Environmental Mutagenesis & Genomics Society
Virtual Annual Meeting
September 22-25, 2021

EMGS 2021:
Virtual Meeting, Real Science

Block 1: Poster Session Q&A

Monday, September 20, 2021 from 11:00 AM to 1:00 PM

Guests are encouraged to watch the prerecorded Poster Sessions before Monday, September 20th to attend the live Q&A. Guests can enter questions they have for the author in the right-hand column on the individual Poster session on the 2021 EMGS Virtual Event Site. During the Q&A Session on Monday, September 20 from 11:00 AM to 12:25 AM  each poster author has 5 minutes to answer questions. The following times are tentative. If a speaker does not use the full 5 minutes, the moderators will move on to the next poster author.  

 For the guidelines and instructions on how to make your poster video, click here.

DNA Repair Mutagenic Mechanisms

11:00 AM to 11:05 AM (EDT) | PS1- Sequence and Structural Analysis of Zinc Finger GRF Motifs in Genome Integrity

Joshua Matos, University of North Carolina at Charlotte, Charlotte, NC, (U.S.)

11:05 AM to 11:10 AM (EDT) | PS6- Contractions of trinucleotide repeats through base excision repair attenuates frataxin deficiency in Friedreich’s ataxia

Yuan LiuMD, PhD, Florida International University, Miami, FL, (U.S.)

11:10 AM to 11:15 AM (EDT) | PS3- Mechanistic Insight into Cleavage of an Abasic Site in Single Stranded DNA by AP-Endonuclease 1 (APE1)

Nicole Hoitsma, University of Kansas Medical Center, Kansas City, KS, (U.S.)

11:15 AM to 11:20 AM (EDT) | PS4- Damaged DNA Containing Cyclobutane Pyrimidine Dimers is associated with Small Extracellular Vesicles

M. Alexandra Carpenter, Wright State University, Dayton, OH, (U.S.)

11:20 AM to 11:25 AM (EDT) | PS5- Particulate Hexavalent Chromium Induces Loss of RAD51 Leading to Increased Genomic Instability, A Driver of Carcinogenesis

Idoia Meaza, University of Louisville, Louisville, KY, (U.S.)

11:25 AM to 11:30 AM (EDT) | PS2- DNA Base Excision Repair Capacity in Tissues of Friedreich’s Ataxia Transgenic Mice

Alycia Shariff, Florida International University, Miami, FL, (U.S.)

11:30 AM to 11:35 AM (EDT) | PS7- Determining How Ribonucleotides Impact Telomere Integrity

Griffin Welfer, University of Kansas Medical Center, Kansas City, KS, (U.S.)

11:35 AM to 11:40 AM (EDT) | PS8- PARP1 and PARP2 Cooperation in the Prevention of Oxidative Stress-Mediated Telomere Crisis

Daniela Muoio, Thomas Jefferson University, Philadelphia, PA, (U.S.)

11:40 AM to 11:45 AM (EDT) | PS9- Understanding the Cell Type Specificity on Potential for Inter- Chromosomal Homologous Recombination to Repair Chromosomal Double-breaks Using a Unique “Rainbow Mouse” Model

Kiran Lalwani, University of North Carolina at Charlotte, Charlotte, NC (U.S.)

11:45 AM to 11:50 AM (EDT) | PS10- Application of Modifying Agents to a Multiplexed DNA Damage Response Assay Yields Deeper Insights to Clastogenic Mechanisms

Steven Bryce, Litron Laboratories, Rochester, NY, (U.S.)

11:50 AM to 11:55 AM (EDT) | PS11- A Budding Yeast System for Measuring CYP1B1-activation of Genotoxins

Michael Fasullo, SUNY Polytechnic Institute, Marcy, NY, (U.S.)

11:55 AM to 12:00 PM (EDT) | PS12- 3D Skin Comet Assay Using Phenion® Full-Thickness Skin Models: A Good Follow-up Tool to De-risk Genotoxicity of in vitro Positives

Annie Hamel, Charles River Laboratories, Senneville, Quebec, Canada

12:00 PM to 12:05 PM (EDT) | PS14- Biological Impact of Low Dose Radiation on Mitochondrial Defective Lymphoblastoid Cells

Janice Pluth, University of Nevada, Las Vegas, Las Vegas, NV, (U.S.)

12:05 PM to 12:10 PM (EDT) | PS15- Interaction Between Methionine Restriction and Cisplatin on DNA Damage and Apoptosis

Tripti Shukla, University of Arkansas for Medical Services, University of Arkansas at Little Rock, Little Rock, AR, (U.S.)

