SYMPOSIA

A total of 30 symposia are included in the main program of the meeting. Symposia are an equal balance of applied and basic science spanning the specialty areas and are summarized below:

SUNDAY, AUGUST 29, 2021

10:30 AM to 12:30 PM | Advancing Mechanistic Analyses in Genetic Toxicology Using High-Content and High-Throughput Methodologies
Chairs | Alexandra Long (University of Toronto); Dan Roberts (Charles River Laboratories); Eunnara Cho (Carleton University)
Planned Speakers | David Andrews (Sunnybrook Research Institute & University of Toronto, Toronto, ON, CANADA), Paul Rees (Swansea University, Swansea, UNITED KINGDOM), Steve Bryce/Bevin Engelward/Julie Buick (Litron Laboratories/Massachusetts Institute of Technology/Health Canada), Joleen Hanna (Health Canada, Ottawa, ON, CANADA), John Wills (University of Cambridge, Cambridge, UNITED KINGDOM)

10:30 AM to 12:30 PM | Analyses of DNA Modification and Their Roles in Human Carcinogenesis
Chairs | Haruhiko Sugimura (Hamamatsu University School of Medicine, Hamamatsu, JAPAN), Silvia Balbo (University of Minnesota, Minneapolis)
Planned Speakers | Yukari Totsuka (National Cancer Center Research Institute, Tokyo, JAPAN), Haruhiko Sugimura (Hamamatsu University School of Medicine, Hamamatsu, JAPAN), Silvia Balbo (University of Minnesota, Minneapolis, MN, USA), Yuval Ebenstein (Tel Aviv University, Tel Aviv, ISRAEL)

10:30 AM to 12:30 PM | Application of Computational Modeling and Bioinformatics in Toxicological Assessment
Chairs | Julia Rager (University of North Carolina), Marc Beal (Health Canada)
Planned Speakers | Olivier Thierry Taboureau (Université de Paris, FRANCE), Wieda Tong (US FDA, National Center for Toxicological Research, Jefferson, AR, USA), Danielle Wikoff (ToxStrategies, Ashville, NC, USA), Scott Auerbach (NIEHS, National Toxicology Program, Research Triangle Park, NC, USA), John Wambaugh (US EPA, Research Triangle Park, NC, USA)

10:30 AM to 12:30 PM | The Graham Walker Symposium: Complexity of Cellular Responses to DNA Damage
Chairs | Iain Lambert (Carleton University), Bruce McKay (Carleton University)
Planned Speakers | Graham Walker (Massachusetts Institute of Technology, Cambridge, MA, USA), Mark Sutton (University of Buffalo, NY, USA)

3 to 5 PM | DNA Cross-Link Repair and Health
Chairs | Sara Frias (Instituto de Investigaciones Biomédicas, UNAM/Instituto Nacional de Pediatría), Alan D. D’Andrea (Dana-Farber Cancer Institute, Harvard Medical School, Boston), Alfredo Rodríguez (Harvard Medical School, Boston Instituto Nacional de Pediatría)
Planned Speakers | Sara Frias ((Instituto de Investigaciones Biomédicas, UNAM/Instituto Nacional de Pediatría, Mexico City, MEXICO), Alan D. D’Andrea (Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA), Alfredo Rodríguez (Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México/Instituto Nacional de Pediatría, Mexico City, MEXICO), Anniina Färkkilä, (Faculty of Medicine and Department of Obstetrics and Gynecology, Helsinky University Hospital, University of Helsinki, Helsinki, FINLAND), Jordi Surrallés (Hospital de Sant Pau, Barcelona, SPAIN)

3 to 5 PM | From Genomes to Ecosystems: What Are the Ecological Consequences of Genotoxicity?
Umbuzeiro (State University of Campinas), Awadhesh Jah (University of Plymouth), Helina Gyasi (University of Ottawa)
Planned Speakers | Jason O’Brien (Environmental and Climate Change Canada, Ottawa, ON, CANADA), Helen Poynton (University of Massachussetts, Boston, MA, USA), Juliana da Silva (Universidade La Salle, Canoas, BRAZIL), Helina Gyasi (University of Ottawa, Ottawa, ON, CANADA), Awadhesh Jah (University of Plymouth, Plymouth, UNITED KINGDOM)

3 to 5 PM | Genotoxic Hazards of Air Pollution – A Global Perspective
Chairs | Paul A. White (Health Canada), Gisela de Aragão Umbuzeiro (State University of Campinas), Francine Inforçato Vacchi (Mérieux Nutrisciences Brazil)
Planned Speakers | Daniel Costa (University of North Carolina, Chapel Hill, NC, USA), Paul White (Health Canada, Ottawa, ON, CANADA), Gisela de Aragão Umbuzeiro (State University of Campinas, Limeira, BRAZIL), Kazuichi Hayakawa (Kanazawa University, Nomi-City, JAPAN), David DeMarini (University of North Carolina, Chapel Hill, NC, USA)

