13th International Conference on Environmental Mutagens
Maintaining Genomic Health in a Changing World
53rd Annual Meeting of the EMGS
August 27 - September 1, 2022 - Ottawa Canada
ICEM 2022 Sponsors
Become a Sponsor
Diamond Level:
Morningside Foundation
NIEHS R13 Grant No. 5R13ES031435-03
TwinStrand Biosciences
Platinum Level:
Escher Fund for Autism
Health and Environmental Sciences Institute
Proctor & Gamble, Co.
US-FDA R13 Grant No. 5R13FD006702-04
University of Ottawa
MGI Americas Inc.
Carleton University
Gold Level:
Bristol Myers Squibb
Canadian Institutes for Health Research
Inotiv Inc.
Silver Level:
Burroughs Wellcome Fund
Elsevier
United Kingdom Environmental Mutagen Society
Gilead Sciences
National Cancer Institute (NCI)
Merck Research
Bronze Level:
Lhasa Limited
The Research Institute for Fragrance Materials
Moltox, Molecular Toxicology, Inc.
BASF Corp.
Toxys B.V.
Litron Laboratories
Instem
Kao Corporation
MultiCASE
Supporter
Mutagen-Brasil
Johnson & Johnson
University of Michigan
John J. Nicolette, MS, DABT
Contributors
European Environmental Mutagenesis and Genomics Society
Japanese Environmental Mutagen and Genome Society
Journal of Biochemistry
Illumina
Pfizer Inc.
Environmental and Molecular Mutagenesis Journal
Bill Kaufmann, PhD
Genetic Toxicology Association
Society of Toxicology
SYMPOSIA
A total of 30 symposia are included in the main program of the meeting. Symposia are an equal balance of applied and basic science spanning the specialty areas and are summarized below:
SUNDAY, AUGUST 28, 2022
10:30 AM to 12:30 PM | Symposium 1: Advancing Mechanistic Analyses in Genetic Toxicology Using High-Content and High-Throughout Methodologies
Sponsored by: 
Chairs: Alexandra Long, Health Canada, Ottawa, Canada, Dan Roberts, Charles River Laboratories, Skokie, IL, USA, Eunnara Cho, Carleton University, Ottawa, Canada
Location: Confederation I - Level 4
10:30AM - 11:00AM | Evaluating Cellular Responses to Toxic Compounds by High Content Screening
David Andrews, Sunnybrook Research Institute & University of Toronto, Toronto, ON, Canada
Paul Rees, Swansea University, Swansea, United Kingdom
Steve Bryce Litron Laboratories, Rochester, NY, USA
Bevin Page Engelward, Massachusetts Institute of Technology, Cambridge, MA, USA
Carole L Yauk, University of Ottawa, Ottawa, ON, Canada
12:00PM - 12:15PM | GeneTox21- An Integrated Platform for In Vitro Genetic Toxicity Assessment and Regulatory Evaluation of New and Existing Substances
Hannah Battaion, Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada
12:15PM - 12:30PM | High-Content Imaging and Deep Learning: Opportunities and Challenges in Toxicology
John Wills, University of Cambridge, Cambridge, United Kingdom
10:30 AM to 12:30 PM | Symposium 2: The Graham Walker Symposium: Complexity of Cellular Responses to DNA Damage
Sponsored by: 
Chairs: Iain Lambert & Bruce McKay, Carleton University, Ottawa, ON, Canada
Location: Governor General I/II - Level 4
10:30AM - 11:00AM | RNA-DNA Hybrids Cause Genome-Wide Instability Through Nucleobase Deamination and Genomic Rearrangements in Bacteria
Lyle Simmons, University of Michigan, Ann Arbor, MI, USA
11:00AM - 11:30AM | Insights into How Bacteria Manage the Actions of Their DNA Polymerases
Mark Sutton, University at Buffalo, SUNY, Buffalo, NY, USA
11:30AM - 12:00PM | Translesion synthesis: From Cancer Resistance to Host-Pathogen Interactions
Nimrat Chatterjee M.Sc. Ph.D, The Larner College of Medicine at The University of Vermont, Burlington, VT, USA
Marcela Teatin Latancia, Biomedical Science Institution - University of Sao Paulo, Sao Paulo, SP, Brazil
12:15PM - 12:30PM | Concluding Remarks
Graham Walker, Massachusetts Institute of Technology, Cambridge, MA, USA
10:30 AM to 12:30 PM | Symposium 3: Application of Computational Modeling and Bioinformatics in Toxicological Hazard and Risk Assessment
Chairs: Julia Rager, UNC-Chapel Hill, NC, USA; Marc Beal, Health Canada, ON, Canada; Scott Auerbach, NIEHS, Durham, NC, USA
Location: Confederation III - Level 4
10:30AM - 11:00AM | Systems Biology: Systematic Data Integration and Modeling for Toxicological Inference
Olivier Thierry Taboureau, University of Copenhagen, Copenhagen, Denmark
11:00AM - 11:30AM | Application of Artificial Intelligence in Toxicology
Weida Tong, US Food and Drug Administration, Silver Spring, MD, USA
11:30AM - 12:00PM | Applications of Literature Mining and Natural Language Processing to Evidence Mapping and Systematic Review
Daniele Wikoff, ToxStrategies, Inc., Asheville, NC, USA
12:00PM - 12:15PM | Genomic Dose Response: Modeling in Chemical Risk Assessment
Scott Auerbach, NIEHS, NTP, NC, USA
K. Nadira De Abrew, The Procter & Gamble Company, Cincinnati, OH, USA
