Poster No.

Session Title

Author's Name

Session No.

BLOCK 1 | 8:00-8:30AM CDT

Topic: Applied Genetic Toxicology

P1

CANCELLED POSTER: Classification of In Vitro Genotoxicants Requiring Metabolic Activation using a Multiplexed Assay (MultiFlowTM)

Robert Smith

2190

P2

A novel genome sequence-based mutagenicity assay using Salmonella typhimurium TA100 model improve mutagenicity and carcinogenicity evaluation of chemicals

Yuki Otsubo

2089

P3

Adopting Duplex Sequencing Technology for Genetic Toxicity Testing: A Proof-of-Concept Mutagenesis Experiment with N-Ethyl-N-Nitrosourea (ENU)-Exposed Rats

Stephanie L. Smith-Roe, PhD

2085

P4

Analysis Of The Cytotoxicity And Genotoxicity of Digested Titanium Dioxide Nanomaterials In Intestinal Cells

Henriqueta Louro

2094

P5

Concentration- and Time-Dependent Metabolic Activation and Genotoxicity of Benzo[a]pyrene in LMH 3D Spheroid

Tasnia Sharin

2153

P6

Detection of DNA damage in sea urchin coelomocytes with fast micromethod

Fengjia Liu

2104

P7

Determining Genotoxic Potential and Mode of Action in a Single Mammalian Cell Assay

Daniel J Roberts, MS

2140

P8

Dihydronicotinamide Riboside Promotes Cell-Specific Cytotoxicity by Tipping the Balance Between Oxidative Stress and Metabolic Regulation

Manoj Sonavane

2006

P9

Dihydroxyacetone Exposure Induces Metabolic Imbalance Induces Mitochondrial Dysfunction

Raj Mehta

2010

P10

Establishing A Hepatic Culture Model To Assess Altered Chemical Susceptibility Due To Pre-existing Liver Steatosis

Nyssa Tucker

2054

P11

Flow Cytometric Evaluation of Genotoxicity Pathways Induced by Non-Covalent DNA-Binders

Daniel J Roberts, MS

2178

P12

Genotoxicity Assessment Using In Vitro Micronucleus Assay and a High-Throughput Transcriptomic Biomarker, TGx-DDI

Hong Xie

2249

Poster No.

Session Title

Author's Name

Session No.

BLOCK 2 | 8:30-9:00AM CDT

Topic: Applied Genetic Toxicology

P13

HepaRG™CometChipÒ and HepaRG™ Micronucleus Assay as Non-Animal Alternatives to Follow Up Positive In Vitro Genotoxicity Findings: Case Study with Naphthalene

Leslie Recio, PhD, DABT

2192

P14

HESI Drug Case Study: An Integrated Approach to Pharmaceutical Safety Testing Using High-Throughput CometChip and TGx-DDI Analyses

Julie Kathleen Buick

2150

P15

In vitro mechanism of oxidative stress and DNA damage induction by insulin

Geema Kodandaraman

2229

P16

Particle size and solubility influence the uptake and genotoxicity of nickel compounds in bronchial epithelial BEAS-2B cells – toxic effect of nickel oxide nanoparticles halted by cytochalasin B

Kirsi Siivola

2138

P17

Potency of per- and polyfluoroalkyl substances (PFAS) in exposed human liver cell spheroids using high-throughput transcriptomics

Anthony John Reardon

2114

P18

Quantitative concentration-response analysis using the in vitro micronucleus test to inform genotoxicity evaluation for risk assessment of 292 chemicals

Byron Kuo

2143

P19

S-Allylcysteine Induces Cytotoxicity and Tumoral Growth Reduction in 3D-Multicellular Spheroids Derived from HepG2 cells

Tainá Keiller Leão

2176

P20

Transgenerational effect of N-nitrosodimethylamine in three generations of Drosophila melanogaster

Rubi Evangelista

2216

Topic: DNA Repair & Mutagenic Mechanisms

P21

Nucleotide Excision Repair Hotspots and Coldspots of UV Damage in Humans

Wentao Li

2020

P22

APE1 Cleavage of Abasic Ribonucleotides Embedded in DNA

Nicole Hoitsma

2165

P23

Autophagy Contributes To Xeroderma Pigmentosum Variant Cell Survival After UVA Light-Induced Oxidative Stress

Natália Cestari Moreno

2149

P24

Carbon Metabolism Impacts the Efficiency of Double-Strand Break Resection in Preparation for Homologous Recombination

Stephanie Lomonaco

2126

Poster No.

Session Title

Author's Name

Session No.

