Circadian Clock Disruption and its Impact on Genomic Instability and Environmental Carcinogenesis

Co-Chairs: Shobhan Gaddameedhi, Washington State University, Spokane, WA, USA, Michael G. Kemp, Wright State University, Dayton, OH, USA

Room: Presidential Ballroom

10:00 AM - 10:30 AM
Implementing Circadian Medicine: from Skin Biomarkers to New Therapies
John Hogenesch, University of Cincinnati, OH, USA

10:30 AM - 11:00 AM
Cryptochromes Integrate Circadian Rhythms with Metabolism and Genome Protection
Katja Lamia,Scripps Research Institute, San Diego, CA, USA

11:00 AM - 11:30 AM
Dynamic Interaction Between the Clock Proteins and DNA Damage Response Signaling
Carla Finkielstein, Virginia Tech Institute, Blacksburg, VA, USA

11:30 AM - 12:00 PM
Solar UV-B Induced Erythema and Environmental Carcinogenesis: The Circadian Clock is Ticking
Shobhan Gaddameedhi, Washington State University, Spokane, WA, USA

Novel Strategies for High Throughput Assessment of Genetic Toxicity

Co-Chairs: Rosalie Elespuru, US Food and Drug Administration and Paul White, Health Canada

Room: South American AB

10:00 - 10:24 AM
High Throughput Microarray Technology for Genotoxicity and Cytotoxicity
Bevin Engleward, Massachusetts Institute of Technology, Cambridge, MA

10:24 - 10:48 AM
MultiFlow - A High Information Content Assay that Provides Genotoxic Mode of Action Predictions and Insights into Potency and Molecular Targets
Stephen Dertinger, Litron Laboratories

10:48 - 11:12 AM
Assessment of Genotoxicity Potential Using High Throughput Screening Approaches: The Tox21 Experience
Kristine Witt, NTP

11:12 - 11:36 AM
ToxTracker Assay for High-Throughput Screening of Genetic Toxicity and Mode of Action
Giel Hendricks, Toxys, Netherlands

11:36 - 12:00 PM
Genome-wide and Targeted CRISPR Functional Approaches in Toxicology
Christopher Vulpe, University of Florida

Platform 3: Epigenomics and Genomics

Co-Chairs: Patrick Allard, University of California, Los Angeles; Chris Faulk, University of Minnesota; and Isabelle Miousse, University of Arkansas for Medical Sciences

Room: Federal AB

10:00-10:15 AM
A Genomic Atlas of Systemic Interindividual Epigenetic Variation in Humans
Chathura Gunasekara, Baylor College of Medicine

10:15-10:30 AM
Regulation of the Epigenetic Response to Oxidative Damage
Heather O'Hagan, Indiana University School of Medicine

10:30-10:45 AM
Smoking and Mutations in Sperm DNA
Jonatan Axelsson, Lund University

10:45-11:00 AM
RING1A Ubiquitinates Histone H2A at Sites of Platinum-Induced Damage
Heather O'Hagan, Indiana University School of Medicine

11:00-11:15 AM
Genetic and Epigenetic Effects in a Population of Underground Miners with Coal Workers Pneumoconiosis
Diana Maria Narvaez, Human Genetics Laboratory, Universidad de los Andes

11:15-11:30 AM
Genome-wide Analysis of Cadmium-induced Germline Mutations over 1,123 Generations
Nathan Keith, Indiana University

11:30-11:45 AM
Ultra-sensitive Duplex Sequencing Reveals Influence of Exogenous Stressors on Mitochondrial DNA Mutagenesis
Tess Leuthner, Duke University

11:45-12:00 PM
Mouse liver miRNA expression profile as a molecular marker of low dose rates gamma radiation, in two mouse strains
Ann-Karin Olsen, Norwegian Institute of Public Health

Application of 3D Organoid Models to investigation of Carcinogenesis, Drug Development and Genetic Toxicology

Chair: Jeffrey Bemis, Litron Laboratories

Room: Presidential Ballroom

1:30-2:00 PM
Bioprinting 3D Vascularized Tissue Models
Alisa Morss Clyne, University of Maryland

