13th International Conference on Environmental Mutagens
Maintaining Genomic Health in a Changing World
53rd Annual Meeting of the EMGS
August 27 - September 1, 2022 - Ottawa Canada
About
ICEM 2022 Sponsors
Become a Sponsor
Diamond Level:
Morningside Foundation
NIEHS R13 Grant No. 5R13ES031435-03
TwinStrand Biosciences
Platinum Level:
Escher Fund for Autism
Health and Environmental Sciences Institute
Proctor & Gamble, Co.
US-FDA R13 Grant No. 5R13FD006702-04
University of Ottawa
MGI Americas Inc.
Carleton University
Gold Level:
Bristol Myers Squibb
Canadian Institutes for Health Research
Inotiv Inc.
Silver Level:
Burroughs Wellcome Fund
Elsevier
United Kingdom Environmental Mutagen Society
Gilead Sciences
National Cancer Institute (NCI)
Merck Research
Bronze Level:
Lhasa Limited
The Research Institute for Fragrance Materials
Moltox, Molecular Toxicology, Inc.
BASF Corp.
Toxys B.V.
Litron Laboratories
Instem
Kao Corporation
MultiCASE
Supporter
Mutagen-Brasil
Johnson & Johnson
University of Michigan
John J. Nicolette, MS, DABT
Contributors
European Environmental Mutagenesis and Genomics Society
Japanese Environmental Mutagen and Genome Society
Journal of Biochemistry
Illumina
Pfizer Inc.
Environmental and Molecular Mutagenesis Journal
Bill Kaufmann, PhD
Genetic Toxicology Association
Society of Toxicology
PLATFORMS
Ten thematic platform sections will take place during the five main days of the meeting providing an opportunity for 60 attendees to give a 15-min talk to present their work. The ten platform sessions are:
SUNDAY, AUGUST 28
Platform 1: In vitro Testing Strategies | 10:30AM to 12:30PM
Chair: Jeffrey Bemis, Litron Laboratories, Rochester, NY, United States, Co-Chair: Deborah Roubicek, CETESB - Sao Paulo State Environmental Agency, Sao Paulo, Brazil
NRF2 Modulates Ferroptosis in Temozolomide-Resistant Glioblastoma Cells | 10:30AM - 10:45AM
Clarissa Ribeiro Reily Rocha, UNIFESP, Sao Paulo, SP, Brazil
Empirical Testing of an Uncertainty Factor to Address Inter-Individual Variation in DNA Repair Genes in the Derivation of Genotoxicity Health Based Guidance Values | 10:45AM - 11:00AM
Lauren R Gallant PhD, University of Ottawa, Ottawa, ON, Canada
Establishment and Validation of the in Vitro Transgenic Rodent Assay Using Primary Hepatocytes From the MutaMouse | 11:00AM - 11:15AM
David Manuel Schuster, University Ottawa, Ottawa, ON, Canada; Health Canada, Ottawa, ON, Canada;
BASF SE, Ludwigshafen, Rheinland-Pfalz, Germany; SYNLAB, Leinfelden-Echterdingen, Baden-Württemberg, Germany
Fate of Micronuclei and Micronucleated Cells | 11:15AM - 11:30AM
Dr. Henning Hintzsche, University of Bonn, Bonn, Germany
In Vitro Genotoxicity Evaluation of PAHs in Mixtures Using Experimental Design | 11:30AM - 11:45AM
Rebecca Castel, IMBE, Marseille, France, LCE, Marseille, France
Investigation of Potential Respiratory Adverse Effects of Micro/nanofibrillated Cellulose and Cellulose Nanocrystals Using Human Lung Cell Line | 11:45AM - 12:00PM
Maria João Silva PhD, National Institute of Health Doutor Ricardo Jorge, Department of Human Genetics, Lisbon, Portugal; ToxOmics - Centre for Toxicogenomics and Human Health, NOVA Medical School, Universidade NOVA de Lisboa, Lisbon, Portugal
Development and Validation of Fourteen Human TK6-Derived Cell Lines That Individually Express a Human Cytochrome P450 for Genotoxicity Testing | 12:00PM - 12:15PM