3 to 5 PM | Impact of Obesity on DNA Stability and its Health Consequences
Chairs | Siegfried Knasmueller (Medical University of Vienna, AUSTRIA), Helga Stopper (University of Wuerzburg), Vanessa Moraes de Andrade (UNESC)
Planned Speakers | Siegfried Knasmueller (Medical University of Vienna, AUSTRIA)

Karen Vasquez (University of Texas, Austin, TX, USA), Helga Stopper (University of Wuerzburg, Wuerzburg, GERMANY), Vanessa Moraes de Andrade (Universitade de Extremo Sul Catarinense, Criciuma, BRAZIL), Prakash Hande (National University of Singapore, SINGAPORE)

3 to 5 PM | In Vitro Approaches for Risk Assessment
Chairs | Olivier Taboureau (Université de Paris, FRANCE), Xiaoqing (Carol) Guo (US FDA, NCTR), Ji-Eun Seo (US FDA, NCTR)
Planned Speakers | Joshua Harill (Center for Computational Toxicology and Exposure, U.S. EPA, Research Triangle Park, NC, USA), Marc Beal (Health Canada, Ottawa, ON, CANADA), Elizabeth Elje (NILU-Norwegian Institute for Air Research, Kjeller, NORWAY), Stefan Pfuhler (Procter & Gamble, Cincinnati, OH, USA), Julia Rager (UNC Gillings School of Global Public Health, Chapel Hill, NC, USA)

MONDAY, AUGUST 30, 2021

10:30 AM to 12:30 PM | Cancer Genomics Provides Insight into Cancer Etiology, Progression and Therapeutic Response
Chairs | Barbara Parsons (US FDA, National Center for Toxicological Research), Jiri Zavadil (International Agency for Research on Cancer WHO), Kelly Harris (US FDA, National Center for Toxicological Research)
Planned Speakers | Daniel De Carvalho (Princes Margaret Cancer Centre, Toronto, ON, CANADA), Trevor Pugh (Princes Margaret Cancer Centre, Toronto, ON, CANADA), Shoji Matsumura (R&S Safety Science Research, Kao Corporation, Ichikai, JAPAN), Michael Korenjak (International Agency for Research on Cancer, Lyon, FRANCE), Barbara Parsons (US FDA, National Center for Toxicological Research, Jefferson, AR, USA)

10:30 AM to 12:30 PM | Consequences of Pharmaceutical and Chemicals for Male and Female Germ Cells and Heritability
Chairs | Jill Escher (Escher Fund for Autism), Bernard Robaire (McGill University)
Planned Speakers | Bernard Robaire (McGill University, Montreal, QC, CANADA), Patrick Western (Hudson Institute for Medical Research, Melbourne, AUSTRALIA), Stephen Matthews (University of Toronto, Toronto, ON, CANADA), Vesna Jevtovic-Todorovic (University of Colorado, Aurora, CO, USA), Hsaio-Lin V Wang (Emory University, Atlanta, GA, USA)

10:30 AM to 12:30 PM | Developing Integrated Approaches to Testing and Assessment (IATA) Using an Adverse Outcome Pathway (AOP) Framework
Chairs | Chris Barber (Lhasa Limited), Bette Meek (University of Ottawa), Steven Kane (Lhasa Limited)
Planned Speakers | Anthony Lynch (GSK, Hertfordshire, UNITED KINGDOM), Giel Hendriks (Toxys, Leiden, THE NETHERLANDS), Chris Corton (US EPA, Research Triangle Park, NC, USA), Steve Kane (Lhasa Limited, Leeds, UNITED KINGDOM), Crina Heghes (Lhasa Limited, Leeds, UNITED KINGDOM)

10:30 AM to 12:30 PM | How Cells Tolerate and Replicate DNA Damage?
Chairs | Carlos F.M. Menck (Universidade de São Paulo), Vanesa Gottifredi (Fundación Instituto Leloir)
Planned Speakers | Vanesa Gottifredi (Fundación Instituto Leloir, Buenos Aires, ARGENTINA), Patricia Kannouche (Institut Gustave Roussy, Villejuif, FRANCE), Alessandro Vindigni (Washington University School of Medicine, Saint Louis, MO, USA), Natalia Cestari Moreno (Universidade de São Paulo, SP, BRAZIL)

TUESDAY, AUGUST 31, 2021

10:30 AM to 12:30 PM | De Novo Germline Mutations and Environmental Mutagenesis
Chairs | Kenichi Masumura (National Institute of Health Sciences), Jonatan Axelsson (Lund University), Mathia Colwell (University of Minnesota)
Planned Speakers | Kenichi Masumura (National Institute of Health Sciences, Kanagawa, JAPAN), Mizuki Ohno (Kyushu University, Fukuoka, JAPAN), Jeffrey Rosenfeld (Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA), Francesco Marchetti (Health Canada, Ottawa, ON, CANADA)