10:30 AM to 12:30 PM | Symposium 4: Analyses of DNA Modifications and Their Roles in Human Carcinogenesis
Sponsored by: 
Chairs: Haruhiko Sugimura, Hamamatsu University School of Medicine, Hamamatsu, Japan, Silvia Balbo, University of Minnesota, Minneapolis, MN, USA
Location: Confederation II - Level 4
10:30AM - 11:00AM | Human Adductomics, Challenges
Haruhiko Sugimura, Hamamatsu University School of Medicine, Hamamatsu, Japan
11:00AM - 11:30AM | Untargeted DNA Adductomics
Silvia Balbo, Masonic Cancer Center, Minneapolis, MN, USA
11:30AM - 12:00PM | An Experimental Tool-Box for Quantifying DNA Damage and Epigenetic Transformations
Yuval Ebenstein, School of Chemistry, Tel Aviv University, Tel Aviv, Israel
Peter W Villalta, University of Minnesota, Masonic Cancer Center, Department of Medicinal Chemistry, Minneapolis, MN, USA
Mia Petljak, Broad Institute of MIT and Harvard, Cambridge, MA, USA
3 PM to 5 PM | Symposium 5: Genotoxic Hazards of Air Pollution – A Global Perspective
Chairs: Paul A. White, Health Canada, Ottawa, ON, Canada, Gisela de Aragão Umbuzeiro, State University of Campinas, Campinas, Brazil, David DeMarini, University of North Carolina, Chapel Hill, NC, USA
Location: Confederation I - Level 4
3:00PM - 3:30PM | IARC Evaluation of Air Pollution Carcinogenicity: Supporting Mechanistic Evidence
Paul White, Health Canada, Ottawa, ON, Canada
3:30PM - 4:00PM | Mutagenicity and Carcinogenicity of the Gas Phase and Particulate Components of Polluted Air
David DeMarini, (Retired), U.S. Environmental Protection Agency, Research Triangle Park, NC, USA
4:00PM - 4:30PM | Comparative Mutagenicity of Airborne Particulate Matter from Three Continents
Gisela Aragão Umbuzeiro, UNICAMP, LIMEIRA, Sao Paulo, Brazil
4:30PM - 4:45PM | Mutagenic Hazards of Air Pollution in Asia
Kazuichi Hayakawa, Kanazawa University, Nomi, Ishikawa, Japan
4:45PM - 5:00PM | Particulate Matter in North-West Italy During the COVID-19 Pandemic: Biological Effects.
Tiziana Schilirò, Department of Public Health and Pediatrics, University of Torino, Torino, Italy
3 PM to 5 PM | Symposium 6: In Vitro Screening Approaches for Risk Assessment
Chairs: Olivier Taboureau, Université de Paris, Paris, France, Xiaoqing (Carol) Guo, National Center for Toxicological Research, FDA, Jefferson, AR, USA
Location: Confederation II - Level 4
3:00PM - 3:30PM | High-throughput Molecular Profiling Assays and Potential Applications in Chemical Risk Assessment
Joshua Harrill, U.S. Environmental Protection Agency, Durham, NC, USA
3:30PM - 4:00PM | Using In Vitro to In Vivo Extrapolation (IVIVE) to Apply Genetic Toxicity Data to Regulatory Risk Assessment
Marc Beal, Health Canada, Ottawa, ON, Canada
4:00PM - 4:15PM | How In Vitro 3D Tissue Models can be Utilized in the Assessment of Genotoxicity Risk
Stefan Pfuhler, Procter & Gamble, Cincinnati, OH, USA
4:15PM - 4:30PM | Improving the Utility of In Vitro Screening Through Combined In Silico Modeling to Better Predict and Test Health Risks of Environmental Chemicals
Julia Rager, University of North Carolina, Chapel Hill, NC, USA
4:30PM - 5:00PM | Genotoxicity Assessment of Nanomaterials in Advanced Liver and Lung Models
Elisabeth Elje, NILU - Norwegian Institute for Air Research, Kjeller, Norway, University of Oslo, Oslo, Norway
3 PM to 5 PM | Symposium 7: Impact of Obesity on DNA Stability and its Health Consequences
Chairs: Siegfried Knasmueller, Institute of Cancer Research, Medical University Vienna, Vienna, Austria, Helga Stopper, Institute of Pharmacology and Toxicology, University of Wuerzburg, Wuerzburg, Germany, Vanessa Moraes de Andrade, Laboratorio de Immunologia e Mutagenese, UNESC, Santa Catarina, Brazil
Location: Confederation III - Level 4
3:00PM - 3:30PM | Obesity and DNA Damage – an Overview
Siegfried Knasmueller, Center for Cancer Research, Medical University of Vienna, Vienna, Austria
3:30PM - 4:00PM | Impact of Obesity on Cancer-Associated Mutation Hotspots
Karen Vasquez, University of Texas at Austin, Austin, TX, USA
4:00PM - 4:15PM | Prevention of Obesity Induced DNA Damage by Dietary Antioxidants in Mice
Vanessa Moraes de Andrade, Laboratory of Translational Biomedicine, Graduate Program of Health Sciences, University of Southern Santa Catarina – UNESC, Criciúma, Santa Catarina, Brazil
4:15PM - 4:45PM | Reduction of Genomic Damage by Weight Loss
Helga Stopper, University of Wuerzburg, Wuerzburg, Bavaria Germany
4:45PM - 5:00PM | Association Between Dietary Interventions and the Dynamics of Telomere DNA Repair: Implications for Obesity Related Disorders
Prakash Hande, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
3 PM to 5 PM | Symposium 8: DNA Cross-Link Repair and Health
