap from Hotspot Cancer Driver Mutation Quantification to Cancer Prediction
Barbara Parsons, US Food and Drug Administration

11:00-11:15 AM
Evaluating the Genotoxicity of Mixtures of Pyrrolizidine Alkaloids with Differing Relative Potencies Demonstrates Additivity of Effects
Ashley Allemang, The Procter & Gamble Company

11:15-11:30 AM
How Low Can You Go? An Analysis of Lowest Effective Dose in the Ames Test
Grace Kocks, Lhasa Limited

11:30-11:45 AM
The Mutation Signatures Specific To DNA Alkylating Agents In Yeast And Cancers
Natalie Saini, National Institute of Environmental Health Sciences

11:45-12:00 PM
Modeling Aging and Degenerative Disease in DNA Repair-Deficient Drosophila
Elyse Bolterstein, Northeastern Illinois University

12:00 - 1:15 PM

Women in EMGS Luncheon

Endometrial Cancer: Genomics and Genetics
Daphne Bell, National Human Genome Research Institute/NIH

Room: Senate

1:30 - 3:30 PM

Oceans and Environmental Health

Chair: Rob Sobol, University of South Alabama Mitchell Cancer Institute, Mobile, AL, USA

Room: Presidential Ballroom


1:30-2:00 PM
Lake Erie Center for Fresh Waters and Human Health: Using Advanced ‘Omics Techniques and Novel Technologies to Investigate Environmental Drivers of Toxic Cyanobacterial Blooms, Discover Novel Compounds, and Improve Cyanotoxin Monitoring
Timothy Davis, Bowling Green State University, Bowling Green, OH, USA

2:00-2:15 PM
TBA

2:15-2:45 PM
Urbanization and Climate Change: A Recipe for Disaster for Ecosystem and Human Health
Geoffrey Scott, Arnold School of Public Health

2:45-3:00 PM
TBA

3:00-3:30 PM
The Greater Caribbean Center for Ciguatera Research – Examining the Impact of Climate Change on Ciguatera and its Toxic Metabolites Through the Food Web and the Mechanisms of Human Cell Genotoxicity
Robert Sobol, University of South Alabama Mitchell Cancer Institute, Mobile, AL, USA

Mechanisms of Genomic Instability: from DNA Structure to Human Disease and Aging

Co-Chairs: Phil Hanawalt, Stanford University, Stanford, CA, USA, Bevin Engelward, Massachusetts Institute of Technology, Cambridge, MA, USA

Room: South American AB


1:30-1:54 PM                     
Duplex Sequencing Mimics Nature’s Approach for Accurate DNA Replication: Extensive 
Subclonal Mutations in Human Cancers
Lawrence A. Loeb, University of Washington, Seattle, WA, USA

1:54-2:18 PM
Breaking Bad: Aberrant DNA Repair and Repeat Expansion in Fragile X Syndrome
Karen Usdin,The National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA

2:18-2:42 PM

Topoisomerase II-induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity
André Nussenzweig, Laboratory of Genome Integrity, National Cancer Institute, Bethesda, MD, USA

2:42-3:06 PM
Oxidative DNA Damage Can Be Mutagenic or Epigenetic
Cynthia Burrows, University of Utah, Salt Lake City, UT, USA

3:06-3:30 PM
How Cells Regulate Mutagenesis and Their Ability to Evolve
Susan Rosenberg, Baylor College of Medicine, Houston, TX, USA


Low-Dose Mutagenic Responses: Biology, Assumptions and Challenges in Protecting Human Health

Co-Chairs: Catherine Gibbons, US EPA, Washington, DC, USA, David Eastmond, University of California, CA, USA

Room: Federal AB


1:30-2:00 PM
Dose-Response Lessons from Ultra-Low Dose Cancer Studies of the Mutagenic Carcinogens Dibenzo[d,e,f,p] Chrysene and Aflatoxin B1 in Trout
David Williams, Oregon State University

