13th International Conference on Environmental Mutagens

Maintaining Genomic Health in a Changing World

53rd Annual Meeting of the EMGS

August 27 - September 1, 2022 - Ottawa Canada

 

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ICEM 2022 Sponsors

Become a Sponsor  

Diamond Level: 
Morningside Foundation
NIEHS R13 Grant No. 5R13ES031435-03 
TwinStrand Biosciences


Platinum Level:
Escher Fund for Autism 

Health and Environmental Sciences Institute
Proctor & Gamble, Co. 
US-FDA R13 Grant No. 5R13FD006702-04
University of Ottawa 
MGI Americas Inc.
Carleton University
 


Gold Level:
Bristol Myers Squibb
Canadian Institutes for Health Research
Inotiv Inc.


Silver Level:
Burroughs Wellcome Fund

Elsevier
United Kingdom Environmental Mutagen Society
Gilead Sciences
National Cancer Institute (NCI)
Merck Research


Bronze Level:
Lhasa Limited
The Research Institute for Fragrance Materials

Moltox, Molecular Toxicology, Inc. 
BASF Corp.
Toxys B.V.
Litron Laboratories
Instem
Kao Corporation
MultiCASE


Supporter
Mutagen-Brasil

Johnson & Johnson
University of Michigan
John J. Nicolette, MS, DABT


Contributors
European Environmental Mutagenesis and Genomics Society

Japanese Environmental Mutagen and Genome Society
Journal of Biochemistry
Illumina
Pfizer Inc.
Environmental and Molecular Mutagenesis Journal 
Bill Kaufmann, PhD
Genetic Toxicology Association
Society of Toxicology


SYMPOSIA

A total of 30 symposia are included in the main program of the meeting. Symposia are an equal balance of applied and basic science spanning the specialty areas and are summarized below:

SUNDAY, AUGUST 28, 2022

10:30 AM to 12:30 PM | Symposium 1: Advancing Mechanistic Analyses in Genetic Toxicology Using High-Content and High-Throughout Methodologies

Sponsored by: TwinStrand Logo 2022

Chairs: Alexandra Long, Health Canada, Ottawa, Canada, Dan Roberts, Charles River Laboratories, Skokie, IL, USA, Eunnara Cho, Carleton University, Ottawa, Canada

Location: Confederation I - Level 4

10:30AM - 11:00AM | Evaluating Cellular Responses to Toxic Compounds by High Content Screening
David Andrews, Sunnybrook Research Institute & University of Toronto, Toronto, ON, Canada

11:00AM - 11:30AM | Deep Neural Networks to Automate Scoring of the Imaging Flow Cytometry In-Vitro Micronucleus Assay

Paul Rees, Swansea University, Swansea, United Kingdom

11:30AM - 11:40AM | Development of a Universal Machine Learning Model to Facilitate Interlaboratory Transferability of an In Vitro Multiplexed Genotoxicity Mode of Action Assay

Steve Bryce Litron Laboratories, Rochester, NY, USA

11:40AM - 11:50AM | High-Throughput Assessment of DNA Damage Using CometChip®

Bevin Page EngelwardMassachusetts Institute of Technology, Cambridge, MA, USA

11:50AM - 12:00PM | TGx-DDI for High-Throughput, High-Content Identification of DNA Damaging Substances

Carole L YaukUniversity of Ottawa, Ottawa, ON, Canada

12:00PM - 12:15PM | GeneTox21- An Integrated Platform for In Vitro Genetic Toxicity Assessment and Regulatory Evaluation of New and Existing Substances
Hannah Battaion, Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada

12:15PM - 12:30PM | High-Content Imaging and Deep Learning: Opportunities and Challenges in Toxicology
John Wills, University of Cambridge, Cambridge, United Kingdom


10:30 AM to 12:30 PM | Symposium 2: The Graham Walker Symposium: Complexity of Cellular Responses to DNA Damage

Sponsored by: Carleton University2

Chairs: Iain Lambert & Bruce McKay, Carleton University, Ottawa, ON, Canada

Location: Governor General I/II - Level 4

10:30AM - 11:00AM | RNA-DNA Hybrids Cause Genome-Wide Instability Through Nucleobase Deamination and Genomic Rearrangements in Bacteria
Lyle Simmons, University of Michigan, Ann Arbor, MI, USA

11:00AM - 11:30AM | Insights into How Bacteria Manage the Actions of Their DNA Polymerases
Mark Sutton, University at Buffalo, SUNY, Buffalo, NY, USA

11:30AM - 12:00PM | Translesion synthesis: From Cancer Resistance to Host-Pathogen Interactions
Nimrat Chatterjee M.Sc. Ph.D, The Larner College of Medicine at The University of Vermont, Burlington, VT, USA

12:00PM - 12:15PM | Unraveling DNA Polymerases Iota, Kappa and Eta Roles on Temozolomide Treatment

Marcela Teatin LatanciaBiomedical Science Institution - University of Sao Paulo, Sao Paulo, SP, Brazil

12:15PM - 12:30PM | Concluding Remarks
Graham Walker, Massachusetts Institute of Technology, Cambridge, MA, USA


10:30 AM to 12:30 PM | Symposium 3: Application of Computational Modeling and Bioinformatics in Toxicological Hazard and Risk Assessment

Chairs: Julia Rager, UNC-Chapel Hill, NC, USA; Marc Beal, Health Canada, ON, Canada; Scott Auerbach, NIEHS, Durham, NC, USA

Location: Confederation III - Level 4

10:30AM - 11:00AM | Systems Biology: Systematic Data Integration and Modeling for Toxicological Inference
Olivier Thierry Taboureau, University of Copenhagen, Copenhagen, Denmark