12:10 PM to 12:15 PM (EDT) | PS16- Investigating the Effects of Clustered DNA Damage on Increased Transcriptional Mutagenesis and Related Toxicity of Mutant Alpha-Synuclein

Morni Modi, Department of Molecular and Cellular Physiology, LSU, Shreveport, LA, (U.S.)

12:15 PM to 12:20 PM (EDT) | PS17- Strong Mutagenicity of 3-azido-1,2-propanediol in Human Cells.

Petr Gruz, National Institute of Health Sciences, Kawasaki, (Japan)

12:20 PM to 12:25 PM (EDT) | PS18- RNA-guided DNA Synthesis by DNA Repair Polymerases Mediates DNA Strand Break Repair

Pawlos Semere Tsegay,  Biochemistry Ph.D. Program, Florida International University, Miami, FL, (U.S.)

12:25 PM to 12:30 PM (EDT) | PS19- Oxidative RNA Damage Disrupts N6-methyladenosine (m6A) Profile Leading to Deregulation of the DNA Repair Gene

Fe Qu, Biochemistry Ph.D. Program, Florida International University, Miami, FL, (U.S.)

12:30 PM to 12:35 PM (EDT) | PS20- A Whale of a Tale: Whale Lung Cells Resist Particulate Cr(VI)-Induced Chromosome Instability

John Pierce Wise, Sr, Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, (U.S.)

12:35 PM to 12:40 PM (EDT) | PS21- Particulate Hexavalent Chromium Targets RAD51 Paralogs Leading to Loss of Homologous Recombination Repair in Metal Carcinogenesis

Aggie Rena Williams, Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, (U.S.)

12:40 PM to 12:45 PM (EDT) | PS22- Identification of Human Mitochondrial Transcription Factor A as an Interaction Partner of the NEIL1 DNA Glycosylase

Nidhi Sharma, University of South Alabama, Department of Biochemistry and Molecular Biology, Mitchell Cancer Institute, Mobile, AL, (U.S.)

12:45 PM to 12:50 PM (EDT) | PS23- Impact of G-quadruplexes on DNA Double-Strand Break Repair by End-Joining

Shruthi Selvaraj, Department of Biomedical Sciences, University of Illinois at Chicago, College of Medicine, Rockford, IL, (U.S.)

12:50 PM to 12:55 PM (EDT) | PS24- Characterization of Novel Single-Domain Nanobodies Against NEIL1

Marlo K. Thompson, Mitchell Cancer Institute, University of South Alabama Health, Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL, (U.S.)

12:55 PM to 1:00 PM (EDT) | PS25- Cancer-Associated Topoisomerase 1 Mutants and G-Quadruplex-Induced Genomic Instability

Alexandra Berroyer, University of Texas Health Science Center, Houston, TX, (U.S.)


Block 2: Poster Session Q&A

Tuesday, September 21, 2021 from 11:00 AM to 1:05PM

11:00 PM to 11:05 PM (EDT) | PS26- Analysis of UVA Radiation Induced Mutagenesis in Translesion Synthesis-deficient Human Cells

Camila Corradi, DNA Repair Laboratory, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, (Brazil)

11:05 PM to 11:10 PM (EDT) | PS27- Bioflavonoids and Environmental Compounds Generate DNA Damage through Topoisomerase II Inhibition and Oxidative Stress

Destiny McKleny, University of North Carolina at Charlotte, Charlotte, NC, (U.S.)

11:10 PM to 11:15 PM (EDT) | PS28- Revealing the Molecular Mechanisms of Maintaining ssDNA Stability

Shan Yan, University of North Carolina at Charlotte, Charlotte, NC, (U.S.)

11:15 PM to 11:20 PM (EDT) | PS29- Single-molecule Tools to Directly Visualize DNA-binding Proteins

Jason Lin, LUMICKSWaltham, MA, (U.S.)

Epigenomics

11:20 PM to 11:25 PM (EDT) | PS30- Differential Expression of Murine piRNAs in Adult Tissues Following Perinatal Lead Exposure

Bambarendage Pinithi Upekka Perera, University of Michigan, Ann Arbor, MI, (U.S.)

11:25 AM to 11:30 AM (EDT) | PS31- Prenatal Exposures to Common Phthalates and Prevalent Phthalate Alternatives are Associated with Infant DNA Methylation at Birth

Rebekah Petroff, University of Michigan, Ann Arbor, MI, (U.S.)