Chairs: Sara Frias, Instituto de Investigaciones Biomédicas, UNAM/Instituto Nacional de Pediatría, Mexico City, Mexico, Alfredo Rodríguez, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico
Location: Governor General I/II - Level 4
3:00PM - 3:05PM | Presentation of the Participants' CV Summaries
Sara Frias, PhD, and Dr. Alfredo Rodríguez, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, México
3:05PM - 3:20PM | The FA/BRCA Pathway; Cellular and Clinical Consequences of Its Failure
Sara Frias, Instituto de Investigaciones Biomédicas UNAM, Instituto Nacional Pediatria, Ciudad de México, México
3:20PM - 3:45PM | Fanconi Anemia: From DNA Interstrand Crosslink Repair to Novel Therapies
Jordi Surrallés, Sant Pau Institute Research Institute, IIB Sant Pau, Barcelona, Spain, Barcelona, Spain
3:45PM - 4:10PM | Cell Fate Decisions in Fanconi Anemia Cells in the Face of DNA Damage
Alfredo Rodríguez Gómez, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico
4:10PM - 4:35PM | Ovarian Cancer as a Disease of DNA Repair
Liisa Kauppi, University of Helsinki, Helsinki, Finland
M Alexandra Carpenter, Department of Pharmacology and Toxicology, Wright State University Boonshoft School of Medicine, Dayton, OH, USA
4:45PM - 5:00PM | Questions and Answers
MONDAY, AUGUST 29, 2022
10:30 AM to 12:30 PM | Symposium 9: Cancer Genomics Provides Insight into Cancer Etiology, Progression and Therapeutic Response
Chairs: Barbara Parsons, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA, Jiri Zavadil, International Agency for Research on Cancer, Lyon, France, Kelly Harris, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA
Location: Confederation I - Level 4
10:30AM - 11:00AM | Hereditary Cancer Surveillance Using Circulating Tumour DNA sequencing
Trevor Pugh, Princess Margaret Cancer Centre, Toronto, ON, Canada. Ontario Institute for Cancer Research, Toronto, ON, Canada
11:00AM - 11:30AM | Chemical-induced Somatic Mutation Signatures Identified by Next-generation Sequencing
Shoji Matsumura, Kao Corporation, Kawasaki, Kanagawa, Japan
11:30AM - 12:00PM | Multi-omics Analysis in Experimental Models of Carcinogen-Mediated, Progressive Cell Transformation
Michael Korenjak, International Agency for Research on Cancer, Lyon, France
12:00PM - 12:30PM | Variation in Cancer Driver Mutation Levels as a Metric of Clonal Expansion for Cancer Risk Assessment
Barbara Parsons, US Food and Drug Administration, Jefferson, AR, USA
10:30 AM to 12:30 PM | Symposium 10: Consequences of Pharmaceuticals and Chemicals for Male and Female Germ Cell Heritability
Chairs: Jill Escher, Escher Fund for Autism, San Jose, CA, USA, Bernard Robaire, McGill University, Montreal, QC, Canada
Location: Confederation II - Level 4
10:30AM - 10:55AM | Paternally Mediated Developmental Toxicity
Bernard Robaire, McGill University, Montreal, QC, Canada
10:55AM - 11:20AM | Polycomb-Dependent Regulation of the Oocyte Epigenome and Its Impacts on Offspring
Patrick Western, Hudson Institute of Medical Research and Monash University, Clayton, Vic, Australia
11:20AM - 11:45AM | Germline Exposure to Sevoflurane Results in Dysregulation of Brain-Related Genes in Offspring
Vesna Jevtovic-Todorovic, University of Colorado School of Medicine, Aurora, CO, USA
11:45AM - 12:10PM | General Anesthetics Induce Epigenetic Alterations in Germ Cells that Result in Autism-like Behaviors
Hsiao-Lin V. Wang, Emory University, Atlanta, GA, USA
Mathia L Colwell, University of Minnesota, St. Paul, MN, USA
10:30 AM to 12:30 PM | Symposium 11: Developing Integrated Approaches to Testing and Assessment (IATA) Using an Adverse Outcome Pathway (AOP) Framework
Chairs: Anax Oliveria, Lhasa Limited, Leeds, United Kingdom, Bette Meek, University of Ottawa, Ottawa, ON, Canada
Location: Confederation III - Level 4
10:30AM - 10:50AM | Activation Levels of MIE Transcriptional Biomarkers Identify Liver Tumorigenic Dose Levels
J Chris Corton, U.S. EPA, Research Triangle Park, NC, USA
10:50AM - 11:10AM | Update on the Ongoing OECD Validation of the ToxTracker Assay for Genotoxic Mode of Action Assessment
Giel Hendriks, Toxys, Oegstgeest, Netherlands
11:10AM - 11:30AM | Developing Integrated Approaches to Testing and Assessment (IATA) Using an Adverse Outcome Pathway (AOP) Framework
Anthony Lynch, GlaxoSmithKline R&D, Genetic Toxicology & Photosafety, Stevenage, Hertfordshire, United Kingdom
11:30AM - 11:50AM | Integration of Data with Adverse Outcome Pathways (AOPs) to Support Genotoxicity Assessment
Steven Kane, Lhasa Limited, Leeds, United Kingdom
11:50AM - 12:10PM | Practical Application of AOPs in Regulatory Risk Assessments
Dr. Crina Heghes, Lhasa Limited, Leeds, United Kingdom
12:10PM - 12:30PM | Q&A Session
10:30 AM to 12:30 PM | Symposium 12: How Cells Tolerate and Replicate DNA Damage?