11:00AM - 11:30AM | Application of Artificial Intelligence in Toxicology
Weida Tong, US Food and Drug Administration, Silver Spring, MD, USA

11:30AM - 12:00PM | Applications of Literature Mining and Natural Language Processing to Evidence Mapping and Systematic Review
Daniele Wikoff, ToxStrategies, Inc., Asheville, NC, USA

12:00PM - 12:15PM | Genomic Dose Response: Modeling in Chemical Risk Assessment
Scott Auerbach, NIEHS, NTP, NC, USA

12:15PM - 12:30 PM | A Pathway Analysis and Connectivity Mapping Based Exploration of Oxidative Stress Mediated Genotoxicity Modes of Actions

K. Nadira De AbrewThe Procter & Gamble Company, Cincinnati, OH, USA


10:30 AM to 12:30 PM | Symposium 4: Analyses of DNA Modifications and Their Roles in Human Carcinogenesis

Sponsored by: MGI.png

Chairs: Haruhiko Sugimura, Hamamatsu University School of Medicine, Hamamatsu, Japan, Silvia Balbo, University of Minnesota, Minneapolis, MN, USA

Location: Confederation II - Level 4

10:30AM - 11:00AM | Human Adductomics, Challenges
Haruhiko Sugimura, Hamamatsu University School of Medicine, Hamamatsu, Japan

11:00AM - 11:30AM | Untargeted DNA Adductomics
Silvia Balbo, Masonic Cancer Center, Minneapolis, MN, USA

11:30AM - 12:00PM | An Experimental Tool-Box for Quantifying DNA Damage and Epigenetic Transformations
Yuval Ebenstein, School of Chemistry, Tel Aviv University, Tel Aviv, Israel

12:PM - 12:15PM | Discovery DNA Adductomics: An Innovative Tool for the Discovery of Unknown Genotoxins

Peter W VillaltaUniversity of Minnesota, Masonic Cancer Center, Department of Medicinal Chemistry, Minneapolis, MN, USA

12:15PM -12:30PM | Mechanisms of APOBEC3 Mutagenesis in Human Cancer Cells

Mia PetljakBroad Institute of MIT and Harvard, Cambridge, MA, USA


3 PM to 5 PM | Symposium 5: Genotoxic Hazards of Air Pollution – A Global Perspective

Chairs: Paul A. White, Health Canada, Ottawa, ON, Canada, Gisela de Aragão Umbuzeiro, State University of Campinas, Campinas, Brazil, David DeMarini, University of North Carolina, Chapel Hill, NC, USA

Location: Confederation I - Level 4

3:00PM - 3:30PM | IARC Evaluation of Air Pollution Carcinogenicity: Supporting Mechanistic Evidence
Paul White, Health Canada, Ottawa, ON, Canada

3:30PM - 4:00PM | Mutagenicity and Carcinogenicity of the Gas Phase and Particulate Components of Polluted Air
David DeMarini, (Retired)U.S. Environmental Protection Agency, Research Triangle Park, NC, USA

4:00PM - 4:30PM | Comparative Mutagenicity of Airborne Particulate Matter from Three Continents
Gisela Aragão Umbuzeiro, UNICAMP, LIMEIRA, Sao Paulo, Brazil

4:30PM - 4:45PM | Mutagenic Hazards of Air Pollution in Asia
Kazuichi Hayakawa, Kanazawa University, Nomi, Ishikawa, Japan

4:45PM - 5:00PM | Particulate Matter in North-West Italy During the COVID-19 Pandemic: Biological Effects.
Tiziana Schilirò, Department of Public Health and Pediatrics, University of Torino, Torino, Italy 


3 PM to 5 PM | Symposium 6: In Vitro Screening Approaches for Risk Assessment

Chairs: Olivier Taboureau, Université de Paris, Paris, France, Xiaoqing (Carol) Guo, National Center for Toxicological Research, FDA, Jefferson, AR, USA

Location: Confederation II - Level 4

3:00PM - 3:30PM | High-throughput Molecular Profiling Assays and Potential Applications in Chemical Risk Assessment
Joshua Harrill, U.S. Environmental Protection Agency, Durham, NC, USA

3:30PM - 4:00PM | Using In Vitro to In Vivo Extrapolation (IVIVE) to Apply Genetic Toxicity Data to Regulatory Risk Assessment
Marc Beal, Health Canada, Ottawa, ON, Canada

4:00PM - 4:15PM | How In Vitro 3D Tissue Models can be Utilized in the Assessment of Genotoxicity Risk
Stefan Pfuhler, Procter & Gamble, Cincinnati, OH, USA

4:15PM - 4:30PM | Improving the Utility of In Vitro Screening Through Combined In Silico Modeling to Better Predict and Test Health Risks of Environmental Chemicals
Julia Rager, University of North Carolina, Chapel Hill, NC, USA

4:30PM - 5:00PM | Genotoxicity Assessment of Nanomaterials in Advanced Liver and Lung Models
Elisabeth Elje, NILU - Norwegian Institute for Air Research, Kjeller, Norway, University of Oslo, Oslo, Norway


3 PM to 5 PM | Symposium 7: Impact of Obesity on DNA Stability and its Health Consequences

Chairs: Siegfried Knasmueller, Institute of Cancer Research, Medical University Vienna, Vienna, Austria, Helga Stopper, Institute of Pharmacology and Toxicology, University of Wuerzburg, Wuerzburg, Germany, Vanessa Moraes de Andrade, Laboratorio de Immunologia e Mutagenese, UNESC, Santa Catarina, Brazil

Location: Confederation III - Level 4

3:00PM - 3:30PM | Obesity and DNA Damage – an Overview
Siegfried Knasmueller, Center for Cancer Research, Medical University of Vienna, Vienna, Austria