10:30 AM to 12:30 PM | New Approaches for Informing Population Variability in Chemical Risk Assessment
Chairs | Catherine Gibbons (US EPA), Michael Stewart (US EPA), Chelsea Weitekamp (US EPA)
Planned Speakers | Mary Beth Terry (Columbia Mailman School of Public Health, New York City, NY, USA), Weihsueh Chiu (Texas A&M University, College Station, TX, USA), Lauren Zeise (California EPA, Sacramento, CA, USA), Zachary Nagel (Harvard School of Public Health, Boston, MA, USA)

10:30 AM to 12:30 PM | Polynucleotide Signatures and Regulation of Genotoxin Stress Response
Chairs | Robert W. Sobol (University of South Alabama), Bret D. Freudenthal (University of Kansas Medical Center), Aishwarya Prakash (University of South Alabama)
Planned Speakers | Shana Sturla (ETH Zurich, Zurich, SWITZERLAND), Francesca Storici (Georgia Institute of Technology, Atlanta, GA, USA), Robert W. Sobol (University of South Alabama, Mobile, AL, USA)

10:30 AM to 12:30 PM | New Tools in Carcinogenicity Testing
Chairs | Patrica A. Escobar (Merck & Co. Inc), Barbara Parsons (US FDA, NCTR)
Planned Speakers | Frank Sistare (Merck & Co. Retired, USA), Heidrun Ellinger-Zeigelauer (Bayer Health Care, Leverkusen, GERMANY), Jan Willem van der Laan (Leiden University, Leiden, THE NETHERLANDS), Kelly Harris (US FDA, National Center for Toxicological Research, Jefferson, AR, USA)

3 to 5 PM | Personalized Cancer Risk and Prevention: Models Integrating Genetics, Infection, Diet, Exercise and Other Factors for Specific Cancers
Chairs | Rosalie Elespuru (US FDA, Center for Devices and Radiological Health, Silver Spring, USA), Catherine Fischer (US NCI, Division of Cancer Prevention, Bethesda, USA)
Planned Speakers | Rosalie Elespuru (US FDA, Center for Devices and Radiological Health, Silver Spring, USA), Daniel Krewski (University of Ottawa, Ottawa, CANADA), Shoichiro Tsugane (National Cancer Cente, Tokyo, JAPAN), Scott T. Leatherdale (University of Waterloo, Waterloo, CANADA)

3 to 5 PM | Role of RNA in DNA Repair
Chairs | Mats Ljungman (University of Michigan), Heather O’Hagan (Indiana University)
Planned Speakers | Alberto Kornblihtt (University of Buenos Aires, Buenos Aires, ARGENTINA), Martijn Luijsterburg (Leiden University, Leiden, THE NETHERLANDS), Fabrizio d’Adda di Fagagna (FIRC Institute of Molecular Oncology, Milan, ITALY)

3 to 5 PM | Novel Strategies for Investigating the Incidence and Mechanisms of In Vivo Mutations
Chairs | Steve Rozen (Duke-NUS Medical School), Bevin Engelward (Massachusetts Institute of Technology), Anroud Bout (Duke-NUS Medical School)
Planned Speakers | Jiri Zavadil (International Agency for Research on Cancer, Lyon, FRANCE), Jill Kucab (King’s College, London, UNITED KINGDOM), Natalie Saini (Medical University of South Carolina, Charleston, SC, USA), John Essigmann (Massachusetts Institute of Technology, Cambridge, MA, USA)

3 to 5 PM | Risk Assessment of Low-Dose Rate Radiations: Lessons from the Fukushima Nuclear Accident
Chairs | Takayoshi Suzuki (National Institute of Health Sciences), Yoshihisa Matsumoto (Tokyo Institute of Technology)
Planned Speakers | Kayo Togawa (International Agency for Research on Cancer, Lyon, FRANCE), Birajalaxmi Das (Bhabha Atomic Research Centre, Mumbai, INDIA), Ignacia Braga Tanaka (Institute for Environmental Sciences, Rokkasho, JAPAN), Yoshihisa Matsumoto (Tokyo Institute of Technology, Tokyo, JAPAN)

3 to 5 PM | Approaches for Studies of DNA Damage and Repair With Applications in Human Biomonitoring and Disease Risk Prediction
Chairs | Andrew Collins (University of Oslo), Bevin Engelward (Massachusetts Institute of Technology), Sabine Langie (Maastricht University)
Planned Speakers | Andrew Collins (University of Oslo, Oslo, NORWAY), Laura Neidernhoffer (University of Minnesota, Minneapolis, MN, USA), Sabine Langie (Maastricht University, Maastricht, THE NETHERLANDS), Bevin Engelward (Massachusetts Institute of Technology, Boston, MA, USA)