Chairs: Carlos FM Menck, University of São Paulo, São Paulo, Brazil, Vanesa Gottifredi, Fundación Instituto Leloir, Buenos Aires, Argentina
Location: Governor General I/II - Level 4
10:30AM - 11:00AM | Does the Error-Prone DNA Polymerase eta Replicate Pyrimidine Dimers Correctly?
Carlos FM Menck, Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP, Brazil
11:AM - 11:30AM | Revealing New Functions of the Translesion DNA Polymerase Zeta and the Consequences on Genome Stability
Patricia Kannouche, Goustave Roussy - CNRS, Villejuif, France
11:30AM - 12:00PM | Non-TLS (Translesion DNA Synthesis) Functions of TLS Polymerases
Vanesa Gottifredi, Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina
12:00PM - 12:15PM | The Essential Role of Oxidative Stress in Translesion Synthesis Deficient Human Patients Cells (XP-V)
Natália C Moreno, University of Sao Paulo (USP), Sao Paulo, SP, Brazil, National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA
Joonas Jamsen, NIEHS, RTP, USA
TUESDAY, AUGUST 30, 2022
10:30 AM to 12:30 PM | Symposium 13: De Novo Germline Mutations and Environmental Mutagenesis
Chairs: Kenichi Masumura, Division of Genetics and Mutagenesis, National Institute of Health Sciences, Kanagawa, Japan, Jonatan Axelsson, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden, Mathia
Colwell, University of Minnesota, Minneapolis, MN, USA
Location: Confederation I - Level 4
10:30AM - 11:00AM | Mutagenicity in Germ Cells and De Novo Mutations in the Offspring
Kenichi Masumura, National Institute of Health Sciences, Kanagawa, Japan
11:00AM - 11:30AM | Analysis of De Novo Germline Mutations in DNA Repair-Deficient Mice Lines
Mizuki Ohno, Kyushu University Fukuoka, Fukuoka Japan
11:30AM - 12:00PM | Duplex Sequencing for Mutations in Blood and Spermatozoa from Young Men – A Pilot Study
Jonatan Axelsson, Reproductive Medicine Centre, Skåne University Hospital, Malmö, Sweden. Lund University, Lund, Sweden. University of Ottawa, Ottawa, ON, Canada
12:00PM - 12:15PM | Harnessing Genomic Technologies for Assessing Germ Cell Mutagenicity in Humans and Laboratory Models
Francesco Marchetti, PhD, Health Canada, Ottawa, ON, Canada
10:30 AM to 12:30 PM | Symposium 14: Polynucleotide Signatures and Regulation of Genotoxin Stress Response
Chair: Robert Sobol, PhD, Point Clear Charities Professor, Department of Pharmacology Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA
New Investigator Co-Chairs: Ryan Barnes, PhD, University of Pittsburgh, Pittsburgh, PA, USA, Aishwarya Prakash, PhD, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA, Bret D. Freudenthal, PhD, University of Kansas, Kansas City, KS, USA
Location: Confederation II - Level 4
Joanna Loizou, PhD, Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria
Elise Fouquerel, PhD University of Pittsburgh, Pittsburgh, PA, USA
11:15AM - 11:45AM | RNA-mediated DNA Double Strand Break Repair
Youngkyu Jeon, Georgia Institute of Technology, GA, USA
Matthew J Meier, Health Canada, Ottawa, Ontario, Canada
12:00PM - 12:30PM | Poly-ADP-ribose in the Regulation of DNA Repair and the Cellular Response to Genotoxins
Robert Sobol, PhD, University of South Alabama, Mobile, AL, USA
10:30 AM to 12:30 PM | Symposium 15: New Approaches for Informing Population Variability in Chemical Risk Assessment
Chairs: Catherine Gibbons, US EPA, Washington, D.C., VA, USA, Michael Stewart, US EPA, Washington, D.C., VA, USA, Chelsea Weitekamp, US EPA, Washington, D.C., VA, USA
Location: Confederation III - Level 4
10:30AM - 11:00AM | New Approaches in Cancer Risk Assessment: Why study design matters
Mary Beth Terry, Columbia, New York, NY, USA
11:00AM - 11:30AM | Application of Bayesian and Probabilistic approaches for Cancer Dose-Response Assessment incorporating Model Uncertainty and Human Variability
Weihsueh A Chiu, Texas A&M University, College Station, TX, USA
11:30AM - 12:00PM | Approaches to Addressing Population Variability at CalEPA/OEHHA
Vincent James Cogliano, CalEPA Office of Environmental Health Hazard Assessment, Oakland, CA, USA
Danila Cuomo, Texas A&M University, College Station, TX, USA
John P Wise, Jr., University of Louisville, Louisville, KY, USA
10:30 AM to 12:20 PM | Symposium 16: From Genomes to Ecosystems: What Are the Ecological Consequences of Genotoxicity?
