Environmental Mutagenesis & Genomics Society

50th Annual Meeting, Washington DC

September 19-23, 2019 - Capital Hilton Washington DC

Environmental Mutagenesis and Genomics: The Next Fifty Years

Special Symposium
Registration

 Important Dates

Registration

3/4/19-Registration is now Open
7/27/19-Early Bird Registration Ends
8/19/19-Advanced Registration Ends

Abstracts

2/22/19-Abstract Submission is now Open
5/15/19-Abstract Submission Deadline
8/29/19-Late Abstracts Deadline

Travel Awards

Travel Award Form Available
5/15/19-Travel Award Deadline

Hotel Information

2/27/19-Reservations Open
8/21/19-Reservation Deadline

Young Scientist Award


EMGS Welcomes You

The EMGS welcomes members and attendees from across the US and around the world. Our diversity is essential to our success, and as your national professional society, we are committed to providing a safe and supportive forum for the communication of world-class science. The EMGS Diversity and Inclusion committee sends a special welcome to members of the LGBT community.  Please reach out to any member of the EMGS Diversity and Inclusion Committee with your comments.

EMGS Special Symposium

Genome Maintenance Systems in Cancer Etiology and Therapy: A Tribute to Paul Modrich

September 18-19, 2019

Co-Chairs: Guo-Min Li, Robert W. Sobol, Joann Sweasy, and Karen Vasquez
Organizing Committee: Farid Kadyrov, Bill Jack, Robert Lahue, Guo-Min Li, A-Lien Lu-Chang, Robert W. Sobol, Michael Su, Joann Sweasy, Karen Vasquez, Leroy Worth


The goal of this EMGS Special Symposium is to celebrate Dr. Paul Modrich’s career-long scientific contributions as a leader of the DNA repair field. The focus of the Symposium is to bring together scientists working at the cutting edge of current efforts to elucidate the molecular mechanisms of genome-maintenance systems and their roles in cancer etiology and therapy that were pioneered by Dr. Modrich. A key outcome of the Symposium will be to stimulate discussions and to further cross-fertilize ideas at the forefront of the field. In addition to invited talks and interactive poster sessions, the program will also include short talks and “poster flash” platform presentations, as a key mechanism to ensure ample attention to the contributions and participation of students, postdoctoral fellows and other early career scientists, and to seek out and actively encourage their attendance at the symposium. We invite scientists in the field to join the exciting symposium.

Register Now

*Registration for the Annual Meeting is a separate form*

Submit an Abstract


List of Speakers

Meeting Highlights

  • Acquire knowledge of DNA repair pathways in cancer development and treatment.
  • Prepare a poster and highlight your research.
  • Network with national and international seasoned researchers.
  • Celebrate Dr. Paul Modrich’s career-long scientific contributions as a leader of the DNA repair field.

September 18th, 2019

1:30 PM

Welcome/Opening Remarks

Robert W. Sobol, University of South Alabama, Past-President of EMGS

1:35-3:15 PM

Mechanisms of Genome Maintenance Systems I

Chair: Robert W. Sobol, University of South Alabama Mitchell Cancer Institute, Mobile, AL

Room: Federal AB


1:35 PM
The Effects of Mismatch Repair on Nuclear DNA Replication Fidelity in Budding Yeast
Thomas Kunkel, NIEHS, USA

1:55 PM
MutSbeta and Triplet Repeat Expansions
Robert Lahue, National University of Ireland, Ireland

2:15 PM
Integrative Single-Molecule Studies of DNA Mismatch Initiation
Dorothy Erie, University of North Carolina, USA 

2:35 PM
Regulation of Mismatch Repair
Farid Kadyrov, Southern Illinois University, USA

2:55 PM
Phosphorylated PCNA Recruits Translesion DNA Polymerases and Promotes Cancer Progression by Activating the ATM/Akt/GSK3β/Snail Signaling Pathway
Janice Ortega, UT Southwestern, USA

