13th International Conference on Environmental Mutagens

Maintaining Genomic Health in a Changing World

53rd Annual Meeting of the EMGS

August 27 - September 1, 2022 - Ottawa Canada

 

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ICEM 2022 Sponsors

Become a Sponsor  

Diamond Level: 
Morningside
NIEHS R13 Grant
TwinStrand Biosciences


Platinum Level:
Escher Fund for Autism 

Health and Environmental Sciences Institute
Proctor & Gamble, Co. 
Health Canada 
US-FDA R13
University of Ottawa 
Carleton University
 


Gold Level:
Bristol Myers Squibb


Silver Level:
Burroughs Wellcome Fund

Elsevier
United Kingdom Environmental Mutagen Society
Gilead Sciences
National Cancer Institute (NCI)


Bronze Level:
Lhasa Limited

RIFM
Moltox, Molecular Toxicology, Inc. 
BASF
Toxys
Litron Laboratories
Instem
MultiCASE


Supporter
Mutagen-Brasil

Johnson & Johnson
University of Michigan


Contributors
European Environmental Mutagenesis and Genomics Society

Japanese Environmental Mutagen and Genome Society
Journal of Biochemistry
Illumina
Pfizer Inc.
Environmental and Molecular Mutagenesis Journal 
Bill Kaufmann
Genetic Toxicology Association
Society of Toxicology


SYMPOSIA

A total of 30 symposia are included in the main program of the meeting. Symposia are an equal balance of applied and basic science spanning the specialty areas and are summarized below:

SUNDAY, AUGUST 28, 2022

10:30 AM to 12:30 PM | Symposium 1: Advancing Mechanistic Analyses in Genetic Toxicology Using High-Content and High-Throughput Methodologies

Sponsored by: TwinStrand Logo 2022

Chairs | Alexandra Long, Health Canada, Ottawa, Canada, Dan Roberts, Charles River Laboratories, Skokie, United States, Eunnara Cho, Carleton University, Ottawa, Canada

Evaluating Cellular Responses to Toxic Compounds by High Content Screening
David Andrews, Sunnybrook Research Institute & University of Toronto, Toronto, ON, Canada

Using Deep Neural Networks for Cytogenetics, Focused on the Cytome Assay with Additional Mechanistic Markers, Assessed Using Imaging Flow Cytometry
Paul Rees, Swansea University, Swansea, United Kingdom

Update on Existing High Throughput Methods for Detecting Key Adverse Cellular Events That Lead to Genotoxicity
Steve Bryce/Bevin Engelward/Carole Yauk, Litron Laboratories/Massachusetts Institute of Technology/Health Canada

GeneTox21- An Integrated Platform for In Vitro Genetic Toxicity Assessment and Regulatory Evaluation of New and Existing Substances
Hannah Battaion, Health Canada, Ottawa, ON, Canada

High-Content Imaging and Deep Learning: Opportunities and Challenges in Toxicology
John Wills, University of Cambridge, Cambridge, United Kingdom


10:30 AM to 12:30 PM | Symposium 2: Analyses of DNA Modifications and Their Roles in Human Carcinogenesis

Chairs | Haruhiko Sugimura, Hamamatsu University School of Medicine, Hamamatsu, Japan, Silvia Balbo, University of Minnesota, Minneapolis, United States 

Human Adductomics, Challenges
Haruhiko Sugimura, Hamamatsu University School of Medicine, Hamamatsu, Japan

Untargeted DNA Adductomics
Silvia Balbo, University of Minnesota, Minneapolis, Minnesota, United States

An Experimental Tool-Box for Quantifying DNA Damage and Epigenetic Transformations
Yuval Ebenstein, Tel Aviv University, Tel Aviv, Isreal

To be determined
Guo Jingshu, University of Minnesota, Minneapolis, Minnesota, United States


10:30 AM to 12:30 PM | Symposium 3: Application of Computational Modeling and Bioinformatics in Toxicological Hazard and Risk Assessment

Chairs | Julia Rager, UNC-Chapel Hill, United States; Marc Beal, Health Canada, Canada; Scott Auerbach, NIEHS, United States

Systems biology: Systematic data integration and modeling for toxicological inference
Olivier Thierry Taboureau, Université de Paris

Application of Artificial Intelligence in Toxicology
Weida Tong, United States FDA, NCTR

Applications of Computational Techniques for Data Identification and Evidence Development in Systematic Review and Systematic Review
Daniele Wikoff, ToxStrategies, Inc.