3:30PM - 4:00PM | Impact of Obesity on Cancer-Associated Mutation Hotspots
Karen Vasquez, University of Texas at Austin, Austin, TX, USA

4:00PM - 4:15PM | Prevention of Obesity Induced DNA Damage by Dietary Antioxidants in Mice
Vanessa Moraes de Andrade, Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina – UNESC, Criciúma, Santa Catarina, Brazil

4:15PM - 4:45PM | Reduction of Genomic Damage by Weight Loss
Helga Stopper, University of Wuerzburg, Wuerzburg, Bavaria Germany

4:45PM - 5:00PM | Association Between Dietary Interventions and the Dynamics of Telomere DNA Repair: Implications for Obesity Related Disorders
Prakash HandeDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore


3 PM to 5 PM | Symposium 8: DNA Cross-Link Repair and Health

Chairs: Sara Frias, Instituto de Investigaciones Biomédicas, UNAM/Instituto Nacional de Pediatría, Mexico City, Mexico, Alfredo Rodríguez, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico

Location: Governor General I/II - Level 4

3:00PM - 3:05PM | Presentation of the Participants' CV Summaries
Sara Frias, PhD, and Dr. Alfredo Rodríguez, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, México

3:05PM - 3:20PM | The FA/BRCA Pathway; Cellular and Clinical Consequences of Its Failure
Sara Frias, Instituto de Investigaciones Biomédicas UNAM, Instituto Nacional Pediatria, Ciudad de México, México

3:20PM - 3:45PM | Fanconi Anemia: From DNA Interstrand Crosslink Repair to Novel Therapies
Jordi Surrallés, Sant Pau Institute Research Institute, IIB Sant Pau, Barcelona, Spain, Barcelona, Spain

3:45PM - 4:10PM | Cell Fate Decisions in Fanconi Anemia Cells in the Face of DNA Damage
Alfredo Rodríguez Gómez, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico

4:10PM - 4:35PM | Ovarian Cancer as a Disease of DNA Repair
Liisa KauppiUniversity of Helsinki, Helsinki, Finland

4:35PM - 4:45PM | DNA Containing Bulky DNA Adducts is Released from Keratinocytes after Genotoxin Exposure

M Alexandra CarpenterDepartment of Pharmacology and Toxicology, Wright State University Boonshoft School of Medicine, Dayton, OH, USA

4:45PM - 5:00PM | Questions and Answers


MONDAY, AUGUST 29, 2022

10:30 AM to 12:30 PM | Symposium 9: Cancer Genomics Provides Insight into Cancer Etiology, Progression and Therapeutic Response

Chairs: Barbara Parsons, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA, Jiri Zavadil, International Agency for Research on Cancer, Lyon, France, Kelly Harris, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA

Location: Confederation I - Level 4

10:30AM - 11:00AM | Hereditary Cancer Surveillance Using Circulating Tumour DNA sequencing
Trevor Pugh, Princess Margaret Cancer Centre, Toronto, ON, Canada. Ontario Institute for Cancer Research, Toronto, ON, Canada

11:00AM - 11:30AM | Chemical-induced Somatic Mutation Signatures Identified by Next-generation Sequencing
Shoji Matsumura, Kao Corporation, Kawasaki, Kanagawa, Japan

11:30AM - 12:00PM | Multi-omics Analysis in Experimental Models of Carcinogen-Mediated, Progressive Cell Transformation
Michael Korenjak, International Agency for Research on Cancer, Lyon, France

12:00PM - 12:30PM | Variation in Cancer Driver Mutation Levels as a Metric of Clonal Expansion for Cancer Risk Assessment
Barbara Parsons, US Food and Drug Administration, Jefferson, AR, USA


10:30 AM to 12:30 PM | Symposium 10: Consequences of Pharmaceuticals and Chemicals for Male and Female Germ Cell Heritability

Chairs: Jill Escher, Escher Fund for Autism, San Jose, CA, USA, Bernard Robaire, McGill University, Montreal, QC, Canada

Location: Confederation II - Level 4

10:30AM - 10:55AM | Paternally Mediated Developmental Toxicity
Bernard Robaire, McGill University, Montreal, QC, Canada

10:55AM - 11:20AM | Polycomb-Dependent Regulation of the Oocyte Epigenome and Its Impacts on Offspring
Patrick WesternHudson Institute of Medical Research and Monash University, Clayton, Vic, Australia

11:20AM - 11:45AM | Germline Exposure to Sevoflurane Results in Dysregulation of Brain-Related Genes in Offspring
Vesna Jevtovic-TodorovicUniversity of Colorado School of Medicine, Aurora, CO, USA

11:45AM - 12:10PM | General Anesthetics Induce Epigenetic Alterations in Germ Cells that Result in Autism-like Behaviors
Hsiao-Lin V. Wang, Emory University, Atlanta, GA, USA

12:10PM - 12:25PM | Effects of Intergenerational Arsenic Exposure on the Mouse Epigenome

Mathia L ColwellUniversity of Minnesota, St. Paul, MN, USA


10:30 AM to 12:30 PM | Symposium 11: Developing Integrated Approaches to Testing and Assessment (IATA) Using an Adverse Outcome Pathway (AOP) Framework

Chairs: Anax Oliveria, Lhasa Limited, Leeds, United Kingdom, Bette Meek, University of Ottawa, Ottawa, ON, Canada

Location: Confederation III - Level 4

10:30AM - 10:50AM | Activation Levels of MIE Transcriptional Biomarkers Identify Liver Tumorigenic Dose Levels
J Chris Corton, U.S. EPA, Research Triangle Park, NC, USA

10:50AM - 11:10AM | Update on the Ongoing OECD Validation of the ToxTracker Assay for Genotoxic Mode of Action Assessment
Giel Hendriks, Toxys, Oegstgeest, Netherlands