11:30 AM to 11:35 AM (EDT) | PS32- Triclosan Down-regulates Fatty Acid Synthase Through MicroRNAs in Human Hepatocytes

Zunzhen Zhang, Department of Environmental and Occupational Health, Sichuan University West China School of Public Health and West China Fourth Hospital, Chengdu, Sichuan, (China)

Applied Genetic Toxicology

11:35 AM to 11:40 AM (EDT) | PS33- Soap And Water Is the Most Effective Skin PAH Decontamination Method For Firefighters, But It Doesn't Reduce The Internal Dose

Jennifer L. Keir, Department of Biology, University of Ottawa, Ottawa, ON, (Canada)

11:40 AM to 11:45 AM (EDT) | PS34- Optimal Design of In Vivo Studies Employed for Quantitative Assessment of Genotoxicity

Alexandra Long, PhD, University of Toronto, Ottawa, ON, (Canada)

11:45 AM to 11:50 AM (EDT) | PS35- What Different Mutagens Do Salmonella TA98 and TA100 Detect?

Kevin Cross, PhD, Instem, Stone, (U.K.)

11:50 AM to 11:55 AM (EDT) | PS36- Micro(nano)-plastics induction of inflammation and DNA damage: Does it have implications for cancer development?

Chibuisi Gideon Alimba, University of Ibadan, Ibadan, (Nigeria)

11:55 AM to 12:00 PM (EDT) | PS37- Dihydroxyacetone Exposure Induces Metabolic and Mitochondrial Stress In HepG3 Cells

Arlet Hernandez, Department of Physiology and Cell Biology, University of South Alabama, College of Medicine, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, (U.S.)

12:00 PM to 12:05 PM (EDT) | PS38- Temporal and Concentration Concordant Evidence Supporting That Increases in Reactive Oxygen Species Lead to Chromosomal Aberrations in an Adverse Outcome Pathway

Elizabeth Huliganga, University of Ottawa, ON, Canada 

12:05 PM to 12:10 PM (EDT) | PS39- Quantitative Dose Response Modelling of Historical ToxTracker Data to Evaluate in Vitro Genotoxicity and Mode of Action

Inger Brandma, Toxys, Leiden, (Netherlands)

12:10 PM to 12:15 PM (EDT) | PS40- NRF2 Modulates Ferroptosis in Temozolomide-Resistant Glioblastoma Cells

Izadora de Souza, Department of Clinical and Experimental Oncology, Federal University of São Paulo (UNIFESP), SP, (Brazil)

12:15 PM to 12:20 PM (EDT) | PS41- Mutagenic and Antimutagenic Assessment of Ellagitannin Eugeniflorin D2 in Bacteria and Mice

Bruno Franco Fernandes Barbosa, Federal University of Goiás, Goiânia, GO, (Brazil)

12:20 PM to 12:25 PM (EDT) | PS42- The Establishment of Whole-genome Sequencing-based Mutation Analyses Method Using Human Cells

Takako Hirose, R&D, Safety Science Research, Kao Corporation, (Japan)

12:25 PM to 12:30 PM (EDT) | PS43- 3Rs-Aligned Strategy for Demonstrating Proficiency of the Rodent Micronucleus Assay in Peripheral Blood with Organ Specific Assessment of DNA Damage using the Alkaline Comet Assay

Daniel Roberts, Charles River, Skokie, IL, (U.S,)

12:30 PM to 12:35 PM (EDT) | PS44- Deuteration Increases the Sensitivity of Escherichia Coli To UVC DNA Damaging Effect

SV Smirnova, Vavilov Institute of General Genetics Russian, Academy of Sciences, Gubkina str. 3, Moscow, (Russia)

12:35 PM to 12:40 PM (EDT) | PS45- Use of the TGx-DDI Transcriptomic Biomarker for Genotoxicity Assessment of Data-poor Chemicals

Anne-Marie Fortin, Department of Biology, University of Ottawa, Ottawa, ON, (Canada)

12:40 PM to 12:45 PM (EDT) | PS46- Evaluation of Pyrrolizidine Alkaloid-induced Genotoxicity Using Metabolically Competent TK6 Cell Lines.