Application of omic technology for estimation of toxicological potency
Scott Auerbach, NIEHS, NTP

Everything Else: Computational Exposure and Dosimetry Context for Risk Analysis
John Wambaugh, United States EPA


10:30 AM to 12:30 PM | Symposium 4: The Graham Walker Symposium: Complexity of Cellular Responses to DNA Damage

Sponsored by: Carleton University2

Chairs | Iain Lambert & Bruce McKay, Carleton University, Ottawa, Canada

Translesion synthesis: From cancer resistance to host-pathogen interactions
Nimrat Chatterjee, The Larner College of Medicine at The University of Vermont, Burlington, Vermont, United Sates 

RNA-DNA hybrids cause genome-wide instability through nucleobase deamination and genomic rearrangements in bacteria
Lyle Simmons, University of Michigan, Ann Arbor, Michigan, United States

Insights Into How Bacteria Manage the Actions of Their DNA Polymerases
Mark Sutton, University of Buffalo, Buffalo, New York, United States

Concluding Remarks
Graham Walker, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States


3 PM to 5 PM | Symposium 5: Genotoxic Hazards of Air Pollution – A Global Perspective

Chairs | Paul A. White, Health Canada, Ottawa, Canada, Gisela de Aragão Umbuzeiro, State University of Campinas, Campinas, Brazil, David DeMarini, University of North Carolina, Chapel Hill, North Carolina, United States

Mutagenicity and Carcinogenicity of the Gas Phase and Particulate Components of Polluted Air
David DeMarini, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, United States

IARC Evaluation of Air Pollution Carcinogenicity: Supporting Mechanistic Evidence
Paul White, Health Canada, Ottawa, Ontario, Canada

Comparative Genotoxicity of Airborne Particulate Matter from Three Continents
Gisela Aragão Umbuzeiro, State University of Campinas, Campinas, Brazil

Mutagenic Hazards of Air Pollution in Asia
Kazuichi Hayakawa, Kanazawa University, Nomi-City, Ishikawa-Prefecture, Japan

Association Between Particulate Matter Abundance and the Mutagenic Activity of Polluted Air
Tiziana Schilirò, Department of Public Health and Pediatrics, University of Torino, Torino, Italy 


3 PM to 5 PM | Symposium 6: In Vitro Approaches for Risk Assessment

Chairs | Olivier Taboureau, Université de Paris, Paris, France, Xiaoqing (Carol) Guo, National Center for Toxicological Research, FDA, Jefferson, Arkansas United States, Ji-Eun Seo, National Center for Toxicological Research, FDA, Jefferson, Arkansas, United States

High-throughput Molecular Profiling Assays and Potential Applications in Chemical Risk Assessment
Joshua Harrill, U.S. Environmental Protection Agency, Durham, North Carolina, United States

Using In Vitro to In Vivo Extrapolation (IVIVE) to Apply Genetic Toxicity Data to Regulatory Risk Assessment
Marc Beal, Health Canada, Ottawa, Ontario, Canada

Genotoxicity Assessment of Nanoparticles in Advanced Liver and Lung Models
Elisabeth Elje, NILU-Norwegian Institute for Air Research, Kjeller, Norway

Use of in vitro 3D tissue models in genotoxicity testing
Stefan Pfuhler, Procter & Gamble, Cincinnati, Ohio, United States

Improving the Utility of In Vitro Screening Through Combined In Silico Modeling to Better Predict and Test Health Risks of Environmental Chemicals
Julia Rager, University of North Carolina, Chapel Hill, North Carolina, United States


3 PM to 5 PM | Symposium 7: Impact of Obesity on DNA Stability and its Health Consequences

Chairs | Siegfried Knasmueller, Institute of Cancer Research, Medical University Vienna, Vienna, Austria, Helga Stopper, Institute of Pharmacology and Toxicology, University of Wuerzburg, Wuerzburg, Germany, Vanessa Moraes de Andrade, Laboratorio de Immunologia e Mutagenese, UNESC, Santa Catarina, Brazil

