All times in Eastern Daylight Time.

WEDNESDAY, SEPTEMBER 22, 2021

Platform 01

12:15 PM -1:45 PM | Genetox in General  

12:15 PM to 12:30 PM | Estimation of Cutaneous Squamous Cell Carcinoma Incidence Attributable to Arsenic in U.S. Water Supplies 

Masaoki Kawasumi, MD, PhD, University of Washington, Seattle, WA (U.S.)

12:30 PM to 12:45 PM | Dead Cas9 Inhibits Uracil DNA Glycosylase Activity In Vitro

Jacob Antony, Washington State University, Pullman, WA (U.S.)

12:45 PM to 1:00 PM | Telomeric 8-Oxoguanine Drives Rapid Premature Senescence in the Absence of Telomere Shortening 

Ryan Barnes, University of Pittsburgh, Pittsburgh, PA (U.S.)

1:00 PM to 1:15 PM | Roles for BER Enzymes In Telomeric 8-Oxoguanine Processing And Telomere Maintenance

Mariarosaria De Rosa, University of Pittsburgh, Pittsburgh, PA (U.S.)

1:15 PM to 1:30 PM | Towards Omics Reporting Standards in Regulatory Toxicology: Introducing OECD Transcriptomics and Metabolomics Reporting Framework  

Carole Yauk, PhD, University of Ottawa, Ottawa, Ontario, (C.A.)

1:30 PM to 1:45 PM | Mechanistic Investigation of Black Cohosh Extract-Induced Genotoxicity in TK6 Cells 

Xiaoqing Guo, PhD, NCTR, US FDA, Jefferson, AR (U.S.)

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THURSDAY, SEPTEMBER 23, 2021

Platform 02

3:30 PM -5:00 PM | Mechanisms at Work 

3:30 PM to 3:45 PM | Mutagen-Driven Primary Cell Immortalization and Underlying Epigenomic and Transcriptomic Remodeling

Shefali Thakur, IARC,  Epigenomics and Mechanisms Branch, Lyons, France 

3:45 PM to 4:00 PM | Set2 Histone Methyltransferase Regulates Transcription Coupled Nucleotide Excision Repair in Yeast

Kathiresan Selvam, Washington State University, Pullman, Washington, (U.S.)

4:00 PM to 4:15 PM | Transcription Factors Bind to UV Lesions and Interfere with Damage Recognition by UV-DDB

Zachery Mielko, Duke University, Durham, NC, (U.S.)

4:15 PM to 4:30 PM | The Coordinated Handling of Damaged DNA by Base Excision Repair Proteins 

Max Fairlamb, University of Kansas Medical Center, Kansas City, KS, (U.S.)

4:30 PM to 4:45 PM | Titanium Dioxide Nanoparticles Molecular Effects: Internalization in the Human Intestinal Epithelium

Dora Luisa Bispo Rolo, PhD, National Institute of Health Dr. Richard Jorge, Lisbon, Portugal 

4:45 PM to 5:00 PM | Genotoxicity Assessment of Molnupiravir In Vitro and In Vivo

Patricia Escobar, PhD, Merck & Co, Inc, Kenilworth, NJ (U.S.)

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FRIDAY, SEPTEMBER 24, 2021

Platform 03

12:15 PM -1:45 PM | Genomic Instability and Motifs  

12:15 PM to 12:30 PM | Base Excision Repair of Oxidatively Damaged G-quadruplex DNA 

Amy Michelle Whitaker, PhD, University of Kansas Medical Center, Kansas City, KS (U.S.)

12:30 PM to 12:45 PM | Cruciform DNA Formed at Short Inverted Repeats: A Source of Genetic Instability In Vivo

Pooja Mandke, PhD University of Texas at Austin, Austin, TX, (U.S.)

12:45 PM to 1:00 PM | Chronic Hexavalent Chromium Exposure Causes Persistent Securin Disruption and Induces Chromosomes Instability

Jennifer Toyoda, University of Louisville, Louisville, KY, (U.S.)

1:00 PM to 1:15 PM | Germline Variant of NTHL1 Glycosylase Induces Defective DNA Repair, Replication Stress and Genomic Instability in Mouse Embryonic Fibroblasts Isolated From a Knock in Mice Model 

Lipsa Das, PhD University of Arizona, Tucson, AZ, (U.S.)

1:15 PM to 1:30 PM | Genetic Determinants of Disease Risk from Environmental DNA Damage 

Sarah Ruth Hengel, PhD, Department of Pharmacology and Chemical Biology, Pittsburgh, PA, (U.S.)

1:30 PM to 1:45 PM | DNA Hypermethylation Causes Genetic Instability by Altering DNA and Chromatin Structures 

Guliang Wang, University of Texas at Austin, Austin, TX, (U.S.)