BLOCK 3 | 9:00-9:30AM CDT

Topic: DNA Repair & Mutagenic Mechanisms

P25

Characterizing Drosophila mutagen sensitive alleles through a collaborative Course-based Undergraduate Research Experience (CURE)

Elyse Bolterstein, PhD

2156

P26

CometChip Analysis of Human Primary Lymphocytes Enables Quantification of Inter-Individual Differences in the Kinetics of Oxidative Damage Repair

Simran Kaushal, MIT

2044

P27

CRISPR/Cas9 May Cause R-loops

Madeline Dzikowski

2148

P28

DNA Single-strand Break Repair and Signaling by APE1

Shan Yan, PhD

2011

P29

Droplet Digital PCR-Based Detection Of Mutant mRNAs Conferring Ciprofloxacin Resistance In P. aeruginosa

Libertad Garcia-Villada

2077

P30

Excision of Oxidatively Damaged Bases in G-quadruplexes by the DNA Glycosylases NEIL1 and mNeil3

Elizabeth Rose Lotsof

2023

P31

Faithful Ligation By DNA Ligase 1 And Its Role In Maintaining Genome Integrity

Mercedes E. Arana, Ph.D.

2155

P32

CANCELLED POSTER: Flap endonuclease 1 cleaves RNAs to resolve R-loops through DNA base excision repair

Yuan Liu, MD, PhD

2253

P33

CANCELLED POSTER: Genoprotective effects of Chaga mushroom (Inonotus obliquus) polysaccharides in UVB-exposed embryonic zebrafish (Danio rerio) through coordinated expression of DNA repair genes

Jehane Ibrahim, PhD

2194

P34

Genotoxicity of Omega-3 fatty acids from the Ames test viewpoint

Petr Grúz

2117

P35

Glycidamide-induced hypermutation in single stranded DNA

Kathleen Hudson

2098

P36

High Resolution in vivo Mapping of Yeast Mitotic DSB Resection Supports a Combined Endo- and Exonucleolytic Mechanism

Dominic Bazzano

2136

Poster No.

Session Title

Author's Name

Session No.

BLOCK 4 | 10:00-10:30AM CDT

Topic: DNA Repair & Mutagenic Mechanisms

P37

High-throughput Screening for Resistance to Colon Cancer-associated Carcinogen in Budding Yeast Identifies both DNA Repair and Ribosomal Protein Genes

Michael T. Fasullo, PhD

2064

P38

Impact Of G-quadruplexes On DNA Double-Strand Break Repair By End Joining

Shruthi Selvaraj

2154

P39

Insights from disease and tumor-related mutations in TFIIH and XPG

Susan Tsutakawa

2068

P40

Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs

Samantha L Sanford

2185

P41

Mechanistic Genotoxicity Assessment of Black Cohosh Extract in TK6 cells

Ji-Eun Seo

2091

P42

Metabolic Changes Caused by Endogenous Redox Stress Mirror Alterations Triggered by Exposure to Exogenous Oxidative Agents

Victoria Placentra

2101

P43

Novel roles for the Rad51 paralogs in DNA strand specific damage tolerance

Kara A. Bernstein, PhD

2090

P44

OXIDATIVE DAMAGE ATTENUATES NON-B DNA-INDUCED GENETIC INSTABILITY

Maha Zewail-Foote

2038

P45

Oxidative DNA Damage in Parkinson’s Disease-Associated Genes

Celeste Marin

2047

P46

Probing the Functional Impact of Cancer-Associated Variations within the Interdomain Connector of the Adenine Glycosylase MUTYH

Cindy Khuu

2022

P47

Regulation of budding yeast Hrq1 helicase during DNA crosslink repair

Thong Luong

2193

P48

CANCELLED POSTER: Single Molecule Visualization of Base Excision Repair Coordination

Max Fairlamb

2213

Poster No.

Session Title

Author's Name

Session No.

BLOCK 5 | 10:30-11:00 AM CDT

Topic: DNA Repair & Mutagenic Mechanisms

P49

Structural and Evolutionary Aspects of the Eukaryotic NER Pathway

Rayana dos Santos Feltrin

2202

P50

CANCELLED POSTER: UV-exposure and endogenous DNA damage cause genome changes in skin of healthy humans through synthesis across lesions and error prone double-strand break repair

Natalie Saini, Postdoc

2053

P51

Telomeric 8oxoG Damage Induces Cellular Senescence by Disrupting Telomere Replication

Ryan Barnes

2186

P52

CANCELLED POSTER: Temozolomide attenuates frataxin deficiency through contractions of GAA repeats via base excision repair