Nan Mei PhD, National Center for Toxicological Research, Jefferson, AR, United States
A Multi-Biomarker Micronucleus Assay Using Imaging Flow Cytometry | 12:15PM -12:30PM
Danielle Harte, Swansea University Medical School, Swansea, United Kingdom; GSK R&D, Ware, United Kingdom
Platform 2: Emerging Public Health Issues | 3:00PM to 5:00PM
Chairs: Prof. Nina Holland, University of California - Berkeley, Berkeley, CA, USA, Jennifer Keir, University of Ottawa, Ottawa, ON, Canada
Exposure to Fipronil and Its Metabolites Disrupted Human Thyroid Cells | 3:00PM - 3:15PM
Zhiqiang Jiang, Fudan University, Shanghai, Shanghai, China
Reduction of Genomic Damage by Weight Loss | 3:15PM - 3:30PM
Dr. Helga Stopper, University of Wuerzburg, Wuerzburg, Bavaria, Germany
In Vitro Substantiation of the Harm Reduction Potential of Next Generation Nicotine Delivery Products Compared to Traditional Tobacco Products | 3:30PM - 3:45PM
Fiona Chapman, Imperial Brands, Bristol, United Kingdom
Arsenic Stressed Fibroblast-Derived Exosome Contains Molecular Cargo With Carcinogenic Potential | 3:45PM - 4:00PM
Vishnuvardhinidutt Kasi, Vellore Institute of Technology, Vellore, Tamil Nadu, India, University of Miyazaki, Miyazaki, Kyushu, Japan
How and How Much to Use Turmeric for the Reduction of Genotoxic Risk | 4:00PM - 4:15PM
Nagabhushan Moolky, Independent Consultant, Oak Brook, IL, USA
Traffic-related Air Pollution is Associated with Biomarkers of Oxidative Stress in Children | 4:15PM - 4:30PM
Nina Holland PhD, University of California, Berkeley, CA, USA
Pro-Inflammatory and Pro-Fibrogenic Effects of TiO2 and Ag-TiO2 Photocatalysts in the Murine Lung | 4:30PM - 4:45PM
Dr. Xiaoquan Huang, Southeast University, Nanjing, Jiangsu, China
Decreased Sperm Counts in Swedish Users of Oral Tobacco | 4:45PM - 5:00PM
Jonatan Axelsson M.D.,PhD, Reproductive Medicine Centre, Skåne University Hospital, Malmö, Sweden
Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden; Department of Translational Medicine, Lund University, Malmö, Sweden
MONDAY, AUGUST 29
Platform 3: Advances in DNA Repair I | 10:30AM to 12:30PMChair: Patricia Opresko, University of Pittsburgh, Pittsburgh, PA, USA, Co-Chair: Mariarosaria De Rosa, University of Pittsburgh, Pittsburgh, PA, USA, SNI Co-Chair: Nadja Cristhina de Souza Pinto, Universidade de São Paulo, Instituto de Química, São Paulo, Brazil
Examining the Role of LRRK2 in Genome Maintenance With Implications for Breast Cancer Disease Progression | 10:30AM - 10:45AM
Jennifer Liu B.S., Duke University, Durham, NC, USA
Tolerable Hypermutation Threshold Upon Acrolein and Chloroacetaldehyde Treatment Differently Influences the Fitness of Adaptive Response Defective E. Coli Strains | 10:45AM - 11:00AM
Izabela Dabrowska, Polish Academy of Science, Warsaw, Poland
Activation of Microglia and Impairment of Neurogenesis through DNA Repair Enzyme, MUTYH, in the Pathogenesis of Alzheimer’s Disease | 11:00AM - 11:15AM
Nona Abolhassani, Kyushu University, Fukuoka, Fukuoka, Japan
APE1 Promotes the DNA Damage Response in the Nucleoli | 11:15AM - 11:30AM
Shan Yan PhD, University of North Carolina at Charlotte, Charlotte, NC, USA
SWSAP1-SWS1 Stimulates D-Loop Formation on RPA-Coated SsDNA | 11:30AM - 11:45AM
