Environmental Mutagenesis & Genomics Society

50th Annual Meeting, Washington DC

September 19-23, 2019 - Capital Hilton Washington DC

Environmental Mutagenesis and Genomics: The Next Fifty Years

Special Symposium

 Important Dates


3/4/19-Registration is now Open
7/27/19-Early Bird Registration Ends
8/19/19-Advanced Registration Ends


2/22/19-Abstract Submission is now Open
5/15/19-Abstract Submission Deadline
8/29/19-Late Abstracts Deadline

Travel Awards

Travel Award Form Available
5/15/19-Travel Award Deadline

Hotel Information

2/27/19-Reservations Open
8/21/19-Reservation Deadline

Young Scientist Award

EMGS Welcomes You

The EMGS welcomes members and attendees from across the US and around the world. Our diversity is essential to our success, and as your national professional society, we are committed to providing a safe and supportive forum for the communication of world-class science. The EMGS Diversity and Inclusion committee sends a special welcome to members of the LGBT community.  Please reach out to any member of the EMGS Diversity and Inclusion Committee with your comments.

EMGS Special Symposium

Genome Maintenance Systems in Cancer Etiology and Therapy: A Tribute to Paul Modrich

September 18-19, 2019

Co-Chairs: Guo-Min Li, Robert W. Sobol, Joann Sweasy, and Karen Vasquez
Organizing Committee: Farid Kadyrov, Bill Jack, Robert Lahue, Guo-Min Li, A-Lien Lu-Chang, Robert W. Sobol, Michael Su, Joann Sweasy, Karen Vasquez, Leroy Worth

The goal of this EMGS Special Symposium is to celebrate Dr. Paul Modrich’s career-long scientific contributions as a leader of the DNA repair field. The focus of the Symposium is to bring together scientists working at the cutting edge of current efforts to elucidate the molecular mechanisms of genome-maintenance systems and their roles in cancer etiology and therapy that were pioneered by Dr. Modrich. A key outcome of the Symposium will be to stimulate discussions and to further cross-fertilize ideas at the forefront of the field. In addition to invited talks and interactive poster sessions, the program will also include short talks and “poster flash” platform presentations, as a key mechanism to ensure ample attention to the contributions and participation of students, postdoctoral fellows and other early career scientists, and to seek out and actively encourage their attendance at the symposium. We invite scientists in the field to join the exciting symposium.

Register Now

*Registration for the Annual Meeting is a separate form*

Submit an Abstract

List of Speakers

Meeting Highlights

  • Acquire knowledge of DNA repair pathways in cancer development and treatment.
  • Prepare a poster and highlight your research.
  • Network with national and international seasoned researchers.
  • Celebrate Dr. Paul Modrich’s career-long scientific contributions as a leader of the DNA repair field.

September 18th, 2019

1:30 PM

Welcome/Opening Remarks

Robert W. Sobol, University of South Alabama, Past-President of EMGS

1:35-3:15 PM

Mechanisms of Genome Maintenance Systems I

Chair: Robert W. Sobol, University of South Alabama Mitchell Cancer Institute, Mobile, AL

1:35 PM
The Effects of Mismatch Repair on Nuclear DNA Replication Fidelity in Budding Yeast
Thomas Kunkel, NIEHS, USA

1:55 PM
The Mismatch Repair Interactome
Joseph Jiricny, University of Zurich, Zurich, Switzerland

2:15 PM
MutSbeta and Triplet Repeat Expansions
Robert Lahue, National University of Ireland, Ireland

2:35 PM
Regulation of Mismatch Repair
Farid Kadyrov, Southern Illinois University, USA

2:55 PM
Integrative Single-Molecule Studies of DNA Mismatch Initiation
Dorothy Erie, University of North Carolina, USA 

3:15 - 3:35 PM

Coffee Break (With Posters)