Obesity and DNA Damage – an Overview
Siegfried Knasmueller, Institute of Cancer Research, Medical University, Vienna, Austria

Impact of Obesity on DNA Structure Induced Genetic Stability
Karen Vasquez, Division of Pharmacology and Toxicology, College of Pharmacology, Univ. of Texas, Austin, Texas, United States

Prevention of Obesity Induced DNA Damage by Dietary Antioxidants
Vanessa Moraes de Andrade, Laboratorio de Immunologia e Mutagenese, Universitade de Extremo Sul Catarinense (UNESC), Criciuma, Santa Catarina, Brazil

Reduction of Genomic Damage by Weight Loss
Helga Stopper, Institute of Pharmacology and Toxicology, University of Wuerzburg, Wuerzburg, Germany

Association Between Dietary Intervention and Telomere DNA Repair Dynamics, Implications on Obesity Related Disorders
Prakash HandeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore


3 PM to 5 PM | Symposium 8: DNA Cross-Link Repair and Health

Chairs | Sara Frias, Instituto de Investigaciones Biomédicas, UNAM/Instituto Nacional de Pediatría, Mexico City, Mexico,  Alan D. D’Andrea, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States, Alfredo Rodríguez, Harvard Medical School/Instituto Nacional de Pediatría, Mexico City, Mexico

The FA/BRCA Pathway; Cellular and Clinical Consequences
Sara Frias, Instituto de Investigaciones Biomédicas UNAM, Instituto Nacional Pediatria, Mexico City, Mexico

Cell Fate Decisions in the Face of DNA Damage
Alfredo Rodríguez, Instituto de Investigaciones Biomédicas,UNAM, Mexico City, Mexico

Fanconi Anemia: From DNA Interstrand Crosslink Repair to Novel Therapies
Jordi Surrallés, Servei de Genètica, Hospital de Sant Pau, Laboratoris LabSantPau, Barcelona, Spain

Ovarian Cancer as a Disease of DNA Repair
Liisa Kauppi, Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Finland


MONDAY, AUGUST 29, 2022

10:30 AM to 12:30 PM | Symposium 9: Cancer Genomics Provides Insight into Cancer Etiology, Progression and Therapeutic Response

Chairs | Barbara Parsons, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas, United States, Jiri Zavadil, International Agency for Research on Cancer, Lyon, France, Kelly Harris, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas, United States

Epigenetic Mechanisms Underlying Tumorigenesis and Approaches for Epigenetic Therapy
Daniel De Carvalho, Princess Margaret Cancer Centre, Toronto, ON, Canada

Immunogenomic Profiling of Tumour Microenvironments to Understand Cancer Treatments
Trevor Pugh, Princess Margaret Cancer Centre, Toronto, ON, Canada

Chemical-induced Somatic Mutation Signatures Identified by Next-generation Sequencing
Shoji Matsumura, R&S Safety Science Research, Kao Corporation, Japan

Multi-omics Analysis in Experimental Models of Carcinogen-mediated, Progressive Cell Transformation
Michael Korenjak, International Agency for Research on Cancer, Lyon, France

Variation in Cancer Driver Mutation Levels as a Metric of Clonal Expansion for Cancer Risk Assessment
Barbara Parsons, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, United States


10:30 AM to 12:30 PM | Symposium 10: Developing Integrated Approaches to Testing and Assessment (IATA) Using an Adverse Outcome Pathway (AOP) Framework

Chairs | Anax Oliveria, Lhasa Limited, Leeds, United Kingdom, Bette Meek, University of Ottawa, Ottawa, Canada

Activation Levels of MIE Transcriptional Biomarkers Identify Liver Tumorigenic Dose Levels
Chris Corton, U.S. EPA, Research Triangle Park, North Carolina, United States

Update on the ongoing OECD Validation of the ToxTracker Assay for Genotoxic Mode of Action Assessment
Giel Hendriks, Toxys, Leiden, The Netherlands

Developing integrated approaches to testing and assessment (IATA) using an adverse outcome pathway (AOP) framework
Anthony Lynch, GSK, Hertfordshire, England

Integration of Data with AOPs to Support Genotoxicity Assessment
Steven Kane, Lhasa Limited, Leeds, West Yorkshire, England