Sarah R Hengel PhD, University of Pittsburgh, Pittsburgh, PA, USA
Replication Stress Induces Genomic Deletions with Microhomologous Junctions at Common Fragile Sites During M‑Phase | 11:45AM - 12:00PM
Thomas E. Wilson, University of Michigan, Ann Arbor, MI, USA
Alcohol Dehydrogenase-Mediated Activation of Glycidol Leads to the Generation of DNA-Crosslinking Metabolites | 12:00PM - 12:15PM
Yuya Fujita, Osaka Metropolitan University, Sakai, Osaka, Japan
Understanding Inter-Chromosomal Homologous Recombination to Repair Double-Strand Breaks in Stem and Progenitor Cells: The “Rainbow Mouse” Model | 12:15PM - 12:30PM
Kiran Lalwani, University of North Carolina Charlotte, Charlotte, NC, USA
TUESDAY, AUGUST 30
Platform 4: Environmental Mutagens I | 3:00PM to 5:00PMChair: P. David Josephy, University of Guelph, Guelph, ON, Canada, Co-Chair: Sabine Langie, Maastricht University, Maastricht, Netherlands, SNI Co-Chair: Anne-Marie Fortin, University of Ottawa, Ottawa, ON, Canada
A Look Beyond the Priority: A Comprehensive Investigation of the Toxicity of Retene | 3:00PM - 3:15PM
Francisco Carlos da Silva Junior, UFRN, Natal, RN, Brazil
In Vitro Transcriptomic Analyses Reveal Pathway Perturbations, Estrogenic Activities, and Potencies of Data-Poor BPA Alternative Chemicals | 3:15PM - 3:30PM
Geronimo Matteo MSc, University of Ottawa, Ottawa, ON, Canada
Environmental Health Science and Research Bureau, Ottawa, ON, Canada
Cytotoxic Metabolites of o-Toluidine and o-Anisidine Induce ALDH1A1 in Rat Bladder Epithelium | 3:30PM - 3:45PM
Takuma Kobayashi, Grad. Sch. Integr. Pharm. Nutr. Sci. Univ. Shizuoka, Shizuoka, Japan
Quantitative Genotoxicity Assessment of Mycotoxins Co-Occurring in Food and Feed | 3:45PM - 4:00PM
Julie Sanders, Scientific Direction of Chemical and Physical Health Risks, Sciensano, Brussels, Belgium;
Department of In-vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Brussels, Belgium
Toxicogenomic Effects of the Mycotoxins Deoxynivalenol and Patulin in Experimental Cell Models | 4:00PM - 4:15PM
Liesel Claeys M.S., International Agency for Reseach on Cancer (IARC), Lyon, France; Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium
Assessment of the Mutagenic Potential of a Protoporphyrinogen-Oxidase Inhibitor Herbicide | 4:15PM - 4:30PM
Dr. Naveed Honarvar, BASF SE, Ludwigshafen, Germany
Resistance of Mitochondrial DNA to Cadmium and Aflatoxin B1-Induced Germline Mutations Over 50 Generations of Exposure in C. Elegans | 4:30PM - 4:45PM
Tess Leuthner PhD, Duke University, Durham, NC, USA
Occupational Exposure to Inhalational Anesthetic in Veterinary Operating Rooms is Associated with Genetic Instability and Oxidative Stress | 4:45PM - 5:00PM
Mariana G Braz PhD, UNESP, Botucatu, SP, Brazil
WEDNESDAY, AUGUST 31
Platform 5: Environmental Mutagens II: 11:30AM to 12:30PMChairs: Awadhesh Jha University of Plymouth, Plymouth, United Kingdom, Alexandra Long, Health Canada, Ottawa, ON, Canada
Application of a New Approach Methodology (NAM)-based Strategy for Genotoxicity Assessment of Data-Poor Compounds | 11:30AM - 11:45AM
Anne-Marie Fortin, University of Ottawa, Ottawa, ON, Canada
Automated High Content Screening for Carcinogenicity Testing In Vitro | 11:45AM - 12:00PM
Linda Reilly, In Vitro Toxicology Group, Swansea University, Swansea, United Kingdom