2:00-2:15 PM
Impact of Radiation Dose Rate on Mammary Gland Development and Immune System
Janice M. Pluth, University of Nevada, Las Vegas, NV

2:15-2:45 PM
Genotoxicity Mechanisms Driving Non-linear Dose Responses- Highlights From a GUM Review and a Food Impurity Example
Stefan Pfuhler, Procter and Gamble

2:45-3:00 PM
Preferential Tissue Dysregulation of the Mouse Epigenome by Low Dose 5-aza-2'deoxycytidine Exposure
Mathia L Colwell, University of Minnesota

3:00-3:30 PM
Factors Influencing Mutagenic Mode of Action Determinations and their Role in Low Dose Extrapolations of Carcinogenic Risk
David Eastmond, University of California, Riverside

3:30 - 4:30 PM

Alexander Hollaender Award Lecture:

Epigenetics in Human Health and Disease

Randy Jirtle, North Carolina State University, Raleigh, North Carolina, USA

Room: Presidential Ballroom

4:30 - 5:00 PM

Flash Talks

Room: Federal AB

A Stand-Alone Software Tool with a Graphical User Interface Employing Machine-Learning and Digital Signal Processing (ML-DSP) for Accurate GenomeWide Classification of Human Mitochondrial Diseases and Cancer Types.
Gurjit Randhawa, University of Western Ontario

Robust Experimental and Computational Methods for In-Depth Characterization of Mutational Signatures.
Steven G. Rozen, Duke University

The Vulnerability of the Germline: Epigenetic Responsibility.
Anne Le Goff, UCLA

The Lagging Strand is More Accurate but Lives Dangerously.
Roel Schaaper, NIEHS

Considerations in Addressing Irrelevant or False Positive Genotoxicity Results During Drug Development: Regulatory Consultant's Perspective.
Gopala Krishna, PAREXEL International

Experimental Models Elucidate the Relationship Between Genetic and Epigenetic Alterations During Carcinogen-mediated Cell Transformation.
Michael Korenjak, International Agency for Res. on Cancer

Effect of Aging on the Repeated Dose Liver Micronucleus Assay.
Shuichi Hamada, LSI Medience Corporation

Evaluating Non-Covalent DNA-Binders in the MultiFlow Assay.
Dan Roberts, Charles River Laboratories

Characterizing the Role of TDP1 During Development in Drosophila Melanogaster.
Vada Becker, Northeastern Illinois University

The Role of Werner Protein in Responding to Oxidative Stress in Drosophila Relanogaster
Derek Epiney, Northeastern Illinois University

Variation in Signatures of Cadmium-induced Mitochondrial DNA Mutations Reveal Evolutionary Effects of Pollution.
Tess Leuthner, Duke University

DNA Methylation Patterns in Fundulus heteroclitus Exposed to Power Plant Thermal Effluent.
Melissa Drown, University of Minnesota

5:00 - 7:00 PM

Poster Session 2: Even numbers

Room: Congressional

7:30 - 9:30 PM

Come celebrate EMGS’ 50th Anniversary with a 
CHAMPAGNE TOAST AT THE NATIONAL PRESS CLUB

Saturday, September 21, 2019

7:30 to 9:30 pm

This special event is free to all annual meeting attendees.

Music, Camaraderie, Celebration, Hor d’oeuvres and Champagne, and beautiful views of The White House, Washington Monument and historic Willard Hotel.

National Press Club
529 14th Street, NW, 13th Floor
Washington, DC 20045

How do I get from the Capital Hilton to the National Press Club?

The best entrance is on 14th Street, just off F Street, which is the National Press Building. The Press Club is on the 13th Floor. Once you get off the elevators on the 13th Floor, go through the security turnstiles and a receptionist will greet you. She or he will tell you where the First Amendment and Holeman Lounge rooms are.  (The rooms are very close to the reception area.) 

The National Press Club is .7 miles from the Capital Hilton to the National Press Club.

How do I get to the National Press Club from other places?

https://www.press.org/institute/about/visitor-information

What is the best entrance for someone with special needs?

The best entrance is at 14th and F Streets.