11:10AM - 11:30AM | Developing Integrated Approaches to Testing and Assessment (IATA) Using an Adverse Outcome Pathway (AOP) Framework
Anthony Lynch, GlaxoSmithKline R&D, Genetic Toxicology & Photosafety, Stevenage, Hertfordshire, United Kingdom

11:30AM - 11:50AM | Integration of Data with Adverse Outcome Pathways (AOPs) to Support Genotoxicity Assessment
Steven Kane, Lhasa Limited, Leeds, United Kingdom

11:50AM - 12:10PM | Practical Application of AOPs in Regulatory Risk Assessments
Dr. Crina Heghes, Lhasa Limited, Leeds, United Kingdom

12:10PM - 12:30PM | Q&A Session


10:30 AM to 12:30 PM | Symposium 12: How Cells Tolerate and Replicate DNA Damage?

Chairs: Carlos FM Menck, University of São Paulo, São Paulo, Brazil, Vanesa Gottifredi, Fundación Instituto Leloir, Buenos Aires, Argentina

Location: Governor General I/II - Level 4

10:30AM - 11:00AM | Does the Error-Prone DNA Polymerase eta Replicate Pyrimidine Dimers Correctly?
Carlos FM Menck, Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil

11:AM - 11:30AM | Revealing New Functions of the Translesion DNA Polymerase Zeta and the Consequences on Genome Stability
Patricia Kannouche, Goustave Roussy - CNRS, Villejuif, France

11:30AM - 12:00PM | Non-TLS (Translesion DNA Synthesis) Functions of TLS Polymerases
Vanesa Gottifredi, Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina

12:00PM - 12:15PM | The Essential Role of Oxidative Stress in Translesion Synthesis Deficient Human Patients Cells (XP-V)
Natália C Moreno, University of Sao Paulo (USP), Sao Paulo, SP, Brazil, National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA

12:15PM - 12:30PM | Time-Lapse Crystallography Reveals Hidden DNA Polymerase Lambda Fidelity Checkpoints

Joonas JamsenNIEHS, RTP, USA


TUESDAY, AUGUST 30, 2022

10:30 AM to 12:30 PM | Symposium 13: De Novo Germline Mutations and Environmental Mutagenesis

Chairs: Kenichi Masumura, Division of Genetics and Mutagenesis, National Institute of Health Sciences, Kanagawa, Japan, Jonatan Axelsson, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden, Mathia
Colwell, University of Minnesota, Minneapolis, MN, USA

Location: Confederation I - Level 4

10:30AM - 11:00AM | Mutagenicity in Germ Cells and De Novo Mutations in the Offspring
Kenichi Masumura, National Institute of Health Sciences, Kanagawa, Japan

11:00AM - 11:30AM | Analysis of De Novo Germline Mutations in DNA Repair-Deficient Mice Lines
Mizuki Ohno, Kyushu University Fukuoka, Fukuoka Japan

11:30AM - 12:00PM | Duplex Sequencing for Mutations in Blood and Spermatozoa from Young Men – A Pilot Study
Jonatan Axelsson, Reproductive Medicine Centre, Skåne University Hospital, Malmö, Sweden. Lund University, Lund, Sweden. University of Ottawa, Ottawa, ON, Canada

12:00PM - 12:15PM | Harnessing Genomic Technologies for Assessing Germ Cell Mutagenicity in Humans and Laboratory Models
Francesco Marchetti, PhD, Health Canada, Ottawa, ON, Canada

12:15PM - 12:30PM | Investigating the Connection Between Germline Mutation Rates, Age, and Male Fertility Using Duplex DNA Sequencing of Bulk Sperm
Jason KunisakiUniversity of Utah, Salt Lake City, UT, USA

10:30 AM to 12:30 PM | Symposium 14: Polynucleotide Signatures and Regulation of Genotoxin Stress Response

Chair:  Robert Sobol, PhD, Point Clear Charities Professor, Department of Pharmacology Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA

New Investigator Co-Chairs: Ryan Barnes, PhD, University of Pittsburgh, Pittsburgh, PA, USA, Aishwarya Prakash, PhD, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA, Bret D. Freudenthal, PhD, University of Kansas, Kansas City, KS, USA

Location: Confederation II - Level 4

10:30AM - 11:00AM | Functions of the DNA Repair Polymerase POLq in Processing ssDNA Gaps and Promoting Replication Fork Progression

Joanna Loizou, PhD, Comprehensive Cancer Centre, Medical University of ViennaVienna, Austria 

11:00AM - 11:15AM | PARP1 Association to R-Loops Triggers Its Acitivity

Elise Fouquerel, PhD University of Pittsburgh, Pittsburgh, PA, USA

11:15AM - 11:45AM | RNA-mediated DNA Double Strand Break Repair 
Youngkyu JeonGeorgia Institute of Technology, GA, USA

High-Throughput Transcriptomics and Chemical Toxicity Testing: Quality Control Approaches to Enhance Consistency and Reproducibility

Matthew J MeierHealth Canada, Ottawa, Ontario, Canada

12:00PM - 12:30PM | Poly-ADP-ribose in the Regulation of DNA Repair and the Cellular Response to Genotoxins
Robert Sobol, PhD, University of South Alabama, Mobile, AL, USA


10:30 AM to 12:30 PM | Symposium 15: New Approaches for Informing Population Variability in Chemical Risk Assessment

Chairs: Catherine Gibbons, US EPA, Washington, D.C., VA, USA, Michael Stewart, US EPA, Washington, D.C., VA, USA, Chelsea Weitekamp, US EPA, Washington, D.C., VA, USA