Application of the ToxTracker Assay in the Consumer Goods Industry for Prioritization of Testing Strategies and Follow-Up Approaches | 12:00PM - 12:15PM
Ashley Allemang M.S., Procter & Gamble, Mason, OH, USA
In Vivo and in Vitro Evaluation of the Genotoxic Effects and Cellular Mechanisms of Fluoride | 12:15PM - 12:30PM
Ana Letícia Hilario Garcia PhD, Laboratory of Genetic Toxicology, Postgraduate program in Health and Human Development, La Salle University, Canoas, Rio Grande do Sul, Brazil;
Laboratory of Genetic Toxicology, Postgraduate program in Cellular and Molecular Biology Applied to Health, Lutheran University of Brazil, Canoas, Rio Grande do Sul, Brazil
Platform 6: Epigenomics and Heritable Effects: 11:30AM to 12:30PM
Chair: Barbara Hales, McGill University, Montreal, QC, Canada, Co-Chair: Patrick Allard, University of California, Los Angeles, CA, USA, SNI Co-Chair: Rachel Morgan, University of Michigan School of Public Health, Ann Arbor, MI, USA
DNA Methylation Programming and Environmental Influences During Rat Gametogenesis | 11:30AM - 11:45AM
Rhizlane El omri-Charai MSc, INRS- Armand Frappier Santé Biotechnologie, Laval, Quebec, Canada
A Gene Expression Biomarker Identifies Inhibitors of Two Classes of Epigenome Effectors in a Human Microarray Compendium | 11:45AM - 12:00PM
Jon Christopher Corton PhD, EPA, Durham, NC, USA
Exploring the Role of piRNA in Neural Differentiation and Its Susceptibility to Lead Exposure | 12:00PM - 12:15PM
Rachel Morgan MPH, University of Michigan Department of Environmental Health Sciences, Ann Arbor, MI, USA
Epigenomic And Transcriptomic Profiles In Inducible Models Of Mitochondrial DNA Copy Number Depletion And Heteroplasmic Burden | 12:15PM - 12:30PM
Amanda L. Morin HBSc, Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
Platform 7: Risk Assessment: 11:30AM to 12:30PM
Chair: Mirjam Luijten, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
Co-Chair: Gareth Jenkins, Swansea University, Swansea, United Kingdom
Cellular, Molecular and Genotoxic Effects of Digested Titanium Dioxide Nanomaterials | 11:30AM - 11:45AM
Henriqueta Louro, Department of Human Genetics, National Institute of Health Dr. Ricardo Jorge (INSA), Lisbon, Portugal, Centre for Toxicogenomics and Human Health (ToxOmics), NOVA Medical School, NOVA University, Lisbon, Portugal
Deriving an Optimal Transcriptomic Metric to Establish Protective and Relevant Transcriptomic Points of Departure for Risk Assessment Application | 11:45AM - 12:00PM
Anthony Reardon PhD, Existing Substances Risk Assessment Bureau, Healthy Environments & Consumer Safety Branch, Health Canada, Ottawa, ON, Canada
A Strategy for Developing a Framework of Genotoxicity Assays for Safety Assessment of Botanicals | 12:00PM - 12:15PM
Stefan Pfuhler PhD, Procter & Gamble, Mason, OH, USA
Thirdhand Smoke Exposure: Implications for inflammatory lung diseases | 12:15PM - 12:30PM
Altaf H Sarker, Lawrence Berkeley Lab, Berkeley, CA, USA
Platform 8: Advances in DNA Repair II: 11:30AM to 12:30PM
Chair: Bret D. Freudenthal, PhD, University of Kansas, Lawrence, KS, USA
Co-Chair: Dr. Tyler Weaver, University of Kansas, Lawrence, KS, USA
Unravelling The Multifunctionality of LigD in Bacterial DNA Repair | 11:30AM - 11:45AM
Dana J Sowa, McMaster University, Hamilton, ON, Canada