Xilin Li, Division of Genetic and Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, (U.S.)
Genotoxicity Risk Assessment and Public Health

12:45 PM to 12:50 PM (EDT) | PS47- Biological Monitoring of Residents Exposed to Environmental Occupation Using the Buccal Micronucleus Approach

Olga Tselousova, Bashkir State Medical University of the Ministry of Health, (Russia)

12:50 PM to 12:55 PM (EDT) | PS48- Cancer Risk Assessment for Medical Devices: Shifting Paradigms by Integrating Diverse Datasets

Catherine Fischer, US FDA/CDRH, Silver Spring, MD, United States

12:55 PM to 1:00 PM (EDT) | PS49- The Effect of DNA Repair Knock-out on Sensitivity to Environmental Mutagens: Comparative Analyses of In Vitro Concentration-Response Data

Lauren Gallant, Department of Biology, University of Ottawa, Ottawa, ON, (Canada)

1:00 PM to 1:05 PM (EDT) | PS50- NanoAmes™: An Ultra-miniaturized Format of Ames Test

Dimitrios Spiliotopoulos, Xenometrix AG, Allschwil, (Switzerland)


Block 3: Poster Session Q&A

Wednesday, September 22, 2021 from 10:00 AM to 12:00 PM

10:00 AM to 10:05 AM (EDT) | PS51- Comparing Potencies of BPA Alternatives Using a Novel Global Transcriptomic Sequencing Analysis

Geronimo Parodi-Matteo, University of Ottawa, Ottawa, ON, (Canada)

10:05 AM to 10:10 AM (EDT) | PS52- Usefulness of historic Ames test data – Sensitivity of the Ames test at 10% the maximum OECD TG471 guideline dose and of the two-strain Ames, in the context of a 2-test battery

Stefan Pfuhler, PhD, Global Product Stewardship, Procter & Gamble, Cincinnati, OH, (U.S.)

10:10 AM to 10:15 AM (EDT) | PS53- Molecular and High-Content Analysis Suggests Parthanatos Cell Death as Mechanism for the Antitumoral Effects Exerted by Brachydin A Flavonoid in 3D Prostate (DU145) Tumor Spheroids

Diego Luis Ribeiro, Ribeirão Preto Medical School - University of São Paulo, Ribeirão Preto, SP, (Brazil)

10:15 AM to 10:20 AM (EDT) | PS54- In Vivo Genotoxicity Assessment of Multi-Walled Carbon Nanotubes Using the Optimized Lung Micronucleus Assay

Katsuyoshi Horibata, Division of Genetics and Mutagenesis, National Institute of Health Sciences, Kanagawa, (Japan)

10:20 AM to 10:25 AM (EDT) | PS55- Quantitative Assessment of DNA Damage Dose-responses Between 2D and 3D HepaRG Models Using the High-throughput CometChip Assay

Ji-Eun Seo, Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR, (U.S.)

10:20 AM to 10:25 AM (EDT) | PS56- Polycyclic Aromatic Hydrocarbon Potency Equivalence Factors Determined Using In Vivo Mutagenicity Dose-response Data

Hannah Battaion, Environmental Health Science & Research Bureau, Health Canada, Ottawa, ON, (Canada)

10:25 AM to 10:30 AM (EDT) | PS57- Identification of a Novel Mode of Action to Induce Micronuclei by 1-(4-methoxyphenyl)pent-1-en-3-one

Satoru Munakata, Japan Tobacco Inc., Tokyo, (Japan)

10:30 AM to 10:35 AM (EDT) | PS58- Repeated Exposure to Eucalyptus Smoke Alters Pulmonary Gene Expression in Male Long-Evans Rats

Helen Nguyen, Oak Ridge Institute for Science and Education, U.S. Environmental Protection Agency, RTP, NC, (U.S.)

10:35 AM to 10:40 AM (EDT) | PS59- The Botanical Safety Consortium’s Strategy for Developing a Toolkit of Assays for Robust Genotoxicity Assessments of Botanicals 

Kristine Witt, NIEHS/Division of the National Toxicology Program, Research Triangle Park, NC, (U.S.)

10:40 AM to 10:45 AM (EDT) | PS60- Exploring Potential Genotoxic Effects of Nanocelluloses Versus Multi-walled Carbon Nanotubes in Co-cultures of Human Lung Epithelial Cells and Monocyte-derived Macrophages 

Fatima Pinto, Instituto Nacional de Saúde Doutor Ricardo Jorge, Department of Human Genetics, Lisbon, (Portugal)

10:45 AM to 10:50 AM (EDT) | PS61- Study of Genotoxicity of Nanomaterials Using 2D and 3D HepaRG Liver Cell Models

Julia Varet, The French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Fougères, (France)

10:50 AM to 10:55 AM (EDT) | PS62- Unclassified Chromosomal Abnormalities as an Indicator of Genomic Damage and Instability in Survivors of Hodgkin's Lymphoma

