Environmental Mutagenesis & Genomics Society

50th Annual Meeting, Washington DC

September 19-23, 2019 - Capital Hilton Washington DC

Environmental Mutagenesis and Genomics: The Next Fifty Years

Special Symposium
Registration

 Important Dates

Registration

3/4/19-Registration is now Open
7/27/19-Early Bird Registration Ends
8/19/19-Advanced Registration Ends

Abstracts

2/22/19-Abstract Submission is now Open
5/15/19-Abstract Submission Deadline
8/29/19-Late Abstracts Deadline

Travel Awards

Travel Award Form Available
5/15/19-Travel Award Deadline

Hotel Information

2/27/19-Reservations Open
8/21/19-Reservation Deadline

Young Scientist Award


EMGS Welcomes You

The EMGS welcomes members and attendees from across the US and around the world. Our diversity is essential to our success, and as your national professional society, we are committed to providing a safe and supportive forum for the communication of world-class science. The EMGS Diversity and Inclusion committee sends a special welcome to members of the LGBT community.  Please reach out to any member of the EMGS Diversity and Inclusion Committee with your comments.

Sunday, September 22, 2019

7:00 AM - 8:00 AM

Special Interest Group Meeting

Risk Assessment
Special Interest Group Meeting

Transgenics & In Vivo Metagenesis
Committee Meeting

Annual Meeting Publicity

8:30 - 9:30 AM

Keynote:

Science on the International Space Station: Preparing NASA for the Next Fifty Years

Sarah Wallace, National Aeronautics and Space Administration (NASA), Houston, TX, USA

10:00 AM - 12:00 PM

Circadian Clock Disruption and its Impact on Genomic Instability and Environmental Carcinogenesis

Co-Chairs: Shobhan Gaddameedhi, Washington State University, Spokane, WA, USA, Michael G. Kemp, Wright State University, Dayton, OH, USA


10:00 AM - 10:30 AM
The Circadian Clock Biology in General and the Skin Circadian Rhythms in Application to Chrono Medicine
John Hogenesch, University of Cincinnati, OH, USA

10:30 AM - 11:00 AM
Circadian Clock Regulation of Genomic Stability and its Impact on Metabolism
Katja Lamia,Scripps Research Institute, San Diego, CA, USA

11:00 AM - 11:30 AM
Dynamic Interaction Between the Clock Proteins and DNA Damage Response Signaling
Carla Finkielstein, Virginia Tech Institute, Blacksburg, VA, USA

11:30 AM - 12:00 PM
Solar UV-B Induced Erythema and Environmental Carcinogenesis: The Circadian Clock is Ticking
Shobhan Gaddameedhi, Washington State University, Spokane, WA, USA

Novel Strategies for High Throughput Assessment of Genetic Toxicity

Co-Chairs: Rosalie Elespuru, US FDA and Paul White, Health Canada


10:00 - 10:24 AM
High Throughput Microarray Technology for Genotoxicity and Cytotoxicity
Bevin Engleward, Massachusetts Institute of Technology, Cambridge, MA

10:24 - 10:48 AM
MultiFlow - A High Information Content Assay that Provides Genotoxic Mode of Action Predictions and Insights into Potency and Molecular Targets
Stephen Dertinger, Litron Laboratories

10:48 - 11:12 AM
Assessment of Genotoxicity Potential Using High Throughput Screening Approaches: The Tox21 Experience
Kristine Witt, NTP

11:12 - 11:36 AM
ToxTracker assay for high-throughput screening of genetic toxicity and mode of action
Giel Hendricks, Toxys, Netherlands

11:36 - 12:00 PM
Genome-wide and Targeted CRISPR Functional Approaches in Toxicology
Christopher Vulpe, University of Florida

Platform: Epigenomics and Genomics


10:00-10:15 AM
A Genomic Atlas of Systemic Interindividual Epigenetic Variation in Humans
Chathura Gunasekara, Baylor College of Medicine

10:15-10:30 AM
Regulation of the Epigenetic Response to Oxidative Damage
Heather O'Hagan, Indiana University School of Medicine

10:30-10:45 AM
Smoking and Mutations in Sperm DNA
Jonatan Axelsson, Lund University

10:45-11:00 AM
RING1A Ubiquitinates Histone H2A at Sites of Platinum-Induced Damage
Heather O'Hagan, Indiana University School of Medicine

11:00-11:15 AM
Genetic and Epigenetic Effects in a Population of Underground Miners with Coal Workers Pneumoconiosis
Diana Maria Narvaez, Human Genetics Laboratory, Universidad de los Andes