Yanhao Lai

2048

P53

The aging immune system drives senescence and dysfunction of peripheral tissues

Matt Yousefzadeh

2250

P54

The BRCA2-interacting protein, PDS5B, and SPIDR are novel Shu complex components

Sarah R. Hengel

2093

P55

The central DNA binding domain of XRCC1 stimulates the repair activity of the DNA glycosylase NTHL1

Robyn Maher

2036

P56

The effects of metabolic stress on Werner protein-deficient Drosophila

Elyse Bolterstein, PhD

2203

P57

The N-terminus of FBH1 is Critical for Anti-recombinase Activity in Human Cells

Alexandra Hawks

2021

P58

The NEIL1 DNA glycosylase interacts with mitochondrial transcription factor A in presence of DNA via its N-terminal domain

Nidhi Sharma

2080

P59

The Role of Error-Prone polymerases on Tumor Cell Resistance to Temozolomide

Marcela Teatin Latancia

2100

P60

The role of STEAP2 on aggressive prostate cancer traits and androgen responses

Leia Jones

2052

Poster No.

Session Title

Author's Name

Session No.

BLOCK 6 | 11:00-11:30AM CDT

Topic: DNA Repair & Mutagenic Mechanisms

P61

TIM-3 polymorphism regulates gene expression and is associated with the susceptibility and clinical prognosis of esophageal squamous cell carcinoma

Na Wang

2116

P62

*Topoisomerase 1 mutants and G-quadruplex-induced genomic instability. (Note: This poster will be presented during Block 9 | 2-2:30PM CDT)

Alexandra Berroyer*

2251

P63

Uncovering how RAD51C mutations contribute to cancer predisposition and sensitize to chemotherapeutics

Meghan Sullivan

2120

Topic: Epigenomics

P64

A strategy to identify compound-induced DNA methylation changes and potential association to genotoxicity

Rebekah Beck

2182

P65

Development and Validation of a Transcriptomic Biomarker of Chemical-Induced Histone Deacetylase Inhibition in TK6 Cells

Eunnara Cho

2170

P66

Differentially Expressed miRNAs and Functional Pathways Changes in Human Alveolar Epithelial Cells After 1 and 7 Days Exposure to MWCNT-7 or Asbestos

Célia Ventura

2163

P67

Epigenetic Effects of Early Life Aflatoxin Exposure in Rats

Alisa Dewald

2246

P68

miRNAs Associated With DNA Repair Are Upregulated By Environmental Toxicants

Pawlos Semere Tsegay

2049

P69

Neonatal Pb Exposure and DNA Methylation Profiles in Dried Bloodspots

Luke Benjamin Montrose

2248

P70

CANCELLED POSTER: rs2278176 Contributes to the favorable prognosis for metastatic colorectal cancer patients treated with FOLFOX

You Fu

2247

Topic: Gentoxicity Risk Assessment & Public Health

P71

A Simple Electrophoretic Assay for Quantification of Genomic DNA Damage

James Eduardo Lago Londero

2209

P72

Analytical pipeline for high-throughput gene expression profiling of per-and poly-fluoroalkyl substances (PFAS) in primary human liver cells spheroids to inform read-across

Andrea Rowan-Carroll

2103

Poster No.

Session Title

Author's Name

Session No.

BLOCK 7 | 1:00-1:30PM CDT

Topic: Gentoxicity Risk Assessment & Public Health

P73

Antigenotoxic Protective Effect Of Vitamin E And Of 𝞫-Carotene Evaluated By The Comet Assay And The Micronucleus Test In Female Recyclers Exposed To Contaminants Of The Cateura Landfill In Asunción Paraguay

Deidamia Mercedes Franco de Diana

2181

P74

Bisphenol S Induces Changes in C. elegans Maturation, Reproduction, and Genome

Noelle Jane Chung

2160

P75

Determining the association between genomic instability and prevalence of frailty syndrome in Portuguese older adults

Solange Costa

2164

P76

Genotoxicity of Microplastics: Local Aquatic Biomonitoring Suggests Burden of Environmental Plastic Pollution

Cassandra Haley

2188

P77

In Vivo Genotoxicity Assessment Of Multi-Wall Carbon Nanotubes Using Lung Micronucleus Assay

Katsuyoshi Horibata, PhD

2042

P78

Incidence of UVA and UVB Radiation And Its Genotoxic Potential During 2018 In Southern Brazil

Bruna Cogo Borin

2208

P79

Influence of Antioxidant Capacity on Micronucleus Induction by Cigarette Smoke in Various Mammalian Cell Lines

Tsuneo Hashizume

2013

P80

Mode-of-action Analysis of the Induction of Micronuclei by a Flavouring Compound in Vitro.