Computational Solutions to Support the Application of AOPs in Safety Assessment,
Crina Heghes, Lhasa Limited, Leeds, West Yorkshire, England


10:30 AM to 12:30 PM | Symposium 11: Consequences of Pharmaceutical and Chemicals for Male and Female Germ Cells and Heritability

Chairs | Jill Escher, Escher Fund for Autism, San Jose, California, United States, Bernard Robaire, McGill University, Montreal, Canada

Paternally Mediated Developmental Toxicity
Bernard Robaire, McGill University, Montreal, Canada

Polycomb Dependent Epigenetic Programming in Oocytes: Setting Developmental Outcomes for the Next Generation
Patrick Western, Hudson Institute for Medical Research, Melbourne, Australia

Germline Exposure to Sevoflurane Results in Dysregulation of Brain-Related Genes in Offspring
Vesna Jevtovic-Todorovic, University of Colorado, Aurora, Colorado, United States

General Anesthetics Induce Epigenetic Alterations in Germ Cells that Result in Autism-like Behaviors
Hsiao-Lin V. Wang, University, Atlanta, Georgia, United States


10:30 AM to 12:30 PM | Symposium 12: How Cells Tolerate and Replicate DNA Damage?

Chairs | Carlos FM Menck, University of Sao Paulo, Sao Paulo, Brazil, Vanesa Gottifredi, Fundación Instituto Leloir, Buenos Aires, Argentina

New Aspects on Pol Zeta Regulation and Function in Mammalian Cells
Patricia Kannouche, Institut Goustave Roussi, Villejuif, France

Non-TLS (Translesion DNA Synthesis) Functions of TLS Polymerases
Vanesa Gottifredi, Fundación Instituto Leloir, Buenos Aires, Argentina

Linking DNA Replication Fork Dynamics with Chemotherapy Response
Alessandro Vindigni, Washington University School of Medicine, Saint Louis, Missouri, United States

The Essential Role of Oxidative Stress In Translesion Synthesis Deficient Human Patients Cells (XP-V)
Natalia Cestari Moreno, National Institutes of Health, Rockville, MD, USA and Universidade de São Paulo, SP, Brazil


TUESDAY, AUGUST 30, 2022

10:30 AM to 12:30 PM | Symposium 13: De Novo Germline Mutations and Environmental Mutagenesis

Chairs | Kenichi Masumura, Division of Genetics and Mutagenesis, National Institute of Health Sciences, Kanagawa, Japan, Jonatan Axelsson, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden, Mathia
Colwell, University of Minnesota, St. Paul, United States

Mutagenicity in Germ Cells and De novo Mutations in the Offspring
Kenichi Masumura, Division of Genetics and Mutagenesis, National Institute of Health Sciences, 3-25-26 Tonomachi, Kanagawa, Japan

Analysis of De novo Germline Mutations in DNA Repair Deficient Mice Lines
Mizuki Ohno, Department of Medical Biophysics and Radiation Biology, Faculty of Medical Science, Kyushu University 3-1-1, Maidashi, Higashi-ku, Japan

Duplex Sequencing for Mutations in Blood and Spermatozoa from Young Men – A Pilot Study
Jonatan Axelsson, University of Ottawa, Ottawa, Canada

Harnessing Genomics Technologies for Assessing Germ Cell Mutagenicity in Humans and Laboratory Animals
Francesco Marchetti, Health Canada, Ottawa, Canada


10:30 AM to 12:30 PM | Symposium 14: New Tools in Carcinogenicity Testing

Chairs | Patricia Escobar, Merck & Co. Inc., West Point, United States, Barbara Parsons, US Food & Drug Administration, National Center for Toxicological Research Jefferson, United States, Xilin "Shan" Li, National Center for Toxicological Research, Jefferson, United States

State of the Science in Assessment of Carcinogenic Potential and Updates on ICH S1
Frank Sistare, Merck & Co. Retired, West Point, Pennsylvania, United States

Toxicogenomics in Carcinogenic Risk Assessment
Heidrun Ellinger-Zeigelbauer, Bayer Health Care, Leverkusen, Germany

Duplex Sequencing for Quantitative Detection of Clonal Expansions for the in vivo Assessment of Nongenotoxic Carcinogens
Keith Tannis, Merck & Co, West Point, Pennsylvania, United States