Chairs: Jason O'Brien, Environment and Climate Change Canada, Ottawa, ON, Canada, Gisela de Aragão Umbuzeiro, Universidade Estadual de Campinas, Campinas, Brazil, Awadhesh Jha, University of Plymouth, Plymouth, United Kingdom, Helina Gyasi, University of Ottawa, Ottawa, ON, Canada
Location: Governor General III - Level 4
10:30AM - 11:00AM | From Molecules to Ecosystems: An AOP-Based Perspective on the Current Status of the Field of Ecogenotoxicology
Jason M. O'Brien, Environment and Climate Change Canada, Ottawa, ON, Canada
11:00AM - 11:30AM | An Integrated Approach to Assess the Impact of Emerging Contaminants on Aquatic Organisms
Awadhesh N Jha, University of Plymouth, Plymouth, Devon, United Kingdom
11:30AM - 12:00PM | Ecogenotoxicological Effects Related to Coal Mining and Burning
Juliana da Silva, Universidade La Salle, Canoas, RS, Brazil
12:00PM - 12:15PM | Knowing the Resistance: 'Omics for Screening and Understanding the Impacts of Insecticide Resistance in Non-Target Species
Helen Poynton, University of Massachusetts, Boston, MA, USA
12:15PM - 12:30PM | Investigating the Mutagenicity of Polycyclic Aromatic Compounds from the Athabasca Oil Sands Region in River Otters and a Mammalian Cell Line
Helina Gyasi, University of Ottawa, Ottawa, ON, Canada
10:30 AM to 12:30 PM | Symposium 17: New Tools in Carcinogenicity Testing
Sponsored by: 
Chairs: Patricia Escobar, Merck & Co. Inc., West Point, NY, USA, Barbara Parsons, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA, Xilin "Shan" Li, National Center for Toxicological Research, Jefferson, AR, USA
Location: Governor General I/II - Level 4
10:30AM - 10:55AM | A Weight-of-Evidence Approach for Assessing Human Carcinogenic Risk of Small Molecule Pharmaceuticals that Reduces Reliance on Conventional Rodent Carcinogenicity Studies: An Overview of the ICH S1B(R1) Addendum
Patricia A. Escobar, Merck & Co. Inc., West Point, PA, USA
10:55AM - 11:20AM | Toxicogenomics in Carcinogenic Risk Assessment
Heidrun Ellinger-Zeigelbauer, Bayer AG, Wuppertal, NRW, Germany
11:20AM - 11:45AM | Duplex Sequencing for Quantitative Detection of Clonal Expansions for the in vivo Assessment of Nongenotoxic Carcinogens
Keith Tannis, Merck & Co, West Point, PA, USA
11:45AM - 12:10PM | Relationship Between Cancer Driver Mutational Based Biomarkers and Tissue-specific Tumor Susceptibility in Rodents
Kelly Harris, US Food & Drug Administration, National Center for Toxicological Research, Jefferson, AR, USA
Danielle LeBlanc, Environmental Health and Radiation Sciences Bureau, Health Canada, Ottawa, ON, Canada
3 PM to 5 PM | Symposium 18: Personalized Cancer Risk and Prevention: Models Integrating Genetics, Environmental Exposures, Infections, Diet, and Other Factors for Specific Cancers
Chairs: Rosalie Lijinsky, Silver Spring, MD, USA, Jonatan Axelsson, Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden, Clarissa Ribeiro Reily Rocha, Departamento de Microbiologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
Location: Confederation I - Level 4
Rosalie K Elespuru, US Food and Drug Administration, Silver Spring, MD, USA
3:30PM - 4:00PM | Colorectal Cancer Risk Factors and their Potential for Precision Prevention
Mingyang Song, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
4:00PM - 4:30PM | Risk Prediction of Gastric Cancer in Asian Populations: Its Potential Application to Personalized Prevention and Screening
Shoichiro Tsugane, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan
Idoia Meaza, University of Louisville, Louisville, KY, USA
Jun Xia, Creighton University, Omaha, NE, USA. Baylor College of Medicine, Houston, TX, USA
3 PM to 5 PM | Symposium 19: Novel Experimental Strategies for Investigating the Incidence and Mechanisms of Mutations
Chairs: Steve Rozen, Duke-NUS Centre for Computational Biology, Duke-NUS Medical School, Singapore, Singapore, Bevin Engelward Sc.D., Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
Location: Confederation II - Level 4
3:00PM - 3:10PM | Opening Statement
Bevin Engelward Sc.D., Department of Biological Engineering Massachusetts Institute of Technology, Cambridge, MA, USA, Steve Rozen, Duke-NUS Centre for Computational Biology, Duke-NUS Medical School, Singapore, Singapore
3:10PM - 3:32PM | Experimental Delineation of Mutational Signatures
Jiri Zavadil, International Agency for Research on Cancer, WHO, Lyon, Rhône-Alpes, France