Location: Confederation III - Level 4

10:30AM - 11:00AM | New Approaches in Cancer Risk Assessment: Why study design matters
Mary Beth Terry, Columbia, New York, NY, USA

11:00AM - 11:30AM | Application of Bayesian and Probabilistic approaches for Cancer Dose-Response Assessment incorporating Model Uncertainty and Human Variability
Weihsueh A Chiu, Texas A&M University, College Station, TX, USA

11:30AM - 12:00PM | Approaches to Addressing Population Variability at CalEPA/OEHHA
Vincent James Cogliano, CalEPA Office of Environmental Health Hazard Assessment, Oakland, CA, USA

12:00PM - 12:15PM | Variation in Blood Lead (Pb) Accumulation Is Strongly Influenced by Genetics

Danila CuomoTexas A&M University, College Station, TX, USA

12:15PM - 12:30PM | A Toxic Aging Coin: Case for Cr(VI) Neurotoxicity and Gerontogenicity

John P Wise, Jr.University of Louisville, Louisville, KY, USA


10:30 AM to 12:20 PM | Symposium 16: From Genomes to Ecosystems: What Are the Ecological Consequences of Genotoxicity?

Chairs: Jason O'Brien, Environment and Climate Change Canada, Ottawa, ON, Canada, Gisela de Aragão Umbuzeiro, Universidade Estadual de Campinas, Campinas, Brazil, Awadhesh Jha, University of Plymouth, Plymouth, United Kingdom, Helina Gyasi, University of Ottawa, Ottawa, ON, Canada

Location: Governor General III - Level 4

10:30AM - 11:00AM | From Molecules to Ecosystems: An AOP-Based Perspective on the Current Status of the Field of Ecogenotoxicology
Jason M. O'Brien, Environment and Climate Change Canada, Ottawa, ON, Canada

11:00AM - 11:30AM | An Integrated Approach to Assess the Impact of Emerging Contaminants on Aquatic Organisms
Awadhesh N Jha, University of Plymouth, Plymouth, Devon, United Kingdom

11:30AM - 12:00PM | Ecogenotoxicological Effects Related to Coal Mining and Burning
Juliana da Silva, Universidade La Salle, Canoas, RS, Brazil

12:00PM - 12:15PM | Knowing the Resistance: 'Omics for Screening and Understanding the Impacts of Insecticide Resistance in Non-Target Species
Helen Poynton, University of Massachusetts, Boston, MA, USA

12:15PM - 12:30PM | Investigating the Mutagenicity of Polycyclic Aromatic Compounds from the Athabasca Oil Sands Region in River Otters and a Mammalian Cell Line
Helina Gyasi, University of Ottawa, Ottawa, ON, Canada


10:30 AM to 12:30 PM | Symposium 17: New Tools in Carcinogenicity Testing

Sponsored by: Inotiv

Chairs: Patricia Escobar, Merck & Co. Inc., West Point, NY, USA, Barbara Parsons, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA, Xilin "Shan" Li, National Center for Toxicological Research, Jefferson, AR, USA

Location: Governor General I/II - Level 4

10:30AM - 10:55AM | A Weight-of-Evidence Approach for Assessing Human Carcinogenic Risk of Small Molecule Pharmaceuticals that Reduces Reliance on Conventional Rodent Carcinogenicity Studies: An Overview of the ICH S1B(R1) Addendum
Patricia A. Escobar, Merck & Co. Inc., West Point, PA, USA

10:55AM - 11:20AM | Toxicogenomics in Carcinogenic Risk Assessment
Heidrun Ellinger-Zeigelbauer,  Bayer AG, Wuppertal, NRW, Germany

11:20AM - 11:45AM | Duplex Sequencing for Quantitative Detection of Clonal Expansions for the in vivo Assessment of Nongenotoxic Carcinogens
Keith Tannis, Merck & Co, West Point, PA, USA

11:45AM - 12:10PM | Relationship Between Cancer Driver Mutational Based Biomarkers and Tissue-specific Tumor Susceptibility in Rodents
Kelly Harris, US Food & Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA

12:10PM - 12:25PM | Duplex Sequencing Reveals Variability in Mutation Susceptibility Across the Genome and an Attenuated Response in the Germ Cells of MutaMouse Males Exposed to Benzo[a]pyrene Relative to the TGR LacZ Assay

Danielle LeBlancEnvironmental Health and Radiation Sciences Bureau, Health Canada, Ottawa, ON, Canada


3 PM to 5 PM | Symposium 18: Personalized Cancer Risk and Prevention: Models Integrating Genetics, Environmental Exposures, Infections, Diet, and Other Factors for Specific Cancers

Chairs: Rosalie Lijinsky, Silver Spring, MD, USA, Jonatan Axelsson, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden, Clarissa Ribeiro Reily Rocha, Departamento de Microbiologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP, Brazil

Location: Confederation I - Level 4

3:00PM - 3:30PM | Integration of Risk Factors for Specific Cancers into a Cancer Risk Assessment Paradigm for Medical Devices

Rosalie K ElespuruUS Food and Drug Administration, Silver Spring, MD, USA

3:30PM - 4:00PM | Colorectal Cancer Risk Factors and their Potential for Precision Prevention
Mingyang Song, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

4:00PM - 4:30PM | Risk Prediction of Gastric Cancer in Asian Populations: Its Potential Application to Personalized Prevention and Screening
Shoichiro Tsugane, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan

4:30PM - 4:45PM | Prolonged Exposure to Particulate Hexavalent Chromium Induces Inhibition of RAD51 and Increased Chromosome Instability in Human Bronchial Epithelial Cells

Idoia MeazaUniversity of Louisville, Louisville, KY, USA

4:45PM - 5:00PM | DNA Damage and Mutation Hotspots Caused by Aquaporin 3 and its Interaction with Low-Dose Arsenic—Potential Roles in Lung Cancer Evolution