2:00-2:30 PM
Design and Implementation of a 3D Organotypic Model of the Human Mesothelium for High-Throughput Screening
Hillary Kenny, University of Chicago

2:30-3:00 PM
Development of Advanced In Vitro Lung and Prostate Cancer Models for Hazard Assessment
Steven Evans, Swansea University

3:00-3:15 PM
Validation of a Study Design for the Evaluation of the Genotoxic Potential of Cosmetic Ingredients Using 3D Human Skin Tissue Model as a Test System
Shambhu Roy, MilliporeSigma

3:15-3:30 PM
Integrating Respiratory Toxicity and Genotoxicity Endpoints in an in Vitro Model of Human Origin for Assessing Hazard to Styrene Exposure
Yiying Wang, National Center for Toxicological Research

Quantitative Analysis of Genetic Toxicity Dose-Response Data for Risk Assessment and Regulatory Decision-Making

Co-Chairs: Kerry Dearfield, USDA/EPA (retired), Paul White, Health Canada; New Investigator Co-Chair: Alexandra Long, University of Toronto

Room: South American AB

1:30- 1:40 PM
Introductory remarks
Alexandra Long, University of Toronto, Toronto, ON, Canada

1:40-2:00 PM
From Hazard Identification to Risk Assessment: A Paradigm Shift in Genetic Toxicology
James MacGregor, Toxicology Consulting Services, Bonita Springs, FL, USA

2:00-2:45 PM
Interpretation of Genetic Toxicity Dose Response Data and Use of Point-of-Departure Metrics for Risk Assessment and Regulatory Decision-making
Wout Slob, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

2:45-3:00 PM
Adjustment Factors for Regulatory Interpretation of Genetic Toxicity Point-of-departure Metrics
Paul White, Health Canada, Ottawa, Canada
Stefan Pfuhler, Procter and Gamble

3:00-3:15 PM
Case Studies Related to Quantitative Interpretation of Genetic Toxicity Dose-response Data
Alexandra Long, University of Toronto, Toronto, ON, Canada

3:15-3:30 PM
Characterization and Management of Genotoxic Risk
Kerry Dearfield, USDA/EPA (retired), Burke, VA, USA

Platform 4: DNA Damage Response II

Co-Chairs: Khadijeh Alnajjar, Yale University and Bret Freudenthal, University of Kansas Medical Center

Room: Federal AB

1:30-1:45 PM
Deciphering the Roles of PARP1/ARTD1 in the Preservation of Telomere Integrity
Elise Fouquerel, Thomas Jefferson University and Sydney Kimmel Medical College

1:45-2:00 PM
Investigating the Impact of Oxidized and Therapeutic dNTPs on Telomerase Activity
Samantha Sanford, University of Pittsburgh

2:00-2:15 PM
Targeted Oxidative Telomere Base Damage Induces Growth Arrest and Senescence in Normal Human Cells
Ryan Barnes, University of Pittsburgh

2:15-2:30 PM
G-quadruplex Induced Genomic Instability in the Absence of Functional Topoisomerase 1
Alexandra Berroyer, University of Texas Health Science Center

2:30-2:45 PM
Structural and Biochemical Analysis of the 3ʹ→5ʹ Exonuclease Apn2 of Saccharomyces Cerevisiae
Jessica Wojtaszek, National Institute of Environmental Health Sciences

2:45-3:00 PM
A Novel Regulation Mechanism of OGG1 under Oxidative Stress
Khadijeh Alnajjar, Yale University School of Medicine

3:00-3:15 PM
Single Molecule Analysis Reveals Monomeric XPA Bends DNA and Undergoes Episodic Linear Diffusion During Damage Search
Emily Beckwitt, University of Pittsburgh School of Medicine

3:15-3:30 PM
Mechanistic Insight into Oxidized Ribonucleotide Insertion by a Human DNA Polymerase
Mallory Smith, University of Kansas Medical Center