3:32PM - 3:54PM | Using Normal Human Tissue-Derived Organoids to Identify Mutational Signatures of Environmental and Chemotherapeutic Agents
Jill E. Kucab, King’s College London, London, United Kingdom
3:54PM - 4:16PM | Opportunities and Challenges in Using Mutational Signature Analysis to Illuminate Cancer Biology and Epidemiology
Steven G Rozen, Duke-NUS Medical School, Singapore, Singapore
Joanna Loizou, Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria
4:38PM - 5:00PM | Application of Mutational Signatures of Carcinogens as Biomarkers of Cancer
Bogdan I. Fedeles, Massachusetts Institute of Technology, Cambridge, MA, USA
3 PM to 5 PM | Symposium 20: Risk Assessment of Low-Dose Rate Radiations, Lessons from the Fukushima Nuclear Accident
Chairs: Takayoshi Suzuki, National Institute of Health Sciences, Kawasaki, Japan, Yoshihisa Matsumoto, Tokyo Institute of Technology, Tokyo, Japan
Location: Confederation III - Level 4
3:00PM - 3:15PM | Fukushima Daiichi Nuclear Power Station Accident from the Aspect of Radiation Biology and Risk Communication
Yoshihisa Matsumoto, Tokyo Institute of Technology, Tokyo, Japan
3:15PM - 3:45PM | Long-term Strategies for Thyroid Health Monitoring After Nuclear Accidents: Recommendations from an Expert Group Convened by IARC
Kayo Togawa, International Agency for Research on Cancer, Lyon, France
3:45PM - 4:15PM | Evaluation of Biological and Health Effects in Response to Chronic Low Dose Radiation on Human Population: Current Scenario in High Background Radiation Areas of Kerala, India
Birajalaxmi Das, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India
4:15PM - 4:45PM | Experimental Studies on the Biological Effects of Chronic Low Dose-Rate Radiation Exposures in Mice
Ignacia lll B. Tanaka, Institute for Environmental Sciences, Rokkasho, Aomori, Japan
4:45PM - 5:00PM | Workshop Report: Fundamentals of Benchmark Dose Modeling and Application to Support Areas in the Radiation Field
Ngoc Q Vuong, Health Canada, Ottawa, ON, Canada
3 PM to 5 PM | Symposium 21: Role of RNA in DNA Repair
Chairs: Mats Ljungman, University of Michigan, Ann Arbor, MI, USA, Heather O'Hagan, University of Indiana, Bloomington, IN, USA
Location: Governor General I/II - Level 4
3:00PM - 3:15PM | Transcription for Genome Integrity
Mats Ljungman, University of Michigan, Ann Arbor, MI, USA
3:15PM - 3:45PM | Nucleotide Excision Repair Controls RNA Polymerase II levels
Manuel J. Muñoz, IFIBYNE, Buenos Aires, Argentina
3:45PM - 4:15PM | Molecular Mechanisms in Transcription-Coupled DNA Repair
Martijn S Luijsterburg, Leiden University Medical Center, Leiden, Netherlands
4:15PM - 4:45PM | DROSHA and DICER RNA Products Control PRC1-Dependent Transcriptional Repression at DNA Damage Sites
Sofia Francia, Istituto di Genetica Molecolare, Pavia, Italy
Peng Mao, University of New Mexico, Albuquerque, NM, USA
THURSDAY, SEPTEMBER 1, 2022
10:30 AM to 12:30 PM | Symposium 22: Dynamics of Mutation Acquisition in Somatic Cells: SNVs and SVs in the Brain, Blood and Beyond
Chairs: Thomas Wilson, University of Michigan, Ann Arbor, MI, USA, Thomas Glover, University of Michigan, Ann Arbor, MI, USA, Natalie Saini, Medical University of South Carolina, Charleston, SC, USA
Location: Confederation I - Level 4
10:30AM - 10:55AM | Interrogating the Architecture of Cancer Genomes
Peter Campbell, Wellcome Sanger Institute, Hinxton, Cambs, United Kingdom
10:55AM - 11:20AM | Single Cell Sequencing Reveals New Insights into Genomic Structural Variation
Jan O Korbel, European Molecular Biology Laboratory, Heidelberg, Germany. German Cancer Research Center, Heidelberg, Germany
11:20AM - 11:45AM | Recurrent Somatic Mutations in Human Neurons
Michael J. McConnell, Lieber Institute for Brain Development, Baltimore, MD, USA
11:45AM - 12:10PM | Implications of DNA Double-Strand Break Formation and Repair for Neural Progenitors and Mature Neurons
Bjoern Schwer, University of California, San Francisco, CA, USA
12:10PM - 12:2PM | Neurodegeneration-Associated TDP-43 Regulates Expression of Key DNA Mismatch Repair (MMR) Genes with Implications to Mutator Phenotype in Neurons
Vincent E Provasek, Texas A&M University, College Station, TX, USA. Houston Methodist Research Institute, Houston, TX, USA
10:30 AM to 12:30 PM | Symposium 23: Managing Genes in Space
Chairs: William Kaufmann, Past-President of EMGS, Durham, NC, USA, Tatiana Kozbenko, University of Ottawa, Ottawa, ON, Canada, Health Canada, Ottawa, ON, Canada