Relationship Between Cancer Driver Mutation Based Biomarkers and Tissue-specific Tumor Susceptibility in Rodents
Kelly Harris, US Food & Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas, United States


10:30 AM to 12:30 PM | Symposium 15: New Approaches for Informing Population Variability in Chemical Risk Assessment

Chairs | Catherine Gibbons, US EPA, Washington, D.C., United States, Michael Stewart, US EPA, Washington, D.C., United States, Chelsea Weitekamp, US EPA, Washington, D.C., United States

New Approaches in cancer risk assessment: why study design matters
Mary Beth Terry, Columbia Mailman School of Public Health, New York City, New York, United States

Application of Bayesian and Probabilistic approaches for Cancer Dose-Response Assessment incorporating Model Uncertainty and Human Variability
Weihsueh Chiu, Texas A&M University, College Station, Texas, United States

Approaches to Addressing Variability at OEHHA
Vince Cogliano, California Environmental Protection Agency, Sacramento, California, United States


10:30 AM to 12:20 PM | Symposium 16: From Genomes to Ecosystems: What Are the Ecological Consequences of Genotoxicity?

Chairs | Jason O'Brien, Environment and Climate Change Canada, Ottawa, Canada, Gisela de Aragão Umbuzeiro, Universidade Estadual de Campinas, Campinas, Brazil, Awadhesh Jha, University of Plymouth, Plymouth, United Kingdom, Helina Gyasi, University of Ottawa, Ottawa, Canada

From Molecules to Ecosystems: An AOP-Based Perspective on the Current Status of the Field of Ecogenotoxicology
Jason O'Brien, National Wildlife Research Centre, Environment and Climate Change Canada, Ottawa, Canada

Knowing the Resistance: Omics for Screening and Understanding the Impacts of Insecticide Resistance in Non-target Species
Helen Poynton, School for the Environment, University of Massachusetts, Boston, United States

Ecogenotoxicological Effects Related to Coal Mining and Burning
Juliana da Silva, Universidade La Salle, Canoas, Brazil

Investigating the Genotoxicity of Polycyclic Aromatic Compounds from the Athabasca Oil Sands Area in Wildlife
Helina Gyasi, University of Ottawa, Ottawa, Canada

An Integrated Approach to Assess Impact of Emerging Contaminants on Aquatic Organisms
Awadhesh Jha, University of Plymouth, Plymouth, England, United Kingdom


10:30 AM to 12:30 PM | Symposium 17: Polynucleotide Signatures and Regulation of Genotoxin Stress Response

Chairs | Robert Sobol, Mitchell Cancer Institute, University of South Alabama, Mobile, United States, Bret Freudenthal, University of Kansas Medical Center, Kansas City, United States, Aishwarya Prakash, Mitchell Cancer Institute, University of South Alabama, Mobile, United States

DNA Damage and Repair Processes Shape Mutational Signatures
Joanna Loizou, Comprehensive Cancer Centre, Medical University of ViennaVienna, Austria 

RNA-mediated Regulation of Double Strand Break Repair
Youngkyu Jeon, School of Biological Sciences, Georgia Institute of Technology, Georgia, United States

Poly-ADP-ribose in DNA Repair Regulation and Cellular Response to Genotoxins
Robert Sobol, Mitchell Cancer Institute, University of South Alabama, Mobile, United States


3 PM to 5 PM | Symposium 18: Personalized Cancer Risk and Prevention: Models Integrating Genetics, Infection, Diet, Exercise and Other Factors for Specific Cancers

Chairs | Rosalie Lijinsky, Silver Spring, Maryland, United States, Jonatan Axelsson, Division of Occupational and Environmental Medicine, Lund, Sweden, Clarissa Ribeiro Reily ROCHA, Departamento de
Microbiologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, Brazil

Shifting the Paradigm from Cancer Risk Assessment to Personalized Cancer Prevention
Dan Levy , Silver Spring, Maryland, United States

Colorectal Cancer Risk Factors and their Potential for Precision Prevention
Mingyang Song, Harvard School of Public Health, Cambridge, Massachusetts, United States