WEDNESDAY, SEPTEMBER 1, 2021

10:30 AM to 12:30 PM | Dynamics of Mutation Acquisition in Somatic Cells: SNVs and SVs in the Brain, Blood and Beyond
Chairs | Thomas E. Wilson (University of Michigan), Thomas W. Glover (University of Michigan), Natalie Saini (Medical University of South Carolina)
Planned Speakers | Peter J. Campbell (Wellcome Sanger Institute, Cambridge, UNITED KINGDOM), Jan O. Korbel (European Molecular Biology Laboratory, Heidelberg, GERMANY), Bjoern Schwer (University of California, San Francisco, CA, USA), Elli Papaemmanuil (Memorial Sloan Kettering Cancer Center, New York, USA)

10:30 AM to 12:30 PM | Using Quantitative Genetic Toxicology to Advance the Assessment of Genotoxic Impurities in Pharmaceuticals
Chairs | George Johnson (Swansea University), Andreas Zeller (F. Hoffmann - La Roche, GERMANY), Alexandra Long (University of Toronto)
Planned Speakers | George Johnson (Swansea University, Swansea, UNITED KINGDOM), Roland Frotschl (BfArM, Bonn, GERMANY), Michelle Kenyon (Pfizer, New York City, NY, USA), Alexandra Long (University of Toronto, Toronto, ON, CANADA)

10:30 AM to 12:30 PM | Managing Genes in Space
Chairs | William Kaufmann (Durham, NC, USA); Vinita Chauhan (Health Canada)
Planned Speakers | Janet Baulch (University of California, Irvine, CA, USA), Marjan Boerma (University of Arkansas for Medical Sciences, Little Rock, AR, USA), Michael Weil (Colorado State University, Fort Collins, CO, USA)

10:30 AM to 12:30 PM | Carcinogens, Carcinogenesis and Cancer: Application of Artificial Intelligence and Machine Learning
Chairs | Luoping Zhang (University of California, Berkeley), Maria Zhivagui (University of California, San Diego)
Planned Speakers | Thomas Hartung (Johns Hopkins University, Baltimore, MD, USA), Lila Kari (University of Waterloo, Waterloo, ON, CANADA), Kathleen Durkin (University of California, Berkeley, CA, USA), Maria Zhivagui (University of California, San Diego, CA, USA), Luoping Zhang (University of California, Berkeley, CA, USA)

THURSDAY, SEPTEMBER 2, 2021

1:30 to 3:30 PM | Genome Editing: Intentional Mutagenesis of the Genome and Implications for Human Health
Chairs | P.J. Brooks (Office of Rare Diseases Research, National Center for Advancing Translational Sciences, NIH)
Planned Speakers | Samantha Maragh (National Institute of Standards and Technologies, Gaithersburg, MD, USA), Krishanu Saha (The Wisconsin Institute for Discovery, Madison, WI, USA), Alexis Komor (University of California, San Diego, CA, USA)

1:30 to 3:30 PM | International Workshop on Genotoxicity Testing: Summary of Consensuses
Chairs | Hans-Jorge Martus (Novartis), David Kirkland (Kirkland Consulting)
Planned Speakers | Workgroup leaders will provide an update on the consensus and conclusion reached by the various workgroups

1:30 to 3:30 PM | Mutagenic Hazards of PAHs and PAH mixtures
Chairs | Jennifer Keir (University of Ottawa), Yasunobu Aoki (National Institute for Environmental Studies)
Planned Speakers | Marc Audebert (Institut National de la Recherche en Agriculture, Alimentation et Environnement, Paris, France), Cynthia Rider (NIEHS National Toxicology Program, Research Triangle Park, NC, USA), Yasunobu Aoki (National Institute for Environmental Studies, Ibaraki, JAPAN), Anne Thoustrup Saber (National Research Centre for the Working Environment, Copenhagen, DENMARK), Jennifer Keir (University of Ottawa, Ottawa, CANADA)

1:30 to 3:30 PM | R-loop Roadblocks to Transcription and Replication
Chairs | Philip Hanawalt (Stanford, University), Andrés Aguilera (Universidad de Sevilla-CSIC), Yesenia Rodriguez (National Institute of Environmental Health Sciences)
Planned Speakers | Andrés Aguilera (Universidad de Sevilla-CSIC, Seville, SPAIN), Karlene Cimprich (Stanford University School of Medicine, Stanford, CA, USA), Gaélle Legube (CNRS-University of Toulouse, Toulouse, FRANCE), Philippe Pasero (CNRS and Université de Montpellier, Montpellier, FRANCE)