Location: Confederation II - Level 4
10:30AM - 11:00AM | New Insights into the Effects of Space Radiation on the Brain
Janet E. Baulch, University of California Irvine, Irvine, CA, USA
11:00AM - 11:15AM | Effects of Simulated Microgravity on Mammary Cells in 2 and 3 D Tissue Architecture
Janice M. Pluth, University of Nevada Las Vegas, Las Vegas, NV, USA
11:15AM - 11:45AM | Effects of Galactic Cosmic Rays and Other Environmental Factors in Space on the Cardiovascular System
Marjan Boerma, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Tatiana Kozbenko, Health Canada, Ottawa, ON, Canada. University of Ottawa, Ottawa, ON, Canada
12:00PM - 12:30PM | Individual Susceptible to Cancer from Space Radiation Exposure
Michael M. Weil, Colorado State University, Fort Collins, CO, USA
10:30 AM to 12:30 PM | Symposium 24: Using Quantitative Genetic Toxicology to Advance the Assessment of Genotoxic Impurities in Pharmaceuticals
Chairs: George Johnson, Swansea University, Swansea, United Kingdom, Andreas Zeller, Hoffman La Roche, Basel, Switzerland
Location: Confederation III - Level 4
10:30AM - 11:00AM | Quantitative Analysis of In Vivo Mutagenicity Dose Response Data for Risk Assessment and Regulatory Decision-making: A Case Study of Nitrosamines
George Johnson, Swansea University, Swansea, United Kingdom
11:00AM - 11:30AM | NDMA Induced Genotoxicity in the Low Dose Region in Muta™Mouse
Anthony M Lynch, GSK, Stevenage, Herts, United Kingdom
11:30AM - 12:00PM | Current Regulatory Risk Assessment Procedure and Regulatory Concerns with Using Quantitative Genetic Tox Data for Risk Assessment
Roland Froetschl, BfArM - Federal Institute for Drugs and Medical Devices, Bonn, Germany
Grace J Kocks, Lhasa Limited, Leeds, United Kingdom
10:30 AM to 12:30 PM | Symposium 25: R-loop Roadblocks to Transcription and Replication
Chairs: Philip Hanawalt, Department of Biology, Stanford University, Stanford, CA, USA, Andrés Aguilera, Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Seville, Spain, Yesenia Rodriguez, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
Location: Governor General I/II - Level 4
10:30AM - 11:00AM | Chromatin Modifications Upon Transcription-Dependent or Independent Replication Stress
Andrés Aguilera, Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC, Seville, Spain.
11:00AM - 11:30AM | Investigating the Mechanisms Behind R-Loop Induced Lethality Upon Replication-Transcription Conflicts
Houra Merrikh, Vanderbilt University, Nashville, TN, USA
11:30AM - 12:00PM | Toxic R-loops as a Cause and Consequence of Replication Stress
Philippe Pasero, Institut de Génétique Humaine, CNRS and Université de Montpellier, Montpellier, France
12:00PM - 12:15PM | The Multifaceted Roles of Base Excision Repair Enzymes in DNA Repair and R-loop Homeostasis
Yesenia Rodriguez, National Institute of Environmental Health Sciences, Durham, NC, USA
12:15PM -12:30PM | Perspectives on the Processing of R-loops by Nucleotide Excision Repair
Philip Hanawalt, Department of Biology, Stanford University, Stanford, CA, USA
(A short summary with references of recent research from Karlene Cimprich on Mechanisms for RNA-mediated Genome Instability)
1:30 PM to 3:30 PM | Symposium 26: Genome Editing: Intentional Mutagenesis of the Genome and Implications for Human Health
Chair: P.J. Brooks, NCATS, NIH, Bethesda, MD, USA
Location: Confederation I - Level 4
1:30PM - 2:00PM | Understanding Human Genetic Variation with Precision Genome Editing Tools
Alexis C Komor, University of California, San Diego, La Jolla, CA, USA
2:00PM - 2:30PM | Profiling Cell Type Specificity and Adverse Events of Genome Editing Nucleases in the Brain and Retina Using Single Cell Transcriptomics
Krishanu Saha, University of Wisconsin - Madison, Madison, WI, USA
Yusi Fu, Creighton University, Omaha, NE, USA
Takayoshi Suzuki, National Institute of Health Sciences, Kawasaki, Kanagawa, Japan
1:30 PM to 3:30 PM | Symposium 27: International Workshop on Genotoxicity Testing: Summary of Consensus Statements
Chairs: Hans-Joerg Martus, Novartis, Basel, Switzerland, David Kirkland, Kirkland Consulting, Tadcaster, United Kingdom, Andreas Zeller, Hoffmann La-Roche, Basel, Switzerland
Location: Confederation II - Level 4
1:30PM - 1:47PM | Transcriptomic Biomarkers
Roland Froetschl, Federal Institute for Drugs and Medical Devices, Bonn, Germany