Risk Prediction of Gastric Cancer in Asian Populations: its Potential Application to Personalized Prevention and Screening
Shoichiro Tsugane, National Institutes of Biomedical Innovation, Health and Nutrition, Saito Asagi, Ibaraki City, Osaka, 567-0085, Japan


3 PM to 5 PM | Symposium 19: Risk Assessment of Low-Dose Rate Radiations: Lessons from the Fukushima Nuclear Accident

Chairs |Takayoshi Suzuki, National Institute of Health Sciences, Kawasaki, Japan, Yoshihisa Matsumoto, Tokyo Institute
of Technology, Tokyo, Japan

Long-term Strategies for Thyroid Health Monitoring After Nuclear Accidents: Recommendations from an Expert Group Convened by IARC
Kayo Togawa, International Agency for Research on Cancer, World Health Organization, Lyon, France

Risk Assessment in Human Population Exposed to Low-dose Radiation: A Challenging Task for Radiation Protection Science
Birajalaxmi Das, Bhabha Atomic Research Centre (BARC), Trombay, Mumbai, India

Experimental studies on the biological effects of chronic low dose-rate radiation exposures in mice
Ignacia Braga Tanaka, Advanced Molecular Bio-Sciences Research Center, Institute for Environmental Sciences,
Hacchazawa, Takahoko. Rokkasho, Aomori, Japan

Fukushima Daiichi Nuclear Power Station Accident from the aspect of radiation biology and risk communication
Yoshihisa Matsumoto, Ookayama, Meguro-ku, Tokyo, Japan


3 PM to 5 PM | Symposium 20: Novel Strategies for Investigating the Incidence and Mechanisms of In Vivo Mutations

Chairs | Steve Rozen, Duke-NUS Centre for Computational Biology, Duke-NUS Medical School, Singapore, Singapore,
Bevin Engelward, MIT Biological Engineering, Cambridge, United States

Experimental Delineation of Mutational Signatures
Jiri Zavadil, International Agency for Research on Cancer, WHO, Lyon, France

Mutational Signatures of Environmental and Chemotherapeutic Agents in Human Stem Cells and Organoids
Jill Kucab, Department of Analytical, Environmental and Forensic Sciences, King’s College, London, United Kingdom

Opportunities and Challenges in Using Mutational Signature Analysis to Illuminate Cancer Biology and Epidemiology
Steve Rozen, Duke-NUS Centre for Computational Biology, Duke-NUS Medical School, Singapore

The Causes Underlying Human Somatic Mutagenesis
Joanna Loizou, Center for Cancer Research, Medical University of Vienna, Vienna, Austria

Application of Mutational Signatures of Carcinogens as Biomarkers of Cancer
Bogdan Fedeles, MIT Departments of Chemistry and Biological Engineering, Cambridge, Massachusetts, United States


3 PM to 5 PM | Symposium 21: Role of RNA in DNA Repair

Chairs | Mats Ljungman, University of Michigan, Ann Arbor, United States, Heather O'Hagan, University of Indiana, Bloomington, United States

How DNA Damage Affects RNA Splicing
Manuel Munoz, University of Buenos Aires, Argentina

Molecular Mechanisms in Transcription-coupled DNA Repair
Martijn Luijsterburg, Leiden University, The Netherlands

Non coding RNA synthesis at DNA lesions
Fabrizio d'Adda di Fagagna, IFOM Milan, Italy


THURSDAY, SEPTEMBER 1, 2022

10:30 AM to 12:30 PM | Symposium 22: Dynamics of Mutation Acquisition in Somatic Cells: SNVs and SVs in the Brain, Blood and Beyond

Chairs | Thomas Wilson, University of Michigan, Ann Arbor, Michigan, United States, Thomas Glover, University of Michigan, Ann Arbor, Michigan, United States, Natalie Saini, Medical University of South Carolina, Charleston, United States

Somatic Mutations in Normal Tissues
Peter Campbell, Wellcome Sanger Institute, United Kingdom

Novel Approaches for Structural Variant Detection in Single Cells
Jan Korbel, EMBL, Heidelberg, Germany

Oncologic Therapy Shapes the Fitness Landscape of Clonal Hematopoiesis
Elli Papaemmanuil, Memorial Sloan Kettering Cancer Center, New York City, New York, United States