Jun XiaCreighton University, Omaha, NE, USA. Baylor College of Medicine, Houston, TX, USA


3 PM to 5 PM | Symposium 19: Novel Experimental Strategies for Investigating the Incidence and Mechanisms of Mutations

Chairs:  Steve Rozen, Duke-NUS Centre for Computational Biology, Duke-NUS Medical School, Singapore, Singapore, Bevin Engelward Sc.D., Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA

Location: Confederation II - Level 4

3:00PM - 3:10PM | Opening Statement
Bevin Engelward Sc.D., Department of Biological Engineering Massachusetts Institute of Technology, Cambridge, MA, USA, Steve Rozen, Duke-NUS Centre for Computational Biology, Duke-NUS Medical School, Singapore, Singapore 

3:10PM - 3:32PM | Experimental Delineation of Mutational Signatures
Jiri Zavadil, International Agency for Research on Cancer, WHO, Lyon, Rhône-Alpes, France

3:32PM - 3:54PM | Using Normal Human Tissue-Derived Organoids to Identify Mutational Signatures of Environmental and Chemotherapeutic Agents
Jill E. Kucab, King’s College London, London, United Kingdom

3:54PM - 4:16PM | Opportunities and Challenges in Using Mutational Signature Analysis to Illuminate Cancer Biology and Epidemiology
Steven G Rozen, Duke-NUS Medical School, Singapore, Singapore

4:16PM - 4:38PM | DNA Damage and Repair Processes Shape Mutational Signatures

Joanna Loizou, Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria

4:38PM - 5:00PM | Application of Mutational Signatures of Carcinogens as Biomarkers of Cancer
Bogdan I. Fedeles, Massachusetts Institute of Technology, Cambridge, MA, USA


3 PM to 5 PM | Symposium 20: Risk Assessment of Low-Dose Rate Radiations, Lessons from the Fukushima Nuclear Accident

Chairs: Takayoshi Suzuki, National Institute of Health Sciences, Kawasaki, Japan, Yoshihisa Matsumoto, Tokyo Institute of Technology, Tokyo, Japan

Location: Confederation III - Level 4

3:00PM - 3:15PM | Fukushima Daiichi Nuclear Power Station Accident from the Aspect of Radiation Biology and Risk Communication
Yoshihisa Matsumoto, Tokyo Institute of Technology, Tokyo, Japan

3:15PM - 3:45PM | Long-term Strategies for Thyroid Health Monitoring After Nuclear Accidents: Recommendations from an Expert Group Convened by IARC
Kayo Togawa, International Agency for Research on Cancer, Lyon, France

3:45PM - 4:15PM | Evaluation of Biological and Health Effects in Response to Chronic Low Dose Radiation on Human Population: Current Scenario in High Background Radiation Areas of Kerala, India
Birajalaxmi Das, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India

4:15PM - 4:45PM | Experimental Studies on the Biological Effects of Chronic Low Dose-Rate Radiation Exposures in Mice
Ignacia lll B. Tanaka, Institute for Environmental Sciences, Rokkasho, Aomori, Japan

4:45PM - 5:00PM | Workshop Report: Fundamentals of Benchmark Dose Modeling and Application to Support Areas in the Radiation Field
Ngoc Q Vuong, Health Canada, Ottawa, ON, Canada


3 PM to 5 PM | Symposium 21: Role of RNA in DNA Repair

Chairs: Mats Ljungman, University of Michigan, Ann Arbor, MI, USA, Heather O'Hagan, University of Indiana, Bloomington, IN, USA

Location: Governor General I/II - Level 4

3:00PM - 3:15PM | Transcription for Genome Integrity
Mats Ljungman, University of Michigan, Ann Arbor, MI, USA

3:15PM - 3:45PM | Nucleotide Excision Repair Controls RNA Polymerase II levels
Manuel J. Muñoz, IFIBYNE, Buenos Aires, Argentina

3:45PM - 4:15PM | Molecular Mechanisms in Transcription-Coupled DNA Repair
Martijn S Luijsterburg, Leiden University Medical Center, Leiden, Netherlands

4:15PM - 4:45PM | DROSHA and DICER RNA Products Control PRC1-Dependent Transcriptional Repression at DNA Damage Sites
Sofia Francia, Istituto di Genetica Molecolare, Pavia, Italy

4:45PM - 5:00PM | Transcription-Coupled DNA Repair of Cytotoxic Alkylation Damage

Peng MaoUniversity of New Mexico, Albuquerque, NM, USA

THURSDAY, SEPTEMBER 1, 2022

10:30 AM to 12:30 PM | Symposium 22: Dynamics of Mutation Acquisition in Somatic Cells: SNVs and SVs in the Brain, Blood and Beyond

Chairs: Thomas Wilson, University of Michigan, Ann Arbor, MI, USA, Thomas Glover, University of Michigan, Ann Arbor, MI, USA, Natalie Saini, Medical University of South Carolina, Charleston, SC, USA

Location: Confederation I - Level 4

10:30AM - 10:55AM | Interrogating the Architecture of Cancer Genomes
Peter Campbell, Wellcome Sanger Institute, Hinxton, Cambs, United Kingdom

10:55AM - 11:20AM | Single Cell Sequencing Reveals New Insights into Genomic Structural Variation
Jan O Korbel, European Molecular Biology Laboratory, Heidelberg, Germany. German Cancer Research Center, Heidelberg, Germany

11:20AM - 11:45AM | Recurrent Somatic Mutations in Human Neurons
Michael J. McConnell, Lieber Institute for Brain Development, Baltimore, MD, USA

11:45AM - 12:10PM | Implications of DNA Double-Strand Break Formation and Repair for Neural Progenitors and Mature Neurons
Bjoern Schwer, University of California, San Francisco, CA, USA