Understanding the Role of UV-DDB in the SMUG1-Mediated Repair of the Oxidative DNA Lesion, 5-Hydroxymethyl-2-Deoxyuridine | 11:45AM - 12:00PM
Sripriya J Raja, Graduate Program in Molecular Pharmacology, Pittsburgh, PA, USA;
Department of Pharmacology and Chemical Biology, Pittsburgh, PA, USA;
UPMC-Hillman Cancer Center, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Chronic Hyperglycemia Potentiates Oxidative and Neurotoxic Damage by Increasing Cell Death in Differentiated Neurons From SH-SY5Y Cells | 12:00PM - 12:15PM
Jéssica Ellen Barbosa de Freitas Lima, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Visualizing Base Excision Repair in Chromatin | 12:15PM - 12:30PM
Bret D Freudenthal PhD, University of Kansas Medical Center, Kansas City, KS, USA
Platform 9: In vivo Testing Strategies: 11:30AM to 12:30PM
Chair: Masami Yamada, National Defense Academy of Japan, Yokosuka, Japan, Co-Chair: Mizuki Ohno, Kyushu University, Fukuoka, Japan
Characterisation of Procarbazine-induced Mutation Spectrum in the Bone Marrow of MutaMouse Males using Duplex Sequencing | 11:30AM - 11:45AM
Annette E Dodge, University of Ottawa, Ottawa, ON, Canada; Health Canada, Ottawa, ON, Canada
Impact of Mgmt-Mediated DNA Repair on Mutation Susceptibility and Cancer in Mice | 11:45AM - 12:00PM
Lee J Pribyl PhD, Massachusetts Institute of Technology, Cambridge, MA, USA
Establishing Laboratory Proficiency in the OECD 488 Big Blue® Transgenic Rodent Somatic and Germ Cell Mutation Assay | 12:00PM 12:15PM
Matt Tate, Gentronix Ltd, Alderley Park, United Kingdom
Establishment of Cancer Cell Models Derived From Human iPS Cells Based on Mitochondrial Complex II Deficiency | 12:15PM - 12:30PM
Sugako Oka, Department of Medical Biophysics and Radiation Biology, Faculty of Medical Science, Kyushu University, Fukuoka, Fukuoka, Japan
THURSDAY, SEPTEMBER 1
Platform 10: Bioinformatics and Data Sciences: 10:30AM to 12:30PMChair: Kathleen Hill, Western University, London, Canada, Co-Chair: Christina Castellani, Western University, London, Canada, SNI Co-Chair: Amanda Morin, Western University, London, Canada
Sex-Specific DNA Methylation and Associations with in utero Tobacco Smoke Exposure at Nuclear-Encoded Mitochondrial Genes | 10:30AM - 10:45AM
Dillon E. King, Duke University, Durham, NC, USA
First Trimester Exposures to Per- and Polyfluoroalkyl Substances (PFAS) and Neonatal DNA Methylation | 10:45AM - 11:00AM
Rebekah L Petroff PhD, University of Michigan, Ann Arbor, MI, USA
Characteristics of de Novo Mutations (DNMs) in 13 Multi-Sibling Mexican-American Families | 11:00AM - 11:15AM
Habiballah Shojaeisaadi PhD, Health Canada, Ottawa, ON, Canada
Quantitative Analysis of GENOMARK Gene Expression Data to Compare Genotoxic Potencies | 11:15AM - 11:30AM
Anouck Thienpont MSc, Vrije Universiteit Brussel, Brussels, Belgium
Impact Of Wildfire Smoke on the Airway Epigenome | 11:30AM - 11:45AM
Hong Ji PhD, University of California, California National Primate Research Center, Davis, CA, USA
Mitochondrial DNA Copy Number and Heteroplasmy in Families with Monozygotic Twins Discordant for Schizophrenia | 11:45am - 12:00PM
Phyo Wei Win, Western University, London, ON, Canada
Artificial Intelligence (AI) Approaches as Alternatives to Animal Studies | 12:00PM - 12:15PM
Weida Tong PhD, FDA/NCTR, Jefferson, AR, USA