Programmed and Sporadic Mutations in Normal Brain Function and Cancer
Bjoern Schwer, University of California, San Francisco, California, United States

Lessons from the Brain Somatic Mosaicism Network
Michael J. McConnell, Lieber Institute for Brain Development, Baltimore, Maryland, United States


10:30 AM to 12:30 PM | Symposium 23: Managing Genes in Space

Chairs | William Kaufmann, Past-President of EMGS, Durham, North Carolina, United States, Vinita Chauhan, Health
Canada, Ottawa, Canada

Effects of Space Radiation on Brain Structure and Function
Janet Baulch, University of California, Irvine, California, United States

Effects of Galactic Cosmic Rays and Other Environmental Factors in Space on the Cardiovascular System
Marjan Boerma, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

Individual Susceptibility to Cancer from Space Radiation Exposure
Michael Weil, Colorado State University, Fort Collins, Colorado, United States


10:30 AM to 12:30 PM | Symposium 24: Using Quantitative Genetic Toxicology to Advance the Assessment of Genotoxic Impurities in Pharmaceuticals

Chairs | George Johnson, Swansea University, Swansea, United Kingdom, Andreas Zeller, Hoffman La Roche, Basel, Switzerland

Quantitative Analysis of In Vivo Mutagenicity Doseresponse Data for Risk Assessment and Regulatory Decision-making: A Case Study of Alkylnitrosamines
George Johnson, Swansea University, Swansea, United Kingdom

Current Regulatory Risk Assessment Procedure and Regulatory Concerns with Using Quantitative Genetic Tox Data for Risk Assessment
Roland Frotschl, BfArM, Germany

NDMA induced genotoxicity in the low dose region in Muta™Mouse
Anthony Lynch, GlaxoSmithKline, London, England, United Kingdom

Empirical Testing of an Uncertainty Factor to Address Inter-Individual Variation in DNA Repair Genes in the Derivation of Genotoxicity Health Based Guidance Values
Lauren Gallent, University of Ottawa, Ottawa, Ontario, Canada


10:30 AM to 12:30 PM | Symposium 25: R-loop Roadblocks to Transcription and Replication

Chairs | Philip Hanawalt, Department of Biology, Stanford University, Stanford, United States, Andrés Aguilera, Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Seville, Spain, Yesenia Rodriguez, National Institute of Environmental Health Sciences Biology Laboratory, National Institute of Environmental Health Sciences, Durham, United States 

RNA-mediated Transcription-replication Conflicts as a Source of Genome Instability
Andrés Aguilera, Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Seville, Spain

Mechanisms for RNA-Mediated Genome Instability
Karlene Cimprich, Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, United States

Investigating the Reasons Behind How R-Loops Can Become Deadly Upon Replication-transcription Conflicts
Houra Merrikh, Department of Biochemistry, Vanderbilt University, Nashville, Tennessee, United States

Toxic R-loops as a Cause and Consequence of Replication Stress
Philippe PaseroInstitut de Génétique Humaine, CNRS and Université de Montpellier, Equ ipe Labélisée Ligue


1:30 PM to 3:30 PM | Symposium 26: International Workshop on Genotoxicity Testing: Summary of Consensuses

Chairs | Hans-Joerg Martus, Novartis, Basel, Switzerland, David Kirkland, Kirkland Consulting, Tadcaster, United Kingdom, Andreas Zeller, F.Hoffmann, La-Roche, Basel, Switzerland 

Transcriptomic Biomarkers
Roland Froetschl, Federal Institute for Drugs and Medical Devices, Bonn, Germany

Predictivity of In Vitro Genotoxicity Testing, a Mathematical Modelling Approach
Mirjam Luijten, National Institute for Public Health and the Environment (RIVM), Bilthoven,The Netherlands

Genotoxicity Dose-response Analysis for Potency Comparisons and Risk Assessment
Paul White, Health Canada, Ottawa, Canada

In Vivo Strategies
Carol Beevers, Broughton-Group, Earby, Lancashire, United Kingdom

Statistical Approaches and Data Interpretation
Stephen Dertinger, Litron Laboratories, Rochester, New York, United States

Epigenotoxicity and Germ Cell Effects
Roger Godschalk, Maastricht University, Maastricht, The Netherlands