3:05 PM
HDAC6 Regulates the DNA Damage Response via Deacetylating MLH1
Xiaohong (Mary) Zhang, Wayne State University School of Medicine, USA

3:15 PM
The MRN Complex and Maintenance of Genomic Stability 
Tanya Paull, University of Texas Austin, USA

3:35 - 3:55 PM

Coffee Break (With Posters)
Room: South American AB

3:55 - 5:45 PM

Structure Insights and Drug Design

Chair: Leroy Worth, NIEHS

Room: Federal AB


3:55 PM
Structures and Operating Principles of the DNA Replisome
Wei Yang, NIH/NIDDK, Bethesda, USA

4:15 PM
Targeting Structural Changes to Control DNA Repair in Cancer
John Tainer, MD Anderson, USA 

4:35 PM
Visualizing Transient States in Mismatch Repair Initiation 
Titia Sixma, Netherlands Cancer Institute, Netherlands

4:55 PM
Inner Workings of DNA Mismatch Repair Machines
Lorena Beese, Duke University, USA

5:15 PM
Insight into DNA Mismatch Repair Initiation Through Monte Carlo Simulations and Functional Analysis
Joyce Lebbink, University Medical Center Rotterdam, Netherlands

5:25 PM
Biochemical and Structural Characterization of Two Variants of Uncertain Significance in the PMS2 Gene
Aishwarya Prakash, University of South Alabama, USA

5:35 PM
Visualizing REV1 Insertion at the Molecular Level
Bret Freudenthal, University of Kansas Center, USA

5:45-6:30 PM

Poster Flash (4min each)

Chair: Bill Jack, New England BioLabs, USA

Room: Federal AB


Chk1 Inhibitor is a Novel Therapeutic Agent for Melanoma
Bor-Jang Hwang, University of Maryland School of Medicine, Baltimore, MD, USA

The Mutation Signatures Specific to DNA Alkylating Agents in Yeast and Cancers
Natalie Saini, Genome Instability and Structural Biology Laboratory, NIEHS, USA

Targeted Oxidative Telomere Base Damage Induces Growth Arrest and Senescence in Normal Human Cells
Ryan Barnes, University of Pittsburgh Graduate School of Public Health and Hillman Cancer Center, USA

Structural Basis for Recognition and Excision of 5-carboxylcytosine by Thymine DNA Glycosylase
Lakshmi Swarna Mukhi Pidugu, University of Maryland School of Medicine, USA

Molecular Insight into APE1 Recession of 8-oxoGuanine
Amy Whitaker, University of Kansas Medical Center, USA

Characterizing the APE1 DNA Intercalating Loop During DNA Sculpting
Nicole Hoitsma, University of Kansas Medical Center, USA

Studying Thymine DNA Glycosylase (TDG) CpG Specificity Using 19F NMR
Blaine Dow, University of Maryland School of Medicine, USA

Error-prone DNA Synthesis by DNA Polymerase 0 Causes CAG Repeat Expansions
Kara Chan, UT Southwestern, USA

Structural Characterization of REV1 Catalysis
Tyler Weaver, University of Kansas Medical Center, USA

Genome-wide Mutagenesis Resulting from Topoisomerase 1-Processing of Unrepaired Ribonucleotides in DNA
Jessica Williams, NIEHS, USA

6:30 PM

Dinner
Room: Senate

September 19th, 2019

8:30 - 10:10 AM

Mechanisms of Genome Maintenance Systems II

Chair: Karen Vasquez, University of Texas Austin

Room: Federal AB


8:30 AM
SMX and GEN1: Structure-Selective Nucleases Essential for the Resolution of Replication and Recombination Intermediates
Stephen West, The Francis Crick Institute, UK

8:50 AM
Maintenance of Genome Integrity: A Few Mechanisms Discovered Recently in Eukaryotic Cells
Daochun Kong, Peking University, China