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FRIDAY, SEPTEMBER 24, 2021

Platform 04

3:30 PM -5:00 PM | Tools and New Technology

3:30 PM to 3:45 PM | Adopting Duplex Sequencing Technology for Genetic Toxicity Testing: A Proof-of-Concept Mutagenesis Experiment with N-Ethyl-N-Nitrosourea (ENU)-Exposed Rats

Stephanie Smith-Roe, PhD, Division of the National Toxicology Program/NIEHS, Research Triangle Park, NC, (U.S.)

3:45 PM to 4:00 PM | CarcSeq Quantification of Lung Cancer Driver Mutations Forecasts Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia  

Kelly Harris, PhD, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, (U.S.)

4:00 PM to 4:15 PM | In Vitro Micronucleus Assay Benefits from a Panel of DNA Damage Response Biomarkers  

Stephen Dertinger, PhD, Litron Laboratories, Rochester, NY, (U.S.)

4:15 PM to 4:30 PM | Deploying Artificial Intelligence and Systematic Review Tools in Adverse Outcome Pathway Development: A Space Travel Case Study

Tatiana Kozbenko, MSc, Health Canada & University of Ottawa, Ottawa, ON, (U.S.)

4:30 PM to 4:45 PM | The Use of ROS Scavengers and the ToxTracker® Assay For Mode of Action Information as a Follow-up For Positive Findings in the TK6 Micronucleus Assay

Ashley Allemang, MS, Proctor & Gamble, Cincinnati, OH, (U.S.)

4:45 PM to 5:00 PM | Towards a Better Prediction of Xenobiotic Genotoxicity: Cometchip Technology Coupled With A 3D Model of HepaRG Human Liver Cells 

Audrey Barranger, ANSES, Fougères, France

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SATURDAY, SEPTEMBER 25, 2021

Platform 05

12:15 PM -12:45 PM | Smoke, Tobacco and Nicotine

12:15 PM to 12:35 PM | Exposure to Polycyclic Aromatic Hydrocarbons and Nicotine, and Sperm DNA Fragmentation

Jonatan Axelsson, MD, PhD, Lund University and Skane University Hospital, Malmö, Sweden

12:35 PM to 12:50 PM | Integrative Toxicogenomic Analysis of Cell Exposure to Arsenic and Smokeless Tobacco

Samrat Das, PhD, International Agency for Research on Cancer, Lyon, France

12:50 PM to 1:10 PM | Tobacco Smoke Exposure Alters CD8 T Cell Composition Towards Immune Dysfunction And Aging

Michelle Renee Campbell, MB, NIEHS/NIHS, Durham, NC, United States 

1:10 PM to 1:25 PM | The Pyridyloxobutyl DNA Adducts Formed From Tobacco Specific Nitrosamines Yield a Unique Mutational Signature in Both Cell and Animal Models 

Lisa Peterson, PhD University of Minnesota, Saint Paul, MN, (U.S.)

1:25 PM to 1:45 PM | Early-Life Wildfire Smoke Exposure Leads To Long-Term Changes To The Methylome In Rhesus Macaques 

Anthony Brown, PhD, University of California, Davis, CA, (U.S.)

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SATURDAY, SEPTEMBER 25, 2021

Platform 06

3:30 PM -5:00 PM | In Utero and Developmental Effects of Chemicals

3:30 PM to 3:45 PM | The Mutational Landscape of Human Somatic and Germline Cells 

Raheleh Rahbari, Sanger Institute, Hinxton, Cambridgeshire (U.K.)

3:45 PM to 4:00 PM | Advanced Age Increases Frequencies of De Novo Mitochondrial Mutations in Macaque Oocytes and Somatic Tissues 

Barbara Arbeithuber, Johannes Kepler University, Linz, Austria

4:00 PM to 4:15 PM | The Association Between Serum Oestradiol Levels and Sperm DNA Integrity

Viktor Lu, Lund University, Lund, Scania, Sweden

4:15 PM to 4:30 PM | Early Gestational Bisphenol Exposure and DNA Methylation in Placenta, Cord Tissue, and Infant Cord Blood

Carolyn McCabe, PhD, University of Michigan, Ann Arbor, MI, (U.S.)

4:30 PM to 4:45 PM | Intergenerational Effects of In Utero Arsenic Exposure on Mouse Physiology and Epigenome

Mathia Colwell, PhD, University of Minnesota, Saint Paul, MN, (U.S.)

4:45 PM to 5:00 PM | Sex-Specific Programming of Cardiac DNA Methylation in Weanling Mice by Developmental Lead Exposure 

Laurie Svoboda, PhD, University of Michigan, Ann Arbor, MI, (U.S.)

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