Gene Therapy
Silvana Libertini, Novartis Institutes for BioMedical Research, Basel, Switzerland


1:30 PM to 3:30 PM | Symposium 27: Genome Editing: Intentional Mutagenesis of the Genome and Implications for Human Health

Chairs | P.J. Brooks, NCATS, NIH, Bethesda, United States 

Empowering Genome Editing Technologies Through Standards and Measurement Confidence
Samantha Maragh, National Institute of Standards and Technology, Gaithersburg, Maryland, United States

Profiling cell type specificity and adverse events of genome editing nucleases in the brain and retina using single cell transcriptomics
Krishanu Saha, The Wisconsin Institute for Discovery, Madison, Wisconsin, United States

Understanding Human Genetic Variation with Precision Genome Editing Tools
Alexis Komor, University of California, San Diego, California, United States


1:30 PM to 3:30 PM | Symposium 28: Carcinogens, Carcinogenesis and Cancer: Application of Artificial Intelligence and Machine Learning

Chairs | Luoping Zhang, School of Public Health, University of California, Berkeley, United States, Maria Zhivagui, Department of Cellular and Molecular Medicine, University of California, San Diego, United States

How Artificial Intelligence (AI) Can Beat Animal Testing at Finding Toxic Chemicals as Potential Carcinogens
Thomas Hartung, Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States

Predicting the Binding of Small Molecules to Nuclear Receptors Using Machine Learning and Molecular Modeling Techniques
Azhagiya Singam, Molecular Graphics and Computation Facility, College of Chemistry, University of California, Berkeley, California, United States

Benchmarking Artificial Intelligence and Machine Learning (AI/ML) Based Methods for Cancer Mutation Detection
Joshua Xu, Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US FDA, Jefferson, Arkansas, United States

Mutational Signatures and the Etiology of Human Cancers
Maria Zhivagui, Department of Cellular and Molecular Medicine, University of California, San Diego, California, United States

A Multi-omic Approach and Bioinformatic Analysis of Exposures to Chemical Carcinogens
Luoping Zhang, School of Public Health, University of California, Berkeley, California, United States


1:30 PM to 3:30 PM | Symposium 29: Approaches for Studies of DNA Damage and Repair with Applications in Human Biomonitoring and Disease Risk Prediction

Chairs | Andrew Collins, University of Oslo, Oslo, Norway, Bevin Engelward, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States, Sabine Langie, Maastricht University, Maastricht, Netherlands

The Comet Assay: Past Success and Future Promise
Andrew Collins, University of Oslo, Oslo, Norway 

Measuring Nucleotide Excision Repair in at Risk Populations
Laura Neidernhoffer, University of Minnesota, School of Medicine, Minneapolis, Minnesota, United States

The Comet Assay as a Human Biomonitoring Tool
Sabine Langie, Maastricht University, Maastricht, The Netherlands 

Use of the CometChip for Public Health and Molecular Epidemiology
Bevin Engelward, Massachusetts Institute of Technology, Boston, Massachusetts, United States


1:30 PM to 3:30 PM | Symposium 30: Approaches for Studies of DNA Damage and Repair with Applications in Human Biomonitoring and Disease Risk Prediction

Chairs | Jennifer Keir, University of Ottawa, Ottawa, Canada, Yasunobu Aoki, National Institute for Environmental Studies, Tsukuba, Japan 

Genotoxic Effect of Polycyclic Aromatic Hydrocarbons Alone or in Mixture in Human Cells
Marc Audebert, l'Institut national de recherche pour l'agriculture, l'alimentation et l'environnement, Université Paris-Saclay, Paris, France

Polycyclic Aromatic Compound Mixtures Research to Inform Component-based Risk Assessment
Cynthia Rider, NIEHS National Toxicology Program, Durham, North Carolina, United States

In Vivo Mutagenesis of PAHs and Related Compounds Contained in Airborne Particles
Yasunobu Aoki, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan

Biomonitoring Studies of Exposure to Airport Emissions, Diesel Exhaust and Firefighting
Anne Thoustrup Saber, The National Research Centre for the Working Environment, Copenhagen, Denmark

Firefighters’ Combustion-derived PAH Exposures and Investigating Exposure Reduction Methods
Jennifer Keir, University of Ottawa, Ottawa, Canada