12:10PM - 12:2PM | Neurodegeneration-Associated TDP-43 Regulates Expression of Key DNA Mismatch Repair (MMR) Genes with Implications to Mutator Phenotype in Neurons
Vincent E Provasek, Texas A&M University, College Station, TX, USA. Houston Methodist Research Institute, Houston, TX, USA


10:30 AM to 12:30 PM | Symposium 23: Managing Genes in Space

Chairs: William Kaufmann, Past-President of EMGS, Durham, NC, USA, Tatiana Kozbenko, University of Ottawa, Ottawa, ON, CanadaHealth Canada, Ottawa, ON, Canada

Location: Confederation II - Level 4

10:30AM - 11:00AM | New Insights into the Effects of Space Radiation on the Brain
Janet E. Baulch, University of California Irvine, Irvine, CA, USA

11:00AM - 11:15AM | Effects of Simulated Microgravity on Mammary Cells in 2 and 3 D Tissue Architecture
Janice M. Pluth, University of Nevada Las Vegas, Las Vegas, NV, USA

11:15AM - 11:45AM | Effects of Galactic Cosmic Rays and Other Environmental Factors in Space on the Cardiovascular System
Marjan Boerma, University of Arkansas for Medical Sciences, Little Rock, AR, USA

11:45AM - 12:00PM | The Adverse Outcome Pathway Approach to Define Mechanisms of Vascular Remodeling Resulting from Space Exposure

Tatiana KozbenkoHealth Canada, Ottawa, ON, Canada. University of Ottawa, Ottawa, ON, Canada

12:00PM - 12:30PM | Individual Susceptible to Cancer from Space Radiation Exposure
Michael M. Weil, Colorado State University, Fort Collins, CO, USA


10:30 AM to 12:30 PM | Symposium 24: Using Quantitative Genetic Toxicology to Advance the Assessment of Genotoxic Impurities in Pharmaceuticals

Chairs: George Johnson, Swansea University, Swansea, United Kingdom, Andreas Zeller, Hoffman La Roche, Basel, Switzerland

Location: Confederation III - Level 4

10:30AM - 11:00AM | Quantitative Analysis of In Vivo Mutagenicity Dose Response Data for Risk Assessment and Regulatory Decision-making: A Case Study of Nitrosamines
George Johnson, Swansea University, Swansea, United Kingdom

11:00AM - 11:30AM | NDMA Induced Genotoxicity in the Low Dose Region in Muta™Mouse
Anthony M Lynch, GSK, Stevenage, Herts, United Kingdom

11:30AM - 12:00PM | Current Regulatory Risk Assessment Procedure and Regulatory Concerns with Using Quantitative Genetic Tox Data for Risk Assessment
Roland Froetschl, BfArM - Federal Institute for Drugs and Medical Devices, Bonn, Germany

12:00PM - 12:30PM | Nitrite Levels in Common Excipients, Impact on Nitrosamine Risk Assessment

Grace J KocksLhasa Limited, Leeds, United Kingdom


10:30 AM to 12:30 PM | Symposium 25: R-loop Roadblocks to Transcription and Replication

Chairs: Philip Hanawalt, Department of Biology, Stanford University, Stanford, CA, USA, Andrés Aguilera, Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Seville, Spain, Yesenia Rodriguez, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA

Location: Governor General I/II - Level 4

10:30AM - 11:00AM | Chromatin Modifications Upon Transcription-Dependent or Independent Replication Stress
Andrés Aguilera, Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Seville, Spain.

11:00AM - 11:30AM | Investigating the Mechanisms Behind R-Loop Induced Lethality Upon Replication-Transcription Conflicts
Houra Merrikh, Vanderbilt University, Nashville, TN, USA

11:30AM - 12:00PM | Toxic R-loops as a Cause and Consequence of Replication Stress
Philippe PaseroInstitut de Génétique Humaine, CNRS and Université de Montpellier, Montpellier, France

12:00PM - 12:15PM | The Multifaceted Roles of Base Excision Repair Enzymes in DNA Repair and R-loop Homeostasis
Yesenia Rodriguez, National Institute of Environmental Health Sciences, Durham, NC, USA

12:15PM -12:30PM | Perspectives on the Processing of R-loops by Nucleotide Excision Repair
Philip HanawaltDepartment of Biology, Stanford University, Stanford, CA, USA
(A short summary with references of recent research from Karlene Cimprich on Mechanisms for RNA-mediated Genome Instability)


1:30 PM to 3:30 PM | Symposium 26: Genome Editing: Intentional Mutagenesis of the Genome and Implications for Human Health

Chair: P.J. Brooks, NCATS, NIH, Bethesda, MD, USA

Location: Confederation I - Level 4

1:30PM - 2:00PM | Understanding Human Genetic Variation with Precision Genome Editing Tools
Alexis C KomorUniversity of California, San Diego, La Jolla, CA, USA

2:00PM - 2:30PM | Profiling Cell Type Specificity and Adverse Events of Genome Editing Nucleases in the Brain and Retina Using Single Cell Transcriptomics
Krishanu SahaUniversity of Wisconsin - Madison, Madison, WI, USA

2:30PM - 2:45PM | Low Frequency Somatic Copy Number Alterations in Normal Human Lymphocytes Revealed by Large Scale Single-Cell Whole Genome Profiling

Yusi FuCreighton University, Omaha, NE, USA

2:45PM - 3:00PM | Designed Synthesis of Translocations and Induction of Chromosomal Aberrations by Genome Editing

Takayoshi SuzukiNational Institute of Health Sciences, Kawasaki, Kanagawa, Japan


1:30 PM to 3:30 PM | Symposium 27: International Workshop on Genotoxicity Testing: Summary of Consensus Statements