3:35 - 4:55 PM

Mechanisms of Genome Maintenance Systems II

Chair: Robert Lahue, National University of Ireland Galway, Ireland

3:35 PM
Chromosome Damage Repair via the BRCA1/2 Axis 
Patrick Sung, University of Texas Health Science Center at San Antonio, USA

3:55 PM
The MRN Complex and Maintenance of Genomic Stability 
Tanya Paull, University of Texas Austin, USA

4:15 PM
Title TBA
Priscilla Cooper, Lawrence Berkley National Laboratory, USA

4:35 PM
Regulation of Base Excision Repair Complex Assembly and Disassembly in Human Cells 
Robert W. Sobol, University of South Alabama Mitchell Cancer Institute, Mobile, AL, USA 

4:55-5:35 PM

Short Talks (10 minutes each)

5:35-6:25 PM

Poster Flash (5 mintues each)

6:30 PM


September 19th, 2019

8:30 - 10:10 AM

Mechanisms of Genome Maintenance Systems III

Chair: Karen Vasquez, University of Texas Austin

8:30 AM
SMX and GEN1: Structure-Selective Nucleases Essential for the Resolution of Replication and Recombination Intermediates
Stephen West, The Francis Crick Institute, UK

8:50 AM
Maintenance of Genome Integrity: A Few Mechanisms Discovered Recently in Eukaryotic Cells
Daochun Kong, Peking University, China

9:10 AM
Mismatch Repair and Autoimmunity
Joann Sweasy, Yale University, USA

9:30 AM
The Role of Checkpoint Clamp in DNA Repair
A-Lien Lu-Chang, University of Maryland Baltimore, USA

9:50-10:10 AM

Short Talks (10 minutes each)

10:10-10:30 AM

Coffee Break

10:30 AM - 11:50 AM

Therapeutic Approaches

Chair: Joann Sweasy, Yale University

10:30 AM
Improving Chemotherapy by Inhibiting Mutagenic Translesion DNA Synthesis
Graham Walker, MIT, Cambridge, USA

10:50 AM
DNA Structure-Induced Genetic Instability: Mechanisms and Therapeutic Potential
Karen Vasquez, University of Texas Austin, USA

11:10 AM
Mismatch Repair: Mechanisms and Potential Roles in Cancer Prevention and Therapy 
Guo-Min Li, UT Southwestern, USA

11:30 AM
Towards Therapeutically Modulating Disease-Associated Repeat Instability 
Christopher E. Pearson, The Hospital for Sick Children

11:50 - 2:00 PM

Lunch and Poster Session

2:00 - 3:20 PM

Structure Insights and Drug Design

Chair: Leroy Worth, NIEHS

2:00 PM
Structures and Operating Principles of the DNA Replisome
Wei Yang, NIH/NIDDK, Bethesda, USA

2:20 PM
Understanding DNA Polymerase Mistakes at the Atomic Level 
Samuel Wilson, NIEHS, USA

2:40 PM
Visualizing Transient States in Mismatch Repair Initiation 
Titia Sixma, Netherlands Cancer Institute, Netherlands

3:00 PM
Inner Workings of DNA Mismatch Repair Machines
Lorena Beese, Duke University, USA

3:20 - 3:40 PM

Short Talks (10 minutes each)

3:40 - 4:00 PM

Coffee Break

4:00 - 5:00 PM

Reflections on 50 Years in Science

Chair: Guo-Min Li, UT Southwestern

4:00 PM
Genomic Maintenance Comes of Age 
Phil Hanawalt, Stanford University, USA

4:15 PM
Almost 50 Years of Base Excision Repair
Susan Wallace, University of Vermont, USA

4:30 PM
Paul Modrich - A Biographical Sketch 
Errol Friedberg, UT Southwestern, USA

4:45 PM
A Few of My Favorite Things 
Paul Modrich, Duke University, USA

5:00 PM

Closing Remarks

Guo-Min Li, UT Southwestern, USA