Sandra Ramos, Laboratorio de Citogenética del Instituto Nacional de Pediatría, UNAM, (Mexico)

Genomics and Data Sciences

10:55 AM to 11:00 AM (EDT) | PS63- Intrinsic base substitution patterns in diverse species reveal links to cancer and metabolism

Kin Chan, University of OttawaOttawa, ON, (Canada)

11:00 AM to 11:05 AM (EDT) | PS64- High-throughput Assessment of Increased Chemical Toxicity Due to Hepatic Steatosis

Nyssa Tucker, ORISE, US EPAOak Ridge, TN, (U.S.)

11:05 AM to 11:10 AM (EDT) | PS65- Whole-genome Duplex Sequencing reveals landscape of antibiotic-induced mutations in Escherichia coli

Devon Fitzgerald, Baylor College of Medicine,  Houston, TX, (U.S.)

11:10 AM to 11:15 AM (EDT) | PS66- Compartment-specific Transcriptomic Responses in Mouse Small Intestine Following Oral Exposure to Hexavalent Chromium

Grace Chappell, ToxStrategies, Inc., Katy, TX, (U.S.)

11:15 AM to 11:20 AM (EDT) | PS67- High-throughput Transcriptomic Analysis of Human Hepatocytes Exposed to Per- and Polyfluoroalkyl Substances for Hazard and Relative Potency Assessment.

Andrea Rowan-Carroll, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, (Canada)

11:20 AM to 11:25 AM (EDT) | PS68- High-Throughput Transcriptomics in Toxicology Testing: Evaluation of the “Omics Data Analysis Frameworks for Regulatory application” (R-ODAF)

Matthew Meier, Environmental Health Science and Research Bureau, Healthy Environments and Consumer Safety Branch, Health Canada, Ottawa, ON, (Canada)

In Vivo Mutagenesis

11:25 AM to 11:30 AM (EDT) | PS69- Temporal Analyses of Mutant Frequencies in Tubule Germ Cells of MutaMouse Animals Exposed to Benzo(a)pyrene or N-ethyl-N-nitrosourea Support the Use of the 28+28 Day Study Design for Assessing Germ Cell Mutagenicity

Gu Zhou, Health Science and Research Bureau, Health CanadaOttawa, ON, (Canada)

11:30 AM to 11:35 AM (EDT) | PS70- Mapping of DNA Damage in Prostate Cancer-related Genes in Vivo

Celeste Marin, Department of Chemistry and Biochemistry, Florida International University, 2Department of Human and Molecular Genetics, Florida International University, Miami, FL, (U.S.)

11:35 AM to 11:40 AM (EDT) | PS71- Duplex Sequencing™ Reveals Increases in Mutation Frequencies and C>T Transitions in the Bone Marrow of MutaMouse Males Exposed to Procarbazine

Annette Dodge,  Department of Biology, University of Ottawa, Ottawa, ON, (Canada)

11:40 AM to 11:45 AM (EDT) | PS72- Duplex Sequencing Reveals an Attenuated Mutation Frequency Increase in the Germ Cells of MutaMouse Males Exposed to N-ethyl-N-nitrosourea and Benzo[a]pyrene Relative to the TGR lacZ Assay

Danielle LeBlanc, Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, (Canada)

11:45 AM to 11:50 AM (EDT) | PS73- Mutagenic Response of Newly Developed gpt Delta Transgenic Rat Strain With Homozygous Transgene

Masaoki Masumura, National Institute of Health Sciences, Kanagawa, (Japan)

11:50 AM to 11:55 AM (EDT) | PS75- Assessment of Variability in Human DRC (DNA Repair Capacity) to Evaluate the Default Uncertainty Factor (UF) for Inter-individual Sensitivity to Environmental Mutagens

Madison Bell, University of OttawaOttawa, ON, (Canada)

11:55 AM to 12:00 PM (EDT) | PS76- A Revolution Within Genetic Toxicology: Towards Using Liver-on-Chip to Replace Conventional Genetic Toxicology Test Batteries

Thalita Boldrin Zanoni, Charles River Laboratories, Senneville, Quebec, Canada

12:00 PM to 12:05 PM (EDT) |  A Sequencing Method Using Single-strand Specific Nucleases Enhances The Accuracy Of Error-corrected Sequencing Technologies

Yuki Otsubo, Kao CorporationNihonbashi-Kayabacho, Chūō, Tokyo, Japan