Chairs: Hans-Joerg Martus, Novartis, Basel, Switzerland, David Kirkland, Kirkland Consulting, Tadcaster, United Kingdom, Andreas Zeller, Hoffmann La-Roche, Basel, Switzerland 

Location: Confederation II - Level 4

1:30PM - 1:47PM | Transcriptomic Biomarkers
Roland Froetschl, Federal Institute for Drugs and Medical Devices, Bonn, Germany

1:47PM - 2:04PM | Predictivity of In Vitro Genotoxicity Testing, a Mathematical Modelling Approach
Mirjam Luijten, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands

2:04PM - 2:21PM | Genotoxicity Dose-response Analysis for Potency Comparisons and Risk Assessment
Paul White, Health Canada, Ottawa, Canada

2:21PM - 2:38PM | In Vivo Strategies
Carol Beevers, Broughton-Group, Earby, Lancashire, United Kingdom

2:38PM - 2:55PM | Statistical Approaches and Data Interpretation
Stephen Dertinger, Litron Laboratories, Rochester, New York, USA

2:55PM - 3:12PM | Epigenotoxicity and Germ Cell Effects
Roger Godschalk, Maastricht University, Maastricht, Netherlands

3:12PM - 3:30PM | Gene Therapy
Silvana Libertini, Novartis Institutes for BioMedical Research, Basel, Switzerland


1:30 PM to 3:30 PM | Symposium 28: Carcinogens, Carcinogenesis and Cancer: Application of Artificial Intelligence and Machine Learning

Chairs: Luoping Zhang, School of Public Health, University of California, Berkeley, CA, USA, Maria Zhivagui, Department of Cellular and Molecular Medicine, University of California, San Diego, CA, USA

Location: Confederation III - Level 4

1:30PM - 2:00PM | How AI Can Beat Animal Testing at Finding Toxic Chemicals as Potential Carcinogens
Thomas Hartung, Johns Hopkins University, Baltimore, MD, USA

2:00PM - 2:15PM | Predicting the Binding of Small Molecules to Nuclear Receptors Using Machine Learning and Molecular Modeling Techniques
Azhagiya Singam Ettayapuram Ramaprasad, University of California - Berkeley, Berkeley, CA, USA

2:15PM - 2:30PM | Benchmarking Indel Detection Methods for Oncopanel Sequencing Data Through a PrecisionFDA Bioinformatics Challenge
Joshua Xu, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA

2:30PM - 3:00PM | COSMIC eSignatures: A collection of experimentally derived mutational signatures due to environmental agents
Maria Zhivagui, University of California San Diego, La Jolla, CA, USA

3:00PM - 3:30PM | A Multi-omic Approach and Bioinformatic Analysis of Exposures to Chemical Carcinogens
Luoping Zhang, University of California at Berkeley, Berkeley, CA, USA


1:30 PM to 3:30 PM | Symposium 29: Approaches for Studies of DNA Damage and Repair with Applications in Human Biomonitoring and Disease Risk Prediction

Chairs: Andrew Collins, University of Oslo, Oslo, Norway, Bevin Engelward, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA, Sabine Langie, Maastricht University, Maastricht, Netherlands

Location: Governor General III - Level 4

1:30 PM - 2:00PM | The Comet Assay; Past Success and Future Promise
Andrew Collins, University of Oslo, Oslo, Norway 

2:00PM - 2:30PM | Measuring Nucleotide Excision Repair Capacity to Identify Disease Risk
Laura J Neidernhoffer, University of Minnesota Medical School, Minneapolis, MN, USA

2:30PM - 3:00PM | Studying Nutritional Modulation of DNA Repair: The Value of the Comet Based in Vitro DNA Repair Assay

Sabine Langie, Department of Pharmacology & Toxicology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, Netherlands 

3:00PM - 3:15PM | Use of the CometChip for Public Health and Molecular Epidemiology
Bevin Engelward, Massachusetts Institute of Technology, Cambridge, MA, USA

3:15PM - 3:30PM | Assessing Testicular Germ Cell DNA Damage in the Comet Assay; Introduction of a Proof-Of-Concept

Ann Karin OlsenNorwegian Institute of Public Health, Division of Climate and Environmental Health, Oslo, Norway. Centre for Environmental Radioactivity (CERAD, Centre of Excellence of the Norwegian Research Council), Oslo, Norway


1:30 PM to 3:30 PM | Symposium 30: Mutagenic Hazards of PAHs and PAH Mixtures

Chairs: Yasunobu Aoki, National Institute for Environmental Studies, Tsukuba, Japan, Jennifer Keir, University of Ottawa, Ottawa, ON, Canada

Location: Governor General I/II - Level 4

1:30PM - 2:00PM | Genotoxic Effect of Polycyclic Aromatic Hydrocarbons Alone or in Mixture in Human Cells
Marc Audebert, INRAE, Toulouse, France

2:00PM - 2:30PM | Polycyclic Aromatic Compound Mixtures Research to Inform Component-based Risk Assessment
Cynthia Rider, NIEHS, Research Triangle Park, NC, USA

2:30PM - 3:00PM | In Vivo Mutagenesis of PAHs and Related Compounds Contained in Airborne Particles
Yasunobu Aoki, National Institute for Environmental Studies, Tsukuba, Japan

3:00PM - 3:15PM | Biomonitoring Studies of Exposure to Airport Emissions, Diesel Exhaust and Firefighting
Anne T Saber, National Research Centre for the Working Environment, Copenhagen, Denmark

3:15PM - 3:30PM | Firefighters’ Combustion-derived PAH Exposures and Investigating Exposure Reduction Methods
Jennifer Keir, University of Ottawa, Ottawa, ON, Canada