1:47PM - 2:04PM | Predictivity of In Vitro Genotoxicity Testing, a Mathematical Modelling Approach
Mirjam Luijten, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
2:04PM - 2:21PM | Genotoxicity Dose-response Analysis for Potency Comparisons and Risk Assessment
Paul White, Health Canada, Ottawa, Canada
2:21PM - 2:38PM | In Vivo Strategies
Carol Beevers, Broughton-Group, Earby, Lancashire, United Kingdom
2:38PM - 2:55PM | Statistical Approaches and Data Interpretation
Stephen Dertinger, Litron Laboratories, Rochester, New York, USA
2:55PM - 3:12PM | Epigenotoxicity and Germ Cell Effects
Roger Godschalk, Maastricht University, Maastricht, Netherlands
3:12PM - 3:30PM | Gene Therapy
Silvana Libertini, Novartis Institutes for BioMedical Research, Basel, Switzerland
1:30 PM to 3:30 PM | Symposium 28: Carcinogens, Carcinogenesis and Cancer: Application of Artificial Intelligence and Machine Learning
Chairs: Luoping Zhang, School of Public Health, University of California, Berkeley, CA, USA, Maria Zhivagui, Department of Cellular and Molecular Medicine, University of California, San Diego, CA, USA
Location: Confederation III - Level 4
1:30PM - 2:00PM | How AI Can Beat Animal Testing at Finding Toxic Chemicals as Potential Carcinogens
Thomas Hartung, Johns Hopkins University, Baltimore, MD, USA
2:00PM - 2:15PM | Predicting the Binding of Small Molecules to Nuclear Receptors Using Machine Learning and Molecular Modeling Techniques
Azhagiya Singam Ettayapuram Ramaprasad, University of California - Berkeley, Berkeley, CA, USA
2:15PM - 2:30PM | Benchmarking Indel Detection Methods for Oncopanel Sequencing Data Through a PrecisionFDA Bioinformatics Challenge
Joshua Xu, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA
2:30PM - 3:00PM | COSMIC eSignatures: A collection of experimentally derived mutational signatures due to environmental agents
Maria Zhivagui, University of California San Diego, La Jolla, CA, USA
3:00PM - 3:30PM | A Multi-omic Approach and Bioinformatic Analysis of Exposures to Chemical Carcinogens
Luoping Zhang, University of California at Berkeley, Berkeley, CA, USA
1:30 PM to 3:30 PM | Symposium 29: Approaches for Studies of DNA Damage and Repair with Applications in Human Biomonitoring and Disease Risk Prediction
Chairs: Andrew Collins, University of Oslo, Oslo, Norway, Bevin Engelward, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA, Sabine Langie, Maastricht University, Maastricht, Netherlands
Location: Governor General III - Level 4
1:30 PM - 2:00PM | The Comet Assay; Past Success and Future Promise
Andrew Collins, University of Oslo, Oslo, Norway
2:00PM - 2:30PM | Measuring Nucleotide Excision Repair Capacity to Identify Disease Risk
Laura J Neidernhoffer, University of Minnesota Medical School, Minneapolis, MN, USA
Sabine Langie, Department of Pharmacology & Toxicology, School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, Netherlands
3:00PM - 3:15PM | Use of the CometChip for Public Health and Molecular Epidemiology
Bevin Engelward, Massachusetts Institute of Technology, Cambridge, MA, USA
Ann Karin Olsen, Norwegian Institute of Public Health, Division of Climate and Environmental Health, Oslo, Norway. Centre for Environmental Radioactivity (CERAD, Centre of Excellence of the Norwegian Research Council), Oslo, Norway
1:30 PM to 3:30 PM | Symposium 30: Mutagenic Hazards of PAHs and PAH Mixtures
Chairs: Yasunobu Aoki, National Institute for Environmental Studies, Tsukuba, Japan, Jennifer Keir, University of Ottawa, Ottawa, ON, Canada
Location: Governor General I/II - Level 4
1:30PM - 2:00PM | Genotoxic Effect of Polycyclic Aromatic Hydrocarbons Alone or in Mixture in Human Cells
Marc Audebert, INRAE, Toulouse, France
2:00PM - 2:30PM | Polycyclic Aromatic Compound Mixtures Research to Inform Component-based Risk Assessment
Cynthia Rider, NIEHS, Research Triangle Park, NC, USA
2:30PM - 3:00PM | In Vivo Mutagenesis of PAHs and Related Compounds Contained in Airborne Particles
Yasunobu Aoki, National Institute for Environmental Studies, Tsukuba, Japan
3:00PM - 3:15PM | Biomonitoring Studies of Exposure to Airport Emissions, Diesel Exhaust and Firefighting
Anne T Saber, National Research Centre for the Working Environment, Copenhagen, Denmark
3:15PM - 3:30PM | Firefighters’ Combustion-derived PAH Exposures and Investigating Exposure Reduction Methods
Jennifer Keir, University of Ottawa, Ottawa, ON, Canada