9:10 AM
Mismatch Repair and Autoimmunity
Joann Sweasy, Yale University, USA

9:30 AM
The Role of Checkpoint Clamp in DNA Repair
A-Lien Lu-Chang, University of Maryland Baltimore, USA

9:50 AM
Dynamic Distribution of Single Strand Binding Protein on ssDNA Revealed by Precise Footprinting-Seq at Near Nucleotide Solution
Hailin Wang, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, China

10:00 AM
Targeting Protein-DNA Interactions in the DNA Damage Response: Lead Identification and Optimization for Novel Inhibitors of Replication Protein A (RPA) and Ku
Katherine Pawelczak, NERx Biosciences Inc., and Indiana University School of Medicine, USA

10:10-10:30 AM 

Coffee Break
Room: South American AB

10:30 AM - 12:00 AM

Therapeutic Approaches

Chair: Joann Sweasy, Yale University

Room: Federal AB


10:30 AM
Improving Chemotherapy by Inhibiting Mutagenic Translesion DNA Synthesis
Graham Walker, MIT, Cambridge, USA

10:50 AM
DNA Structure-Induced Genetic Instability: Mechanisms and Therapeutic Potential
Karen Vasquez, University of Texas Austin, USA

11:10 AM
Novel Mechanism Underlying Mismatch Repair Deficiency-Triggered Immunotherapy 
Guo-Min Li, UT Southwestern, USA

11:30 AM
Towards Therapeutically Modulating Disease-Associated Repeat Instability 
Christopher E. Pearson, The Hospital for Sick Children

11:50 AM
FancA Promotes DNA Double Strand Break Repair by Catalyzing Single-Strand Annealing and Strand Exchange and Serves as a Potential Target for Cancer Treatment
Yanbin Zhang, University of Miami School of Medicine, USA

12:00 - 2:00 PM

Lunch and Poster Session
Room: Senate

2:00 - 3:40 PM

Mechanisms of Genome Maintenance Systems III

Chair: Robert Lahue, National University of Ireland Galway, Ireland

Room: Federal AB


2:00 PM
Chromosome Damage Repair via the BRCA 1/2 Axis
Patrick Sung, University of Texas Health Science Center at San Antonio, USA

2:20 PM
Mutational Hotspots Resulting from Mutagens and Repair Deficient Strains in the rpoB gene of Escherichia coli: Perspective on Mutational Hotspots
Jeffery Miller, University of California, Los Angeles, USA

2:30 PM
Uracils in DNA: Causes and Consequences
Ashok Bhagwat, Department of Chemistry, Wayne State University, USA

2:40 PM
DNA Repair Pathway Crosstalk in Maintenance of Genome Stability
Priscilla Cooper, Lawrence Berkley National Laboratory, USA

3:00 PM
Regulation of Base Excision Repair Complex Assembly and Disassembly in Human Cells
Robert Sobol, University of South Alabama Mitchell Cancer Institute, Mobile, AL, USA

3:20 PM
The Laggin Strand is More Accurate but Lives Dangerously
Roel Schaaper, NIEHS, USA

3:30 PM
How to Make Biology Easier for the Future of Science

Eric Wang, GenScript USA Inc. Piscataway, NJ, USA

3:40 - 4:00 PM

Coffee Break
South American AB

4:00 - 5:00 PM

Reflections on 50 Years in Science

Chair: Guo-Min Li, UT Southwestern

Room: Federal AB


4:00 PM
Genomic Maintenance Comes of Age 
Phil Hanawalt, Stanford University, USA

4:15 PM
Almost 50 Years of Base Excision Repair
Susan Wallace, University of Vermont, USA

4:30 PM
Paul Modrich - A Biographical Sketch 
Errol Friedberg, UT Southwestern, USA

4:45 PM
A Few of My Favorite Things 
Paul Modrich, Duke University, USA

5:00 PM

Closing Remarks

Guo-Min Li, UT Southwestern, USA