Satoru Munakata

2025

P81

Mycotoxins and Carcinogenesis: Disentangling Casual Links Through Epidemiological and Mechanistic Investigations

Liesel Claeys

2133

P82

Procarbazine-treated F344 rats have CD48-deficient bone marrow granulocytes with mutations in the Pig-a gene

Azra Dad

2180

P83

The Ames II assay as a component of the GeneTox21 high(er) throughput in vitro genetic toxicity assessment platform

Nikolai Chepelev, PhD

2142

P84

The use of the in vitro micronucleus assay on the genotoxicity assessment of cellulose nanofibrils in mammalian cell lines

Maria João Silva

2166

Poster No.

Session Title

Author's Name

Session No.

BLOCK 8 | 1:30-2:00PM CDT

Topic: Gentoxicity Risk Assessment & Public Health

P85

Validation of CACO-2/HT29-MTX Model to Assess the Potential Risk of Ingested Titanium Dioxide Nanoparticles

Dora Luísa Bispo Rolo

2084

Topic: Germ Cell and Heritable Effects

P86

Effect of repeated exposure to glyphosate on Drosophila melanogaster for fourteen generations

Hugo Rivas, Biologist

2207

P87

Exposure of Drosophila melanogaster females and males to Mitomycin (MMC) produces a different transgenerational effect

Estefania Arroyo Jilote, student

2211

P88

Scrutinizing Variants of Uncertain Significance in the PMS2 gene

Brandon D'Arcy

2115

P89

Smoking and Mutations in Sperm DNA

Jonatan Axelsson, MD, PhD

2008

Topic: In Vivo Mutagenesis

P90

Duplex Sequencing™ Demonstrates Dose-related Increases in Mutation Frequencies and C>A Transitions in the Bone Marrow of MutaMouse Males Exposed to Benzo(a)pyrene

Danielle LeBlanc

2122

P91

High Precision Risk Assessment System with Large-Scale Control Experiments in the Mouse

Yoichi Gondo

2132

P92

Temporal analysis of mutant frequencies in the bone marrow of MutaMouse males supports the 28+28 design as a single sampling time for in vivo mutagenesis

Gu Zhou

2102

P93

The in vivo Pig-a mutation assay is feasible in primary murine liver cells

Rebecca Lichtler

2205

P94

The rate and spectrum of EMS-induced mutations in the microcrustacean Daphnia: on the prospect of forward genetics

Marelize Snyman

2252

Topic: Other

P95

Characterization of Rat Testicular Organoids Exposed to Ionizing Radiation

Dayton Matthew Petibone

2137

P96

Dysregulation of NTHL1 and sensitivity to chemotherapeutic agents in human cells

Anirban Kar

2050

Poster No.

Session Title

Author's Name

Session No.

BLOCK 9 | 2:00-2:30PM CDT

Topic: Other

P97

Mechanisms of Activation and Detoxification of Aristolochic Acid and 3-Nitrobenzanthrone

Viktoriya Sidorenko, PhD

2152

P98

Novel LRRK2 transgenic mouse model to understand gene x environment interactions

Steven D Goodson

2082

P99

CANCELLED POSTER: Targeting spike glycoprotein of SARS-corona virus-2 with Chaga mushroom: An in silico study for developing a promising natural therapeutic.

Jehane Ibrahim, PhD

2197

Topic: The Genomics and Data Sciences

P100

A cross-platform and inter-laboratory evaluation of the TGx-DDI transcriptomic biomarker.

Andrew Williams

2141

P101

A robust analysis pipeline for lineage-based detection of mosaic copy number variants in single cells

Kai Wang

2161

P102

Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance

Nitika ., Graduate student

2157

P103

Investigating Genomic and Mutational Signatures of Organisms Living in Extreme Environments

Maximillian Soltysiak

2162

P104

Optimizing a bacterial laccase for effective oxidation of genotoxic emerging contaminants in wastewater: an in silico approach

Jia Hao Chen

2144

P105

TCDD-inducible poly-ADP-ribose polymerase regulates AHR biology and dioxin toxicity in rat

Alexandra S. Long, PhD

2206

P106

CANCELLED POSTER: Variation in mRNA Expression Patterns Explains Phenotypic Variation in Whole Animal Metabolism, Thermal Tolerance, and Cardiac Metabolic Rate of Fundulus Heteroclitus Populations Experiencing Variable Local Temperatures

Melissa Drown

2029

Late-Breaking Abstract

P107

Long-term Effects Of Wildfire Exposure During Early Childhood On The Methylome In Rhesus Macaques

Anthony P. Brown

2255