11:15-11:30 AM
A Genomic Atlas of Systemic Interindividual Epigenetic Variation in Humans
Chathura Gunasekara, Baylor College of Medicine

11:30-11:45 AM
Ultra-sensitive Duplex Sequencing Reveals Influence of Exogenous Stressors on Mitochondrial DNA Mutagenesis
Tess Leuthner, Duke University

11:45-12:00 PM
Mouse liver miRNA expression profile as a molecular marker of low dose rates gamma radiation, in two mouse strains
Ann-Karin Olsen, Norwegian Institute of Public Health

12:00 - 1:15 PM

Special Interest Group Meeting

Genomics

Special Interest Group Meeting

Environmental Genetic Toxicology, Molecular Epidemiology, and Risk Assessment

Committee Meeting

Finance and Fundraising

1:30 - 3:30 PM

Application of 3D Organoid Models to investigation of Carcinogenesis, Drug Development and Genetic Toxicology

Chair: Jeffrey Bemis, Litron Laboratories


1:30-2:00 PM
Bioprinting 3D Vascularized Tissue Models
Alisa Morss Clyne, Drexel University

2:00-2:30 PM
Design and Implementation of a 3D Organotypic Model of the Human Mesothelium for High-Throughput Screening
Hillary Kenny, University of Chicago, IL, USA

2:30-3:00 PM
Development of Advanced In Vitro Lung and Prostate Cancer Models for Hazard Assessment
Steven Evans, Swansea University

3:00-3:15 PM
From Abstracts

3:15-3:30 PM
From Abstracts

Quantitative Analysis of Genetic Toxicity Dose-Response Data for Risk Assessment and Regulatory Decision-Making

Co-Chairs: Kerry Dearfield, US DA/ETA (retired), Washington DC, USA, Paul White, Health Canada;
New Investigator Co-Chair: Alexandra Long, Health Canada


1:30- 1:40 PM
Introductory remarks
Alexandra Long, Health Canada, Ottawa, Canada

1:40-2:00 PM
From Hazard Identification to Risk Assessment: A Paradigm Shift in Genetic Toxicology
James MacGregor, Toxicology Consulting Services, Bonita Springs, FL, USA

2:00-2:45 PM
Interpretation of Genetic Toxicity Dose Response Data and Use of Point-of-Departure Metrics for Risk Assessment and Regulatory Decision-making
Wout Slob, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

2:45-3:00 PM
Adjustment Factors for Regulatory Interpretation of Genetic Toxicity Point-of-departure Metrics
Paul White, Health Canada, Ottawa, Canada.

3:00-3:15 PM
Case Studies Related to Quantitative Interpretation of Genetic Toxicity Dose-response Data
Alexandra Long, Health Canada

3:15-3:30 PM
Characterization and Management of Genotoxic Risk
Kerry Dearfield, Burke, VA, USA


 


Platform: DNA Damage Response II


1:30-1:45 PM
Structural and Biochemical Analysis of the 3ʹ→5ʹ Exonuclease Apn2 of Saccharomyces Cerevisiae
Jessica Wojtaszek, NIEHS

1:45-2:00 PM
G-quadruplex induced genomic instability in the absence of functional topoisomerase 1
Alexandra Berroyer, University of Texas Health Science Center

2:00-2:15 PM
A novel regulation mechanism of OGG1 under oxidative stress
Khadijeh Alnajjar, Yale University School of Medicine

2:15-2:30 PM
Single Molecule Analysis Reveals Monomeric XPA Bends DNA and Undergoes Episodic Linear Diffusion During Damage Search
Emily Beckwitt, University of Pittsburgh School of Medicine

2:30-2:45 PM
Targeted Oxidative Telomere Base Damage Induces Growth Arrest and Senescence in Normal Human Cells
Ryan Barnes, University of Pittsburgh

2:45-3:00 PM

3:00-3:15 PM
Deciphering the roles of PARP1/ARTD1 in the preservation of telomere integrity
Elise Fouquerel, Thomas Jefferson University and Sydney Kimmel Medical College

3:15-3:30 PM
Investigating the impact of oxidized and therapeutic dNTPs on telomerase activity
Samantha Sanford, University of Pittsburgh

3:30 - 4:30 PM

Young Investigator Award Lecture

4:30 - 5:45 PM

Business Meeting

5:45 - 6:45 PM

Emeritus/Retiree Interest Group Mixer

7:00 - 11:00 PM

Banquet